Hypoplastic Left Heart Syndrome News and Research

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Hypoplastic left heart syndrome (HLHS) is a problem with the heart’s structure that is present at birth (congenital). It is a group of related defects that, together, mean that the left side of the heart is underdeveloped. Normally, oxygen-poor blood is pumped through the right side of the heart to the lungs, where it gains oxygen and returns to the left side of the heart. The oxygen-rich blood is then pumped from the left side of the heart to the rest of the body. At birth, all babies also have two connections, or shunts, between the two sides of the heart; however, within a few days of birth these connections close.

NHLBI selects U-M Congenital Heart Center for clinical research

The University of Michigan Congenital Heart Center has been selected as a new Pediatric Heart Network core site for clinical research. Created and funded by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health, the Pediatric Heart Network is a cooperative network of pediatric cardiovascular clinical research centers that conducts studies in children with congenital or acquired heart disease.

20 Aug 2011

Doctors should consider catheterization for diagnosing children with heart defects: AHA

Doctors should consider using catheterization as a treatment tool in addition to its established role in diagnosing children with heart defects, according to a new American Heart Association scientific statement.

3 May 2011

Study finds association between ERBB4 gene, LVOT malformations

A gene known to be important in cardiac development has been newly associated with congenital heart malformations that result in obstruction of the left ventricular outflow tract. These are the findings from a study conducted by Nationwide Children's Hospital and appearing in the journal Birth Defects Research Part A.

30 Apr 2011

Non-Hispanic black infants born with heart defects more likely to die within five years

Non-Hispanic black infants born with heart defects are more likely to die within the first five years of life than their non-Hispanic white and Hispanic peers. For certain types of congenital heart abnormalities, Hispanic children as well as non-Hispanic black children fare worse than non-Hispanic white children.

18 Apr 2011

Pediatric physicians present 12 research abstracts, posters at Cardiology 2011

Pediatric cardiology researchers and clinicians gather this week in Scottsdale, Ariz. for Cardiology 2011, the 15th Annual Update on Pediatric and Congenital Cardiovascular Disease, sponsored by The Children's Hospital of Philadelphia. Original research from more than 30 cardiac programs in the U.S. and abroad is being presented throughout the meeting.

7 Feb 2011

U.S mortality rate from congenital heart defects drops 24%: Report

The U.S. death rate from congenital heart defects dropped 24 percent from 1999 to 2006 among children and adults, according to research reported in Circulation: Journal of the American Heart Association.

23 Nov 2010

Two-thirds of fetuses with HLHS have strong chance of survival

When prenatal diagnosis detects the severe heart defect hypoplastic left heart syndrome (HLHS) in a fetus, a comprehensive prenatal evaluation is important to provide parents an accurate prognosis. In HLHS, one of the heart's pumping chambers is severely underdeveloped. However, say researchers, in two-thirds of cases, reconstructive surgery affords the infant an excellent chance of early survival.

27 Oct 2010

New surgical procedure improves survival in infants with severely underdeveloped hearts

Pediatric researchers report that a recently introduced surgical procedure offers infants with severely underdeveloped hearts a better chance at surviving during their first year of life in comparison to the standard surgery.

28 May 2010

Usage of shunts to direct blood flow to lungs can help kids born with hypoplastic left heart syndrome

A trial on shunts used to direct blood flow to the lungs, led by researchers at the University of Michigan's C.S. Mott Children's Hospital, will lead to better outcomes for kids worldwide born with hypoplastic left heart syndrome, the most common severe heart birth defect.

27 May 2010

Largest clinical trial to compare surgical treatments for congenital heart disease

27 May 2010

Infants born with complex congenital heart disease also at risk for life-threatening gastrointestinal diseases

Infants born with complex congenital heart disease are not only at risk for serious heart-related complications, but also for developing a deadly bowel disease, regardless of the type of surgical intervention they receive for their heart. These are the findings from a study by Nationwide Children's Hospital, and appearing in Pediatric Critical Care Medicine published online May 6 ahead of print.

27 May 2010

Researchers discover genetic variant that raises risk of CHD

Although congenital heart disease represents the most common major birth defect, scientists have not previously identified the common variation in the genes that give rise to it. Now genetics and cardiology researchers, two of them brothers, have discovered a genetic variant on chromosome 5 that strongly raises the risk of congenital heart disease.

27 May 2010

New study may lead to better outcomes for kids born with hypoplastic left heart syndrome

27 May 2010

Cardiology 2010 conference focuses on current treatments for children with heart disease

An international group of over 900 medical experts gathers today to discuss the most current treatments for children with heart disease. Affecting about 8 in every 1,000 children, congenital (present at birth) heart disease is the most common birth defect. In its severe forms, it is also the leading cause of death from birth defects in infants.

10 Feb 2010

60% of pregnant women never tested for CHD

Three out of five women who have given birth to a child with a congenital heart defect (CHD) -- the number-one birth defect and leading killer of infants and newborns -- were never tested for the defect during pregnancy. This is according to a survey just released by Little Hearts, Inc., a national organization that provides support, education, resources, networking and hope to families affected by congenital heart defects.

9 Feb 2010

NHLBI grant for identifying genetic and epigenetic causes of human congenital heart disease

Researchers at Children's Hospital Boston and Brigham and Women's Hospital have received funding from the National Heart, Lung, and Blood Institute (NHLBI) to support their search for undiscovered gene defects that cause congenital heart disease. The $4.19 million, 6-year grant is part of the Pediatric Cardiac Genomics Consortium (PCGC), which seeks to identify genetic and epigenetic causes of human congenital heart disease, and relate genetic variants present in the congenital heart disease patient population to clinical outcomes.

23 Dec 2009

Landmark study provides new insight into congenital heart defects

Researchers from the UC San Diego, School of Medicine and colleagues have identified a new gene, ETS-1, that is linked to human congenital heart defects. The landmark study, recently published online in the journal of Human Molecular Genetics, provides important insights into some of the most prevalent forms of congenital heart defects in humans, including ventricular septal defects and potentially hypoplastic left heart syndrome, a uniformly fatal heart abnormality.

18 Dec 2009

New hybrid catheterization table for Toshiba America Medical Systems' five-axis Infinix-i cardiovascular X-ray line

Toshiba America Medical Systems, Inc. has introduced the CAT-880B, a new hybrid catheterization table, for its five-axis InfinixTM-i cardiovascular X-ray line.

2 Dec 2009

Sildenafil drug improves cardiac performance in young adults with congenital heart disease

Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

19 Nov 2009

Sildenafil improves heart function in youngsters with single ventricle congenital heart disease

Heart function significantly improved in children and young adults with single ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia.

18 Nov 2009

Hypoplastic Left Heart Syndrome News and Research

Further Reading

NHLBI selects U-M Congenital Heart Center for clinical research

Doctors should consider catheterization for diagnosing children with heart defects: AHA

Study finds association between ERBB4 gene, LVOT malformations

Non-Hispanic black infants born with heart defects more likely to die within five years

Pediatric physicians present 12 research abstracts, posters at Cardiology 2011

U.S mortality rate from congenital heart defects drops 24%: Report

Two-thirds of fetuses with HLHS have strong chance of survival

New surgical procedure improves survival in infants with severely underdeveloped hearts

Usage of shunts to direct blood flow to lungs can help kids born with hypoplastic left heart syndrome

Largest clinical trial to compare surgical treatments for congenital heart disease

Infants born with complex congenital heart disease also at risk for life-threatening gastrointestinal diseases

Researchers discover genetic variant that raises risk of CHD

New study may lead to better outcomes for kids born with hypoplastic left heart syndrome

Cardiology 2010 conference focuses on current treatments for children with heart disease

60% of pregnant women never tested for CHD

NHLBI grant for identifying genetic and epigenetic causes of human congenital heart disease

Landmark study provides new insight into congenital heart defects

New hybrid catheterization table for Toshiba America Medical Systems' five-axis Infinix-i cardiovascular X-ray line

Sildenafil drug improves cardiac performance in young adults with congenital heart disease

Sildenafil improves heart function in youngsters with single ventricle congenital heart disease

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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