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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.
One million serious medical complications could be avoided with improvements in blood glucose levels in diabetics

One million serious medical complications could be avoided with improvements in blood glucose levels in diabetics

Sanofi, Diabetes UK and JDRF today announce the publication of IMPACT 2 in the journal Diabetic Medicine. This new study shows that, if sustained, even modest improvement in blood glucose levels can provide significantly improved outcomes for the 3.5 million people diagnosed with diabetes in the UK. [More]
Potential treatment target identified for fatty liver disease

Potential treatment target identified for fatty liver disease

Two proteins, p38 gamma and p38 delta, control the accumulation of fat in the liver, a process linked to the development of insulin resistance and diabetes, which are common outcomes of obesity. These findings are presented in an article published by researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). [More]
Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

Maternal diet during pregnancy and lactation leads to epigenetic changes in offspring

As the study shows, a high-fat diet during pregnancy and lactation leads to epigenetic changes in the offspring. These changes affect metabolic pathways regulated by the gut hormone GIP, whereby the adult offspring are more susceptible to obesity and insulin resistance, the precursor to type 2 diabetes. Similar mechanisms cannot be ruled out in humans, according to Pfeiffer. [More]
Irregular sleep schedules linked to adverse metabolic health in midlife women

Irregular sleep schedules linked to adverse metabolic health in midlife women

A new study suggests that frequent shifts in sleep timing may be related to adverse metabolic health among non-shift working, midlife women. [More]
Weight loss programs that provide healthy fats have similar impacts on pound-shedding

Weight loss programs that provide healthy fats have similar impacts on pound-shedding

A University of California, San Diego School of Medicine study finds that weight loss programs that provide healthy fats, such as olive oil in the Mediterranean diet, or a low-fat, high-carbohydrate diet have similar impacts on pound-shedding. [More]
Second-hand smoke exposure linked to larger waist, poorer cognition in children

Second-hand smoke exposure linked to larger waist, poorer cognition in children

Exposure to second-hand smoke is associated with a larger waist and poorer cognition in children, researchers say. [More]
Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

Study finds possibility of targeting Orai3 as novel treatment for obesity-related inflammation

A new study by a team of Rosalind Franklin University researchers headed by Carl White, PhD, assistant professor of physiology and biophysics, has discovered that the degree of chronic inflammation caused by obesity is highly dependent on levels of the signaling molecule, hydrogen sulfide, which alters the activity of a calcium channel, Orai3. [More]
Lilly receives FDA approval for Humulin R U-500 KwikPen

Lilly receives FDA approval for Humulin R U-500 KwikPen

The U.S. Food and Drug Administration has approved Eli Lilly and Company's Humulin R U-500 KwikPen(insulin human injection) 500 units/mL, a pre-filled device containing Humulin R U-500, a highly concentrated formulation of insulin. [More]
Short bursts of intensive exercise could be more effective in preventing Type 2 diabetes

Short bursts of intensive exercise could be more effective in preventing Type 2 diabetes

Short bursts of intensive exercise provide a more "time-efficient" and realistic way of preventing, delaying and managing Type 2 diabetes and also losing weight, a study has found. [More]
Scientists identify unusual regulator of body weight, metabolic syndrome

Scientists identify unusual regulator of body weight, metabolic syndrome

Scientists at the Gladstone Institutes have discovered an unusual regulator of body weight and the metabolic syndrome: a molecular mechanism more commonly associated with brain cells. Lowering levels of P75 neurotrophin receptor (NTR)--a receptor involved in neuron growth and survival--protected mice fed a high-fat diet from developing obesity, diabetes, and fatty liver disease. [More]
Cancer concerns over chromium diet pills

Cancer concerns over chromium diet pills

Concerns have been raised over the long-term use of nutritional supplements containing chromium, after an Australian research team found the supplement is partially converted into a carcinogenic form when it enters cells. [More]
UCA researchers create new animal models to study link between diabetes and Alzheimer's disease

UCA researchers create new animal models to study link between diabetes and Alzheimer's disease

In recent time, many epidemiological studies have proved very close links existing between diabetes and Alzheimer´s disease. In fact, it has been stated that diabetes is a significant risk factor for suffering from Alzheimer and vascular dementia, the two main causes of dementia. [More]
Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

Researchers discover methods for reducing age-related stem cell dysfunction, metabolic disease in aged mice

Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease. That includes diabetes, which affects 12.2 million Americans age 60 and older, according to the National Council on Aging. [More]
Regulus begins RG-125(AZD4076) Phase I study for treatment of NASH in patients with type 2 diabetes/pre-diabetes

Regulus begins RG-125(AZD4076) Phase I study for treatment of NASH in patients with type 2 diabetes/pre-diabetes

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today that dosing has begun in a first-in-human Phase I clinical study of RG-125(AZD4076), by its collaboration partner AstraZeneca. [More]
Oxford research programmes to explore link between metabolism, inflammation in metabolic diseases

Oxford research programmes to explore link between metabolism, inflammation in metabolic diseases

Two innovative Oxford research programmes will explore the relationship between metabolism and inflammation in metabolic diseases. Obesity, insulin resistance, type 2 diabetes (T2D) and associated cardiovascular disease (CVD) -- all metabolic diseases -- are an epidemic global health problem. [More]
Bile acid may help treat fatty liver disease and obesity

Bile acid may help treat fatty liver disease and obesity

A bile acid that can turn off a receptor in the gut has prevented and reversed fatty liver disease in mice, according to an international team of researchers. The compound may help treat certain metabolic disorders, such as Type 2 diabetes and obesity, as well. [More]
Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

Liver protein aids in accelerating growth of insulin-producing pancreatic 'beta' cells

More than a quarter of the 30 million people with diabetes in the United States depend on daily injections of insulin to maintain their blood glucose levels in a healthy range. Scientists are investigating many techniques to help treat or potentially even cure many of these patients by increasing the body's own insulin-producing pancreatic "beta" cells. [More]
Maternal smoking affects long-term health of male offspring

Maternal smoking affects long-term health of male offspring

Mothers who smoke are putting more than their own health at risk, suggests a study published today in BJOG: an International Journal of Obstetrics and Gynaecology. Young men whose mothers smoked during pregnancy had lower aerobic fitness compared to those whose mothers did not. [More]
TSRI scientists use new drug discovery technique to identify anti-diabetes compound

TSRI scientists use new drug discovery technique to identify anti-diabetes compound

Scientists from The Scripps Research Institute have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action. [More]
Testosterone treatment can benefit men with Type 2 diabetes

Testosterone treatment can benefit men with Type 2 diabetes

Men with Type 2 diabetes who have low testosterone levels can benefit significantly from testosterone treatment. [More]
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