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Unraveling the Epstein-Barr virus enigma: The puzzling role in multiple sclerosis development

Epstein-Barr virus (EBV) has a significant role in the development of multiple sclerosis (MS), with evidence linking EBV infection to increased MS risk and immune dysregulation. Understanding the mechanisms underlying this connection is crucial for advancing MS therapies and prevention strategies.

24 May 2023

Both vaccine strain and adjuvant selection are critical elements for improving the breadth of protective immunity against enterovirus D68

Researchers demonstrated the production of cross-clade neutralizing antibodies in response to EV-D68.

19 May 2023

New genome editing technology achieves efficient and precise large DNA insertions

GAO Caixia's group from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed a new genome editing technology that achieves efficient and precise targeted insertion of large DNA segments in plants.

24 Apr 2023

Novel self-amplifying RNA vaccine confers durable protection against COVID-19, reduces viral shedding in primate study

A self-amplifying replicon RNA vaccine against SARS-CoV-2 can elicit durable and protective immunity in pigtail macaques, even after neutralizing antibody responses have waned to undetectable levels.

23 Apr 2023

Nasal SARS-CoV-2 vaccine outperforms existing vaccines in preclinical trial

Researchers assess the role of the live-attenuated vaccine sCPD9 in inducing systemic and mucosal immunity against SARS-CoV-2 variants.

6 Apr 2023

Elucidating the function of BRCA2 gene offers insight into cancer development

A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA.

3 Apr 2023

Researchers create a visualization of the full-length human BRCA2 protein at single molecule level

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

31 Mar 2023

Candidate hepatitis C mRNA vaccine induces protective immunity in animal model

In a recent study published in the npj vaccines journal, researchers assessed the immune protection elicited by messenger ribonucleic acid (mRNA) vaccines delivering Hepatitis C virus (HCV) E1 and modified E2.

23 Mar 2023

SARS-CoV-2 infection enhances vaccine-induced immunological memory against spike protein

Researchers assess SARS-CoV-2 spike protein-specific immunological memory among unvaccinated and vaccinated convalescents.

22 Mar 2023

Novel mechanism by which “good” bacteria colonize the gut discovered

The microbes that inhabit the gut are critical for human health, and understanding the factors that encourage the growth of beneficial bacterial species — known as "good" bacteria — in the gut may enable medical interventions that promote gut and overall human health.

20 Mar 2023

A high-throughput CAMP assay for the evaluation of the vitamin D-dependent antimicrobial response

A recent developed a novel and high-throughput assay to evaluate cathelicidin antimicrobial peptide.

16 Mar 2023

TbID-based proteomic profiling in meiotic cells helps identify proximate proteins in A. thaliana

During meiosis, reshuffling of genetic information between homologous chromosomes through meiotic recombination creates variable gametes and hence genetic variation in offsprings.

13 Mar 2023

Study unveils a key factor involved in the DNA damage response and repair

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

Antibody levels from prime COVID-19 mRNA vaccine influences the efficacy of booster doses

Researchers evaluate the response of pre-existing immunity to booster doses of mRNA COVID-19 vaccines.

6 Mar 2023

Meta-analysis on COVID-19 vaccine effectiveness in association with antibody titers

Researchers performed a meta-analysis analyzing randomized controlled trials (RCTs) that evaluated the effectiveness of coronavirus disease 2019 (COVID-19) vaccines, and the dose-response association of humoral responses with vaccine effectiveness.

6 Mar 2023

SARS-CoV-2 BA.1 and BA.2 breakthrough infections likely protect against BA.4 infection

Omicron BTIs induce durable neutralizing immune responses by recalling cross-reactive and vaccine-induced memory B lymphocytes.

1 Mar 2023

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

28 Feb 2023

Is the advantage conferred by the heterologous regimen conserved after a booster dose of mRNA-based COVID-19 vaccine?

Researchers compared the efficacy of a third COVID-19 vaccine dose and that of homologous and heterologous regimens.

23 Feb 2023

Omicron BQ and XBB subvariants most resistant viruses to monoclonal antibodies

A recent study examines the neutralization of SARS-CoV-2 Omicron sub-variants by sera from boosted individuals and those with breakthrough infection.

13 Feb 2023

Vaccine efficacy and booster dose combinations among 18.9 million adults in the early phase of Omicron

A new study in the journal Clinical Infectious Diseases aimed to determine the relative vaccine effectiveness (rVE) in three different recipient cohorts, those who received the Ad26.COV2.S vaccine followed by Ad26.COV2.S booster, those who received the Ad26.COV2.S vaccine followed by an mRNA booster, and those who received two doses of an mRNA vaccine followed by an mRNA booster.

12 Feb 2023