Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Preclinical study validates crucial role of the spleen in cardiac repair

Although we can survive without a spleen, evidence continues to mount that this abdominal organ plays a more valuable role in our physiological defenses than previously suspected.

23 Aug 2021

ICL fluorescent label homogenously penetrates the glioblastoma brain tumors

Fluorescent indocarbocyanine lipid (ICL) shows much better distribution within glioblastoma brain tumors compared to fluorescent phospholipids, according to a study published in ACS Nano.

23 Aug 2021

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Bacteria known as group B Streptococcus (GBS) are a common cause of blood infections, meningitis and stillbirth in newborns. Although GBS infections can often be treated or prevented with antibiotics, the bacteria are becoming increasingly resistant.

23 Aug 2021

Study in dogs may lead to better understanding of how gliomas affect the immune system

A new study reveals that high-grade gliomas, or brain tumors, in dogs contained more immune cells associated with suppressing immune response than low-grade gliomas.

20 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

A new study has determined the production of the SARS-CoV-2 SP-dependent ORF8.

18 Aug 2021

Severe COVID-19 characterized by phosphorylation of STAT1

A new study reports an enhanced expression of STAT1 in mild and severely infected COVID-19 patients as compared to controls

18 Aug 2021

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

A form of cell communication called hedgehog signaling is vital for embryonic development in mammals.

16 Aug 2021

Treatment with stem cell grafts promotes tendon healing in sheep

Tendon injuries in sheep that were treated with stem cell grafts achieved, in just two months, a diameter and hardness similar to the original healthy tendon, according to the results of a study released in STEM CELLS Translational Medicine.

16 Aug 2021

Research suggests toll-like receptor 4 appears to play role in severe COVID

A group of researchers re-evaluated their previously proposed hypothesis, which stated that the TLR4 activated by the spike glycoprotein S1 domain increases ACE2 expression and, thereby, aids in COVID-19 infection.

16 Aug 2021

New research offers hope to increase efficacy of immunotherapy for lung cancer

Lung cancer is the leading cause of cancer-related death. Current treatments employ immunotherapy, often in combination with chemotherapy, but benefits to patients remain slight.

11 Aug 2021

Defective process in the development of RBCs may trigger lupus

The autoimmune disease lupus may be triggered by a defective process in the development of red blood cells (RBCs), according to a study led by researchers at Weill Cornell Medicine.

11 Aug 2021

Hypoxic inflammation leads to inefficient cardiac repair after heart attacks

Activation of hypoxia inducible factors (green) in macrophages (purple) that have infiltrated damaged cardiac tissue (right) in heart tissue.

10 Aug 2021

New technique can be used to directly image atherosclerotic plaques

If heart attacks blared a warning signal, patients would have a better chance of avoiding them. That's the idea behind a new imaging technique developed by a Spartan-led team of researchers.

9 Aug 2021

Light therapy may speed up the healing of burns by activating growth protein

Light therapy may accelerate the healing of burns, according to a University at Buffalo-led study.

6 Aug 2021

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

A new study has revealed the mechanism by which the SARS-CoV-2 N protein activates NLRP3 inflammasomes to induce hyperinflammation.

5 Aug 2021

Immune system signaling molecule promotes the production of energy-burning 'beige fat'

An immune signal promotes the production of energy-burning "beige fat," according to a new study publishing August 5th in the open-access journal PLOS Biology by Zhonghan Yang of Sun Yat-Sen University, Guangzhou, China, and colleagues.

5 Aug 2021

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

Modified mRNA combined with lipid nanoparticles may be beneficial in boosting adaptive immunity against SARS-CoV-2. Research led by Botond Z. Igyártó from Thomas Jefferson University’s Department of Microbiology and Immunology in Pennsylvania recently found that the lipid nanoparticles induce protective adaptive immune responses with antibody titers against lethal doses of the virus.

5 Aug 2021

The role of natural killer cells in the fight against coronavirus infection

This study proposes a mathematical framework to analyze the effect of the viruses on type I interferon (IFN-I) signaling, which is part of the innate immune response. IFN-I brings about natural killer cell activation, which in turn causes the activation of macrophages.

4 Aug 2021

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells.

4 Aug 2021

Macrophage News and Research

Further Reading

Preclinical study validates crucial role of the spleen in cardiac repair

ICL fluorescent label homogenously penetrates the glioblastoma brain tumors

Human milk oligosaccharides may help treat or prevent bacterial infections in newborns and adults

Study in dogs may lead to better understanding of how gliomas affect the immune system

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

Severe COVID-19 characterized by phosphorylation of STAT1

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

Treatment with stem cell grafts promotes tendon healing in sheep

Research suggests toll-like receptor 4 appears to play role in severe COVID

New research offers hope to increase efficacy of immunotherapy for lung cancer

Defective process in the development of RBCs may trigger lupus

Hypoxic inflammation leads to inefficient cardiac repair after heart attacks

New technique can be used to directly image atherosclerotic plaques

Light therapy may speed up the healing of burns by activating growth protein

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

Immune system signaling molecule promotes the production of energy-burning 'beige fat'

How does the mRNA/lipid nanoparticle platform promote protective adaptive immunity against SARS-CoV-2?

The role of natural killer cells in the fight against coronavirus infection

Study provides new insights for understanding dynamic changes in immune responses to COVID-19

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