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Scientists discover culprit in reducing effectiveness of insulin

Scientists at Osaka University discovered that Stromal derived factor-1 (SDF-1) secreted from adipocytes reduced the effectiveness of insulin in adipocytes and decreased insulin-induced glucose uptake.

25 Apr 2018

Receptors crucial for establishing strong memories

When we create a memory, a pattern of connections forms between neurons in the brain. New work from UC Davis shows how these connections can be strengthened or weakened at a molecular level. The study is published Feb. 27 in the journal Cell Reports.

27 Feb 2018

Researchers discover potential new antimalarial treatment targets

Researchers have discovered crucial new processes that allow malaria parasites to escape red blood cells and infect other cells, offering potential new treatment targets.

20 Feb 2018

Research findings could help develop new drugs to prevent, treat dry eye disease

With computers, smartphones and contact lenses now essential to modern life, many -- one out of every 10 Japanese people -- suffer dry eye disease.

20 Feb 2018

Scientists explore connection between bad sleep habits and stiff blood vessels

What do bad sleep habits and stiff blood vessels have in common? Nothing good, say scientists exploring what appears to be a direct connection between a circadian clock that isn't working as it should and an enzyme that promotes inflammation working overtime.

20 Feb 2018

Key proteins could help in controlling the risk of osteoarthritis during aging, Study finds

New study reveals that FOXO proteins help maintain healthy cells in the cartilage of the joints.

15 Feb 2018

TSRI study reveals potential strategy to prevent, treat osteoarthritis during aging

More than 30 million Americans suffer from osteoarthritis making it one of the most common age-related diseases.

15 Feb 2018

MGH researchers discover that macrophages contribute to untreatable type of heart failure

A team of Massachusetts General Hospital investigators has discovered, for the first time, that the immune cells called macrophages contribute to a type of heart failure for which there currently is no effective treatment.

14 Feb 2018

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

In cancer research, the “Cas-9–sgRNA” complex is an effective genomic editing tool, but its delivery across the cell membrane to the target (tumor) genome has not yet been satisfactorily solved. American and Danish scientists have now developed an active nanomotor for the efficient transport, delivery, and release of this gene scissoring system.

9 Feb 2018

Cholesterol and other lipids in the blood play role in many diseases

Lipids are fatty molecules that play important signaling and storage roles in the body, but having an excess of some lipids, like cholesterol, is a risk factor for many metabolic diseases.

8 Feb 2018

Human iPS cell-derived inner ear cells may improve hereditary hearing loss

A Japanese research group has successfully grafted human iPS cell-derived inner ear cells that express human-derived proteins into the inner ears of embryonic mice.

8 Feb 2018

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Researchers are closer to solving the puzzle of a complex neurological condition called 15q13.3 microdeletion syndrome. Individuals with this condition are missing a small piece of chromosome 15 that usually contains six genes, but which one of the genes is responsible for the clinical characteristics of patients has not been clear.

2 Feb 2018

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

New research from Sanford Burnham Prebys Medical Discovery Institute is among the first to describe how an mRNA modification impacts the life of neural stem cells.

24 Jan 2018

Chinese researchers develop multifunctional vehicle to transport gene therapeutics

Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the "gene scissors" to the tumor cell genome.

22 Jan 2018

Research provides insights into mechanisms governing healthy longevity

Keio University Global Research Institute, Tokyo publishes the January 2018 issue of KGRI Research Frontiers that includes researcher video profiles of Keio University researchers and research highlights from high impact publications including 'Regenerative medicine needs collaboration in and out of science in order to face current and future challenges; ‘Does eating fish protect you from depression?’; ‘Insights into the molecular mechanisms leading to kidney dysfunction in diabetic patients’; and ‘Ageing to 100 and beyond: Insights from demographic, phenotypic and genetic studies.

12 Jan 2018

Studies reveal possibility for memory T cells to serve a dual purpose

Scientists of two new complementary studies researching mice and humans claim that they have the strongest evidence yet that memory T cells responsible for long-term immune protection also serve an additional role.

14 Dec 2017

Selectively deleting stem cell factor promotes recovery after TBI in mice

UT Southwestern molecular biologists today report the unexpected finding that selectively deleting a stem cell transcription factor in adult mice promotes recovery after traumatic brain injury (TBI).

17 Nov 2017

Early intervention may be crucial to successful treatment of Friedreich's ataxia

New research published today in Disease Models & Mechanisms indicates that early intervention should be a key target in the development of new therapeutics for Friedreich's ataxia, as current treatments may be administered too late to target the disease effectively.

8 Nov 2017

New discovery in beta-cell pathway shows potential to improve effectiveness of diabetes drugs

Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes.

8 Nov 2017

Penn study sheds light on genetic cause of early hearing loss

From the moment a baby is born, they are put through a battery of screenings to test for all sorts of characteristics, which includes the sense of hearing.

26 Oct 2017

Knockout News and Research

Scientists discover culprit in reducing effectiveness of insulin

Receptors crucial for establishing strong memories

Researchers discover potential new antimalarial treatment targets

Research findings could help develop new drugs to prevent, treat dry eye disease

Scientists explore connection between bad sleep habits and stiff blood vessels

Key proteins could help in controlling the risk of osteoarthritis during aging, Study finds

TSRI study reveals potential strategy to prevent, treat osteoarthritis during aging

MGH researchers discover that macrophages contribute to untreatable type of heart failure

Scientists develop ultrasound-propelled nanomotors for active delivery of Cas9-sgRNA complex

Cholesterol and other lipids in the blood play role in many diseases

Human iPS cell-derived inner ear cells may improve hereditary hearing loss

Researchers move closer to solving puzzle of 15q13.3 microdeletion syndrome

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

Chinese researchers develop multifunctional vehicle to transport gene therapeutics

Research provides insights into mechanisms governing healthy longevity

Studies reveal possibility for memory T cells to serve a dual purpose

Selectively deleting stem cell factor promotes recovery after TBI in mice

Early intervention may be crucial to successful treatment of Friedreich's ataxia

New discovery in beta-cell pathway shows potential to improve effectiveness of diabetes drugs

Penn study sheds light on genetic cause of early hearing loss

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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