Immunophenotyping News and Research

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Immunophenotyping is a test used to identify cells on the basis of the types of markers or antigens present on the cell’s surface, nucleus, or cytoplasm. This technique helps identify the lineage of cells using antibodies that detect markers or antigens on the cells, hence the “immuno-” prefix.

T cell immunity induced after mild COVID could contribute to protection against re-infection

An interesting new study finds that in both adults and children, a mild infection with the SARS-CoV-2 elicits an antigen-specific memory T-cell response.

20 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

A team of scientists in Ireland recently identified certain immune markers that can predict the progression of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to severe coronavirus disease 2019 (COVID-19). Early detection of these predictive markers can facilitate therapeutic decision-making prior to peak severity.

7 Sep 2021

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Recently, a new study published on the pre-print server bioRxiv* examined the effect that maternal asymptomatic COVID-19 had on decidual and peripheral immune cells during the later stage of pregnancy.

30 Aug 2021

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

A study analyzes the immune responses of medical personnel, as well as immunocompromised DP and immunosuppressed KTR patients.

27 Jul 2021

Neuropathology of COVID-19 patients caused by infection of brain pericytes

Recently, researchers from the UK and Sweden used highly sensitive multiplexed immunohistochemistry to study the brain tissue of COVID-19 patients and controls to analyze ACE2 expression in brain pericytes of patients with neurological symptoms. They also used spatial immunophenotyping to assess inflammation in brain tissue of COVID-19 patients.

31 May 2021

Beckman Coulter Life Sciences launches next-generation CytoFLEX SRT benchtop cell sorter

Leading the way for more than 85 years, Beckman Coulter Life Sciences proudly announces the launch of its highly anticipated CytoFLEX SRT Benchtop Sorter-- the CytoFLEX that sorts, and features expanded laser and color options for use in labs of all sizes.

From Beckman Coulter Life Sciences 4 Mar 2021

Insight into role of aging in response to SARS-CoV-2 infection

Researchers at the University of California, Irvine set out to determine the differences between young people and older adults regarding their host responses against SARS-CoV-2. The team revealed that independent of disease severity, COVID-19 was linked to a significant shift in plasma inflammatory factors. The research is posted to the pre-print server medRxiv*.

3 Feb 2021

Granulocyte changes could help predict patient outcomes in COVID-19

Researchers in Sweden have provided a comprehensive characterization of circulating granulocytes in people infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

1 Feb 2021

Challenges in High Complexity Flow Cytometry

In this interview, Dra. Mª José Marco from the Department of Hematology at Hopsital Dr. Peset talks to News-Medical Life Sciences about high complexity flow cytometry and the challenges they often face.

From Beckman Coulter Life Sciences - Flow Cytometry 24 Sep 2020

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

In a recent bioRxiv preprint paper, researchers from the Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, and Department of Global Health, University of Washington, Seattle, WA, discuss their study in mice that undergo detailed immunophenotyping before getting infected with SARS-CoV.

22 Sep 2020

Rare COVID-19 related illness in children causes profound immune changes

Researchers have uncovered how the immune system is altered in a rare COVID-19 related illness in children referred to as paediatric inflammatory multisystem syndrome (PIMS-TS).

18 Aug 2020

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

20 Jul 2020

Immunophenotyping News and Research

Further Reading

T cell immunity induced after mild COVID could contribute to protection against re-infection

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

Severe COVID-19 is associated with expansion of immature myeloid cells and inflammation

The impact of mild SARS-CoV-2 infection on maternal-fetal immunity

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

Neuropathology of COVID-19 patients caused by infection of brain pericytes

Beckman Coulter Life Sciences launches next-generation CytoFLEX SRT benchtop cell sorter

Insight into role of aging in response to SARS-CoV-2 infection

Granulocyte changes could help predict patient outcomes in COVID-19

Challenges in High Complexity Flow Cytometry

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

Rare COVID-19 related illness in children causes profound immune changes

Josep Carreras Institute's spin-off aims to develop new immuno-oncological therapeutic tools

Combination of radiation and immunotherapy shows promise for advanced head and neck cancers

Indivumed and Biognosys partnership aims to enhance proteomics insights

Study may help develop ibrutinib-based combination therapies for blood cancer

Beckman Coulter Life Sciences publishes ClearLLab Control Cells white paper

HORIBA Medical announces first multi-site installation of HELO modular automated hematology platform

Researchers develop a standardized method for predicting transplant rejection

Beckman Coulter launches new ClearLLab 10C System for clinical flow cytometry lab

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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