Interleukin 6 News and Research

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Interleukin-6 (IL-6) is a protein that in humans is encoded by the "IL6" gene. IL-6 is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation.

New study: Loneliness can harm overall health

New research links loneliness to a number of dysfunctional immune responses, suggesting that being lonely has the potential to harm overall health.

20 Jan 2013

Miscarriage and molecular signals: an interview with Prof Brosens and Prof Quenby

Miscarriage is defined as the spontaneous loss of pregnancy before the baby reaches viability. Besides the physical trauma, miscarriage causes considerable anxiety, stress, and depression.

17 Jan 2013

Cerebrospinal fluid IL-6 increased in schizophrenia

Cerebrospinal fluid levels of interleukin-6 are significantly increased in patients with schizophrenia and major depressive disorder, Japanese study results show.

9 Jan 2013

Fertility window research uncovers miscarriage mechanism

Research in animals has shed light on how recurrent miscarriage is related to a dysregulation of the monthly “fertility window.”

8 Jan 2013

Arterial elasticity link to lung function

People with reduced arterial elasticity may have impaired lung function, and vice versa, say US researchers.

8 Jan 2013

Shoulder complaint linked to diabetes diagnosis

Study findings confirm suspicions that patients with diabetes have an increased risk for adhesive capsulitis of the shoulder.

7 Jan 2013

Report shows how P. gingivalis manipulates body's immune system to disable normal processes

A new research report published in the Journal of Leukocyte Biology shows how the bacteria known for causing gum disease--Porphyromonas gingivalis--manipulates the body's immune system to disable normal processes that would otherwise destroy it. Specifically, the report shows that this pathogen prompts the production of the anti-inflammatory molecule Interleukin-10 (IL-10).

4 Jan 2013

Scientists discover process by which mda-9/syntenin contributes to melanoma metastasis

After recently announcing success in eliminating melanoma metastasis in laboratory experiments, scientists at Virginia Commonwealth University Massey Cancer Center have made another important discovery in understanding the process by which the gene mda-9/syntenin contributes to metastasis in melanoma (the spread of skin cancer) and possibly a variety of other cancers.

4 Jan 2013

T. gondii infection linked to bipolar disorder risk

Results from a French study support an association between Toxoplasma gondii infection and bipolar disorder.

2 Jan 2013

Insights into tissue-based T cells

US researchers have, for the first time, characterized T cells located in human tissues, rather than in the blood.

31 Dec 2012

Uncharacterized TLR plays key role in Toxoplasma gondii response

A previously uncharacterized toll-like receptor appears to play a crucial role in the innate immune response to Toxoplasma gondii infection and may promote host resistance, potentially leading to anti-parasite vaccines, say US researchers.

28 Dec 2012

Shift-and-persist strategies, supportive role models may reduce physiological burden of poor teens

Low-income teenagers who have supportive role models and engage in adaptive strategies have lower levels of a marker for cardiovascular risk than low-income teens without such resources, according to a new study.

21 Dec 2012

Food and Function journal publishes Hass Avocado Board study

The Hass Avocado Board (HAB) is supporting research to improve understanding of the unique, positive benefits of consuming fresh avocados to human health and nutrition.

19 Dec 2012

Cytokine rise signals RCC progression

Progression of renal cell carcinoma is frequently preceded by a rise in levels of proangiogenic cytokines, Italian researchers have found.

17 Dec 2012

FoxP3 gene expression identifies ALS disease progression in 80% of patients

The debilitating symptoms of amyotrophic lateral sclerosis, or ALS, appear to be increased by a lack of inflammation-reducing T cells, report scientists from the Methodist Neurological Institute in an upcoming print issue of The EMBO Molecular Medicine Journal.

10 Dec 2012

Combining 5-fluorouracil and IL-1 beta inhibitor can improve effectiveness of chemotherapy

These results reveal how the immune system can then limit the effectiveness of some cancer chemotherapies. The researchers now intend to block the molecules responsible for negative immune system activation to increase the efficiency of chemotherapy. A clinical trial to test this hypothesis should begin very soon.

5 Dec 2012

Inflammatory marker targeted in ear infection

Systemic injection of an antibody against granulocyte/macrophage colony-stimulating factor inhibits middle-ear inflammation induced by lipopolysaccharide in mice, study findings show.

3 Dec 2012

Study examines role of inflammation in chronic fatigue syndrome

A new study published in the current issue of Psychotherapy and Psychosomatics has examined the role of inflammation in chronic fatigue syndrome, a disorder that affects many people and does not seem to have an explanation that is likely to yield satisfactory treatment.

1 Dec 2012

Periodontal disease identified using salivary biomarkers

Markers of inflammation found in saliva could be used to identify periodontal disease in large epidemiologic surveys, avoiding the need for cumbersome and expensive tests, suggest researchers.

29 Nov 2012

CEL-SCI's Multikine cancer drug receives key Japanese patent

CEL-SCI Corporation today announced that the Japanese patent office has issued a key patent covering CEL-SCI's investigational cancer drug, Multikine (Leukocyte Interleukin, Injection).

29 Nov 2012