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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.
Drug for reduction of abdominal fat in HIV patients may also reduce fatty liver disease

Drug for reduction of abdominal fat in HIV patients may also reduce fatty liver disease

The only drug to receive FDA approval for reduction of the abdominal fat deposits that develop in some patients receiving antiviral therapy for HIV infection may also reduce the incidence of fatty liver disease in such patients. [More]
Single injection of protein FGF1 enough to restore blood sugar levels

Single injection of protein FGF1 enough to restore blood sugar levels

In mice with diet-induced diabetes—the equivalent of type 2 diabetes in humans—a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for more than two days. [More]
Physical fitness may buffer some of adverse health effects of too much sitting

Physical fitness may buffer some of adverse health effects of too much sitting

Physical fitness may buffer some of the adverse health effects of too much sitting, according to a new study by researchers from the American Cancer Society, The Cooper Institute, and the University of Texas. [More]
Promising new drug for metabolic syndrome

Promising new drug for metabolic syndrome

University of Utah researchers have discovered that an enzyme involved in intracellular signaling plays a crucial role in developing metabolic syndrome, a finding that has a U of U spinoff company developing a drug to potentially treat the condition. [More]
Study reveals mechanism underlying abnormal fat accumulation in HIV patients

Study reveals mechanism underlying abnormal fat accumulation in HIV patients

Building upon their earlier research on the biology of fat metabolism, Joslin scientists discovered that microRNAs -small RNA molecules that play important roles in regulation in many types of tissue - play a major role in the distribution and determination of fat cells and whole body metabolism. [More]
A*STAR scientists pioneered a molecular connection between obesity and diabetes

A*STAR scientists pioneered a molecular connection between obesity and diabetes

Scientists from the Institute of Molecular and Cell Biology, a research institute under the Agency for Science, Technology and Research, have discovered that obese individuals lack a protein that is essential for regulating blood glucose levels, causing them to face higher risks of developing diabetes. [More]
Soy protein supplements do not reduce testosterone levels in men with Type 2 diabetes

Soy protein supplements do not reduce testosterone levels in men with Type 2 diabetes

Soy protein supplements, which contain natural estrogens, do not reduce testosterone levels in men with Type 2 diabetes who already have borderline-low testosterone, according to a new study. [More]
Study explores new ways to improve medications to treat type 2 diabetes

Study explores new ways to improve medications to treat type 2 diabetes

A better understanding of how the transcription factor Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma) works is critical to find new ways to improve medications to treat type 2 diabetes. [More]
Researchers shown how free radicals contribute to fatty liver disease

Researchers shown how free radicals contribute to fatty liver disease

An international team of scientists led by Monash University researchers has shown how free radicals contribute to type 2 diabetes, obesity and fatty liver disease. [More]
African American women respond differently to anti-inflammatory effect of aspirin than white women

African American women respond differently to anti-inflammatory effect of aspirin than white women

African American women respond differently to the anti-inflammatory effect of aspirin than do white American women, new research finds. [More]
Continuation of metformin after cirrhosis diagnosis improves survival rates in diabetes patients

Continuation of metformin after cirrhosis diagnosis improves survival rates in diabetes patients

Researchers at Mayo Clinic released a new study reversing current thought on the treatment of cirrhotic patients with type 2 diabetes. [More]
Study of SLC13 transporters unlocks their therapeutic potential

Study of SLC13 transporters unlocks their therapeutic potential

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology. [More]

Mayo Clinic study: Reversing current thought on treatment of cirrhotic patients with type 2 diabetes

Researchers at Mayo Clinic released a new study reversing current thought on the treatment of cirrhotic patients with type 2 diabetes. The study found that the continuation of metformin after a cirrhosis diagnosis improved survival rates among diabetes patients. [More]
New studies shed light on the mechanism of childhood obesity

New studies shed light on the mechanism of childhood obesity

With the increase in childhood obesity and the associated increase in type 2 diabetes among children and adolescents, there is growing interest in how children's bodies process the foods they eat and how obesity and diabetes begin to develop at early ages. [More]
Researchers demonstrate potential of retinoic acid in preventing type 2 diabetes complications

Researchers demonstrate potential of retinoic acid in preventing type 2 diabetes complications

At a time when obesity, type 2 diabetes, and their complications are a veritable epidemic worldwide, researchers at the University of Montreal and CHUM Research Centre (CRCHUM) recently demonstrated the potential of retinoic acid (RA), a derivative of Vitamin A, in treating obesity and type 2 diabetes and preventing their cardiovascular complications. [More]
Fasting converts bad cholesterol in fat cells to energy, combating diabetes risk factors

Fasting converts bad cholesterol in fat cells to energy, combating diabetes risk factors

For prediabetics, many interventions focus on lifestyle changes and weight loss, but new research on periodic fasting has identified a biological process in the body that converts bad cholesterol in fat cells to energy, thus combating diabetes risk factors. [More]
Weight loss most important factor for improving cardiovascular health in obese OSA patients

Weight loss most important factor for improving cardiovascular health in obese OSA patients

Obesity and obstructive sleep apnea (OSA) tend to co-exist and are associated with a variety of cardiovascular risk factors, including inflammation, insulin resistance, abnormal cholesterol, and high blood pressure. While effective therapies are available for OSA, researchers are still unclear about what interventions are most effective in reducing the burden of risk factors for cardiovascular disease associated with OSA in obese patients. [More]
FDA grants orphan drug designation to EffRx Pharmaceuticals' EX404 for treatment of PCOS

FDA grants orphan drug designation to EffRx Pharmaceuticals' EX404 for treatment of PCOS

EffRx Pharmaceuticals SA, a specialty pharmaceutical company, today announced that the U.S. Food and Drug Administration has granted orphan drug designation to its proprietary metformin-based product candidate, EX404, for the treatment of pediatric polycystic ovary syndrome (PCOS). [More]
Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

Endocrine Society announces winners of Early Investigators Awards and FLARE Internship Awards

The Endocrine Society is pleased to announce the recipients of the 2014 Early Investigators Awards and the Future Leaders Advancing Research in Endocrinology Internship Awards. [More]
Lack of O2 in fat cells triggers inflammation and insulin resistance in obesity

Lack of O2 in fat cells triggers inflammation and insulin resistance in obesity

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes. [More]