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Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

Intrigued by the properties of ion channel proteins commonly observed in cells, Tokyo Tech researchers have developed the first synthetic mechanosensitive potassium channel using a newly developed aromatic fluorinated amphiphilic cyclophane.

15 Jul 2022

New wireless technology remotely activates specific brain circuits in under one second

A research team led by Rice University neuroengineers has created wireless technology to remotely activate specific brain circuits in fruit flies in under one second.

15 Jul 2022

U-M researchers reveal how a mutated protein acts as risk factor in Parkinson’s disease

In about a fifth of the cases of Parkinson’s disease, look to a small, malfunctioning protein in the lysosome as a risk factor, say University of Michigan researchers.

23 Jun 2022

New electrical test to screen individuals at risk of sudden cardiac arrest

New research from the Victor Chang Cardiac Research Institute will allow families around the world to discover if they are carrying genetic mutations that cause sudden cardiac arrest – a condition that kills nine out of 10 victims.

9 Jun 2022

Metrion Biosciences appoints Dr Benedetta Montagnini as Head of European Business Development

Metrion Biosciences Limited (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Benedetta Montagnini as Head of European Business Development. Driven by the uptake of its ion channel discovery services, the appointment follows the recent creation of a Client Services team as Metrion expands its operations and enhanced drug discovery capabilities, internationally.

From Metrion Biosciences Limited 9 Jun 2022

Study sheds light on the molecular biology behind genetic epilepsy

Sometimes, even the alteration of a single nucleotide in a gene can cause serious disease. In a young boy with epilepsy, this kind of mutation has not just affected the functioning of the protein in question – it could also curb the functioning of several closely related proteins.

23 May 2022

Epilepsy drug inhibits the growth of NF1 tumors in mice

People with neurofibromatosis type 1 (NF1) develop tumors on nerves throughout their bodies. These tumors are usually benign -; meaning they don't spread to other parts of the body and are not considered life-threatening -; but they can still cause serious medical problems such as blindness, especially when they form in the brain and nerves.

19 May 2022

Potential antiviral targets in SARS-CoV-2

Researchers assessed potential targets in severe acute respiratory syndrome coronavirus 2.

6 May 2022

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

Researchers demonstrated that E proteins of β-coronaviruses could restrict HIV-1 infection.

30 Mar 2022

New device based on concert hall acoustics enables noninvasive, ultrasound brain treatments

A team led by engineers at the University of California San Diego has developed a device that is a first step to enabling noninvasive, ultrasound-based therapies for the brain.

23 Mar 2022

Exploring the oligomerizing behavior of SARS-CoV-2 accessory protein 7b

Researchers tested the hypothesis that severe SARS-CoV-2 accessory protein 7b forms oligomers with ion channel activity in lipid and detergent environments.

23 Mar 2022

Malaria drug could help treat chemotherapy-resistant head and neck cancers

A new study suggests that the malaria drug hydroxychloroquine inhibits pathways that drive resistance to the chemotherapy agent cisplatin in head and neck cancers and restores tumor-killing effects of cisplatin in animal models.

14 Mar 2022

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Amino acids are the basic building blocks of living organisms and typically occur in a configuration known as the L-form. However, there are a few exceptional examples of the structural mirror image of the L-form (known as the D-form) being present in animals.

11 Mar 2022

TTUHSC expert wins NIH renewal grant to continue research on neurological disorders

According to the Global Burden of Disease study, neurological disorders are the leading cause of disability and the second leading cause of death after heart disease.

21 Feb 2022

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Researchers used cryo-EM to demonstrate that 1PBC, and the drug niclosamide, both inhibitors of TMEM16 proteins, have therapeutic potential and may be used for COVID-19 treatment.

14 Feb 2022

Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a complex and life-threatening vascular disease with high incidence worldwide. Termed the silent killer, most AAAs are asymptomatic, often going undetected until rupture, and involve a poorly understood set of mechanical and biochemical events.

28 Jan 2022

Ion Channel News and Research

Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

New wireless technology remotely activates specific brain circuits in under one second

U-M researchers reveal how a mutated protein acts as risk factor in Parkinson’s disease

New electrical test to screen individuals at risk of sudden cardiac arrest

Metrion Biosciences appoints Dr Benedetta Montagnini as Head of European Business Development

Study sheds light on the molecular biology behind genetic epilepsy

Epilepsy drug inhibits the growth of NF1 tumors in mice

Potential antiviral targets in SARS-CoV-2

Study shows that the SARS-CoV-2 envelope protein potently restricts HIV-1 infection

New device based on concert hall acoustics enables noninvasive, ultrasound brain treatments

Exploring the oligomerizing behavior of SARS-CoV-2 accessory protein 7b

Malaria drug could help treat chemotherapy-resistant head and neck cancers

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

TTUHSC expert wins NIH renewal grant to continue research on neurological disorders

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

COPD: Ion channels in immune cells could potentially be targets for new therapies

Manipulating voltage patterns in tumor cells reduces breast cancer metastasis in animal models

Research may pave the way for designing new therapies to combat schistosomiasis

Metrion Biosciences expands ion channel drug discovery service capabilities and in-house expertise

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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