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A hormone is a chemical released by one or more cells that affects cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. It is essentially a chemical messenger that transports a signal from one cell to another.
KU researchers find potential therapeutic target for triple-negative breast cancer

KU researchers find potential therapeutic target for triple-negative breast cancer

A team at the University of Kansas School of Medicine has identified a potential target for treating breast cancer, including a particularly deadly form of the disease. [More]
Neurocrine Biosciences' NBI-98854 drug gets breakthrough designation for tardive dyskinesia

Neurocrine Biosciences' NBI-98854 drug gets breakthrough designation for tardive dyskinesia

Neurocrine Biosciences, Inc. announced today that the U.S. Food and Drug Administration has granted Breakthrough Therapy Designation for its Vesicular Monoamine Transporter 2 inhibitor, NBI-98854, in tardive dyskinesia. [More]
Novel therapeutic approaches to improve thyroid cancer outcomes

Novel therapeutic approaches to improve thyroid cancer outcomes

Novel therapeutic approaches to improve outcomes in thyroid cancer, for example using targeted delivery of cytotoxic drugs to tumor cells, will be among the topics featured in oral and poster presentations delivered at the 84th Annual Meeting of the American Thyroid Association, October 29-November 2, 2014, in Coronado, California. [More]
New research findings on Graves' disease to be highlighted at ATA meeting

New research findings on Graves' disease to be highlighted at ATA meeting

A unique mouse model of Graves' disease, an autoimmune disorder that causes hyperthyroidism, and new research findings that may help improve the treatment of Graves' disease will be highlighted in oral and poster presentations at the 84th Annual Meeting of the American Thyroid Association, October 29-November 2, 2014, in Coronado, California. [More]
Ghrelin has potential to stimulate alcohol craving, study reveals

Ghrelin has potential to stimulate alcohol craving, study reveals

Ghrelin is a hormone released by the stomach and it stimulates appetite and food intake. Alcohol is commonly viewed as a psychoactive substance that primarily affects brain function, but it is also a highly caloric food. [More]
UMass Amherst epidemiologist investigates risk of early menopause

UMass Amherst epidemiologist investigates risk of early menopause

The estimated 10 percent of women in Western nations who enter menopause before age 45 have an elevated risk of cardiovascular disease, as well as lower fertility. Now epidemiologist Elizabeth Bertone-Johnson at the University of Massachusetts Amherst is conducting the first large study to investigate whether vitamin D deficiency, inflammatory factors, hormones and other factors are associated with risk of early menopause, funded by NIH. [More]
Generic aromatase inhibitors increase breast cancer treatment adherence by 50%

Generic aromatase inhibitors increase breast cancer treatment adherence by 50%

Although oral hormonal therapy is known to substantially reduce breast cancer recurrence in women with hormone receptor-positive tumors, about one-half of patients fail to take their medications as directed. A new study by Columbia University Medical Center researchers has found that the introduction of generic aromatase inhibitors (the most common type of hormone therapy), which are considerably less expensive than their brand name counterparts, increased treatment adherence by 50 percent. [More]
Understanding of genomic landscape of thyroid cancer

Understanding of genomic landscape of thyroid cancer

A new comprehensive analysis of thyroid cancer from The Cancer Genome Atlas Research Network has identified markers of aggressive tumors, which could allow for better targeting of appropriate treatments to individual patients. [More]
Rates of type 1 diabetes increase significantly among non-Hispanic white youth

Rates of type 1 diabetes increase significantly among non-Hispanic white youth

The rate of non-Hispanic white youth diagnosed with type 1 diabetes increased significantly from 2002 to 2009 in all but the youngest age group of children, according to a new study published today in the journal Diabetes. [More]
Study reveals subtypes, potential diagnostic and treatment clues for papillary thyroid carcinomas

Study reveals subtypes, potential diagnostic and treatment clues for papillary thyroid carcinomas

A comprehensive analysis of the genomes of nearly 500 papillary thyroid carcinomas (PTC) – the most common form of thyroid cancer – has provided new insights into the roles of frequently mutated cancer genes and other genomic alterations that drive disease development. [More]
Research shows FGF21 hormone acts directly on brain to regulate obesity

Research shows FGF21 hormone acts directly on brain to regulate obesity

A hormone seen as a popular target to develop weight-loss drugs works by directly targeting the brain and triggering previously unknown activity in the nervous system, UT Southwestern Medical Center obesity researchers have found. [More]
Fatty fish intake appears to increase antidepressant response rates

Fatty fish intake appears to increase antidepressant response rates

Up to half of patients who suffer from depression (Major Depressive Disorder, or MDD) do not respond to treatment with SSRIs (Selective Serotonin Reuptake Inhibitors). Now a group of Dutch researchers have carried out a study which shows that increasing fatty fish intake appears to increase the response rate in patients who do not respond to antidepressants. [More]
Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Janssen Research & Development, LLC today announced the submission of a supplemental New Drug Application (sNDA) for IMBRUVICA (ibrutinib) to the U.S. Food and Drug Administration by its strategic partner Pharmacyclics, Inc. [More]
Newborns of mothers who smoke during pregnancy have altered stress hormones, DNA

Newborns of mothers who smoke during pregnancy have altered stress hormones, DNA

Researchers from The Miriam Hospital have studied the effects of smoking during pregnancy and its impact on the stress response in newborn babies. Their research indicates that newborns of mothers who smoke cigarettes during pregnancy show lower levels of stress hormones, lowered stress response, and alterations in DNA for a gene that regulates passage of stress hormones from mother to fetus. [More]
Disruption of circadian rhythm linked to breast cancer, shows study

Disruption of circadian rhythm linked to breast cancer, shows study

The disruption of a person's circadian rhythm—their 24-hour biological clock—has been linked to an increased risk of breast cancer, according to new University of Georgia research. The culprit, in this study in particular, is artificial light. [More]
Females' natural resistance to bacterial pneumonia is linked to NOS3 enzyme

Females' natural resistance to bacterial pneumonia is linked to NOS3 enzyme

Researchers have linked increased resistance to bacterial pneumonia in female mice to an enzyme activated by the female sex hormone estrogen. [More]
Parental understanding regarding daily experiences may affect adolescent health, well-being

Parental understanding regarding daily experiences may affect adolescent health, well-being

Adolescents whose parents better understand their daily experiences have better psychological adjustment, suggests a study in the October issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society. [More]
New combination therapy shows promise in treating prostate cancer

New combination therapy shows promise in treating prostate cancer

Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness. [More]
LCSB scientists characterize new tumour suppressor gene

LCSB scientists characterize new tumour suppressor gene

Scientists at the Luxembourg Centre for Systems Biomedicine of the University of Luxembourg have published their findings that mutations in a gene known as "ARMC5" promote the growth of benign tumours in the adrenal glands and on the meninges: ARMC5 appears to belong to the group of so-called tumour suppressor genes. [More]
Bone mineral density not linked to musculoskeletal pain

Bone mineral density not linked to musculoskeletal pain

Bone mineral density does not contribute to musculoskeletal pain, researchers report in findings that shed light on the controversy over whether osteoporosis is a painless disease. [More]