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Researchers make breakthrough in gene therapy for sickle cell disease

Researchers at the National Institutes of Health have developed a new and improved viral vector--a virus-based vehicle that delivers therapeutic genes--for use in gene therapy for sickle cell disease.

2 Oct 2019

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University's Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer.

2 Oct 2019

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center.

18 Sep 2019

SATI gene editing could replace CRISPR

Scientists have developed a new gene editing tool called SATI that is safer than CRISPR.

2 Sep 2019

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

The ability to edit genes in living organisms offers the opportunity to treat a plethora of inherited diseases. However, many types of gene-editing tools are unable to target critical areas of DNA, and creating such a technology has been difficult as living tissue contains diverse types of cells.

26 Aug 2019

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018

New breakthrough may speed up research and drug trials to tackle motor neurone disease

Scientists from the University of Sheffield have successfully created zebrafish that carry the complex genetic change known to cause the most common genetic form of motor neurone disease (MND).

27 Nov 2018

Researchers identify single gene that regulates highly diverse ladybird color patterns

Many ladybirds have attractive color patterns consisting of black and red. This prominent color pattern is thought to function as a warning that indicates to predators that they are very bitter and unpalatable.

27 Sep 2018

Researchers predict how splicing errors impact disease risk

No one knows how many times in a day, or even an hour, the trillions of cells in our body need to make proteins.

31 Aug 2018

Use of HIV RNA expression inhibitors restores immune function in HIV patients on cART

Immune activation and inflammation persist in the majority of treated HIV-infected individuals and is associated with excess risk of mortality and morbidity.

28 Aug 2018

Gene regulator associated with protein pileup in exfoliation glaucoma

In exfoliation glaucoma, a protein dandruff clogs the outflow pathway for the fluid in our eyes.

19 Jul 2018

Myriad and Clovis ink deal on FDA-approved BRACAnalysis CDx test to identify patients with germline BRCA mutations for rucaparib treatment

Myriad Genetics, Inc. and Clovis Oncology, Inc. have announced a companion diagnostic collaboration to support a post-marketing regulatory commitment related to Clovis’ PARP inhibitor, Rubraca. Financial terms of the deal were not disclosed.

3 May 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

New MIP system for therapeutic gene delivery can enhance transgene expression using AAV vector

Advanced engineering of a mini-intronic plasmid (MIP) system designed to carry a therapeutic gene can significantly enhance the expression of the transgene delivered using an adeno-associated viral (AAV) vector.

28 Jan 2017

HC-based NGS helps detect genomic alterations not identified in routine lung cancer screening

The use of hybrid capture-based (HC-based) next-generation sequencing (NGS) to identify targetable oncogenic drivers in patients with lung adenocarcinoma results in the detection of genomic alterations (GAs) not identified in routine screening, and impacts treatment decisions and clinical outcomes.

17 Nov 2016

Intron News and Research

Researchers make breakthrough in gene therapy for sickle cell disease

Discovery of neoantigens could widen the possibilities for universal cancer vaccine

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

SATI gene editing could replace CRISPR

Salk researchers develop new gene-editing tool to target broad range of mutations, cell types

Uncovering the Structure of HIV Integrase to Inform Drug Discovery

Research may pave way for development of potent weapons against cancer

New breakthrough may speed up research and drug trials to tackle motor neurone disease

Researchers identify single gene that regulates highly diverse ladybird color patterns

Researchers predict how splicing errors impact disease risk

Use of HIV RNA expression inhibitors restores immune function in HIV patients on cART

Gene regulator associated with protein pileup in exfoliation glaucoma

Myriad and Clovis ink deal on FDA-approved BRACAnalysis CDx test to identify patients with germline BRCA mutations for rucaparib treatment

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

New MIP system for therapeutic gene delivery can enhance transgene expression using AAV vector

HC-based NGS helps detect genomic alterations not identified in routine lung cancer screening

Epigenetic changes from stress exposure can be passed from traumatized parent to offspring

Cloned Zika virus could be used for development of attenuated vaccine

Rice University researchers synthesize new anti-cancer agent

Scientists discover unexpected functions of snoRNAs that explains cause of some diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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