Hybridization News and Research

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OGT launches new, easy-to-use Cytocell FISH probes website

Oxford Gene Technology, The Molecular Genetics Company, has launched a new version of its Cytocell fluorescence in situ hybridization probes website - designed to provide a wealth of information and advice, offer refined functionality, and be easy-to-use.

From Oxford Gene Technology 8 Mar 2018

Telomere length testing can alter treatment decisions for certain diseases

Research led by Johns Hopkins physicians and scientists shows that a test for measuring the length of DNA endcaps, called telomeres, which has a variability rate of 5 percent, can alter treatment decisions for patients with certain types of bone marrow failure.

27 Feb 2018

Novel gene expression analysis technique can accurately and quickly measure RNA

A University of Illinois and Mayo collaboration has demonstrated a novel gene expression analysis technique that can accurately measure levels of RNA quickly and directly from a cancerous tissue sample while preserving the spatial information across the tissue --something that conventional methods cannot do.

18 Jan 2018

Oncologists find new biomarker for breast cancer having poor prognosis

With the support of the FWF, an oncologist found a biomarker for breast cancer having a poor prognosis and developed two viable methods to detect it in tissue samples.

22 Nov 2017

Scientists develop novel technology that uses CRISPR to map genetic mutations

A team of scientists led by Virginia Commonwealth University physicist Jason Reed, Ph.D., have developed new nanomapping technology that could transform the way disease-causing genetic mutations are diagnosed and discovered.

21 Nov 2017

BWH researchers identify new rare genetic cause of peritoneal mesothelioma

Mesothelioma is a rare and aggressive tumor that, in many cases, results from exposure to asbestos. But over the last several decades, other causes of the disease have emerged, including treatment with high-intensity therapeutic radiation and, more recently, an inherited genetic mutation.

14 Sep 2017

Penn researchers find abnormally shortened telomeres in young DMD patients’ muscle stem cells

Researchers from the Perelman School of Medicine at the University of Pennsylvania have made a discovery about muscular dystrophy disorders that suggest new possibilities for treatment.

7 Sep 2017

Researchers decode complex finger millet genome in high quality for first time

Finger millet has two important properties: The grain is rich in important minerals and resistant towards drought and heat.

5 Sep 2017

Lunatic fringe gene plays role in regulating fate of neural stem cells

The discovery that the brain can generate new cells - about 700 new neurons each day - has triggered investigations to uncover how this process is regulated.

19 Jul 2017

Scientists use supercomputers to test new techniques for early cancer detection

An important factor in fighting cancer is the speed at which the disease can be identified, diagnosed and treated.

28 Jun 2017

OGT makes several advances in hybridization-based targeted sequencing

Oxford Gene Technology, The Molecular Genetics Company, has made several advances in hybridisation-based target enrichment protocols that now enable researchers to prepare samples for sequencing in just one day.

26 May 2017

Scientists identify key gene in 22q11.2 that contributes to genitourinary birth defects

The 22q11.2 region of human chromosome 22 is a hotspot for a variety of birth defects. Scientists learned about this region because it is deleted in about 1 in 4,000 births, causing the loss or duplication of up to 40 genes.

25 May 2017

Study identifies CD38 gene to be essential for postnatal glial cell development

Cells in the brain are categorized roughly into two; neurons and the others, namely, glial cells. It is essential for sound development of the brain that both neurons and glial cells develop in a normal and adequate manner not only at fetal but also postnatal stages.

7 Apr 2017

Researchers develop improved method for using graphene-based transistors to detect harmful genes

Researchers in India and Japan have developed an improved method for using graphene-based transistors to detect disease-causing genes.

1 Mar 2017

Using Spherical Nucleic Acids to Track and Treat Disease

Spherical nucleic acids are structures that are made by taking a nanoparticle template and using chemistry to arrange short strands of DNA or RNA on the surface of those particles. The spherical core of the nanoparticle creates a spherical arrangement of DNA or RNA, similar to tiny little balls of nucleic acids.

From Pittcon 1 Mar 2017

Johns Hopkins researchers find no evidence of CMV in aggressive brain cancer tissues

In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus (CMV) infection and conclude that a link between the two diseases, as claimed by earlier reports, likely does not exist.

1 Mar 2017

microDimensions launches new version of high precision whole slide alignment software

microDimensions launches a new version of its high precision whole slide alignment software Slidematch. With the new version users can align digital whole slide images from consecutive sections in brightfield and fluorescence mode, e.g. for the evaluation of the HER2 status of cancer patients.

From microDimensions - Bramlage Scientific GmbH 21 Feb 2017

Research unravels molecular mechanisms of antisense oligonucleotides

Stanley T. Crooke, MD, PhD, CEO of Ionis Pharmaceuticals and recipient of the 2016 Lifetime Achievement Award from the Oligonucleotide Therapeutic Society presents a detailed look at the mechanisms that underlie antisense drug activity in the article entitled "Molecular Mechanisms of Antisense Oligonucleotides," published in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

2 Feb 2017

USP researchers develop new platform to detect 416 viruses from tropical regions

Researchers from the University of São Paulo at Ribeirão Preto in Brazil have developed a platform that analyzes clinical samples from patients to diagnose infection by 416 viruses found in the world's tropical regions.

1 Dec 2016