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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Researchers investigate link between serum cotinine and periodontitis among U.S. non-smokers

Researchers investigate link between serum cotinine and periodontitis among U.S. non-smokers

Today at the 93rd General Session and Exhibition of the International Association for Dental Research, researcher Aderonke A. Akinkugbe, University of North Carolina at Chapel Hill, USA, will present a study titled "Environmental Tobacco Smoke is Associated With Periodontitis in U.S. Non-smokers." [More]
Blood gas testing: an interview with David Stein, PhD, CEO, Point of Care, Siemens Healthcare Diagnostics

Blood gas testing: an interview with David Stein, PhD, CEO, Point of Care, Siemens Healthcare Diagnostics

The industry term ‘blood gas testing’ has come to mean the accurate measurement and reporting of a wide menu of blood parameters, all on a single platform. [More]
Chronic heart failure patients with decreased calcitriol may benefit from aggressive supplementation

Chronic heart failure patients with decreased calcitriol may benefit from aggressive supplementation

In patients with chronic heart failure, the vitamin D metabolite 1,25-dihydroxyvitamin D (1,25(OH)2D), also called calcitriol, and its ratio to parathyroid hormone (PTH 1-84) may help predict cardiovascular death; and patients with decreased calcitriol and decreased ratio of calcitriol to PTH might benefit from more aggressive supplementation, a new study finds. [More]
Two persistent organic environmental pollutants affect infant growth

Two persistent organic environmental pollutants affect infant growth

Even though the levels of two environmental pollutants have declined over the last 20 years, they may still have adverse effects on children's development, according to a new study by the Norwegian Institute of Public Health. This is the largest study of environmental pollutants and infant growth to date. [More]
Scientists confirm relation between levels of certain pollutants in the body and levels of obesity

Scientists confirm relation between levels of certain pollutants in the body and levels of obesity

A team of Spanish scientists, which includes several researchers from the University of Granada, has confirmed that there is a relation between the levels of certain environmental pollutants that a person accumulates in his or her body and their level of obesity. Subjects with more pollutants in their organisms present besides higher levels of cholesterol and triglycerides, which are important risk factors for cardiovascular disease. [More]
Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Nicotine's primary metabolite supports learning and memory by amplifying the action of a primary chemical messenger involved in both, researchers report. [More]
Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. [More]
BHB compound produced during dieting blocks part of immune system involved in inflammatory disorders

BHB compound produced during dieting blocks part of immune system involved in inflammatory disorders

Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer's disease. [More]
Microbes prevent malnutrition in fruit flies - and maybe humans too

Microbes prevent malnutrition in fruit flies - and maybe humans too

A study by scientists from the Florida campus of The Scripps Research Institute (TSRI) sheds significant new light on a surprising and critical role that microbes may play in nutritional disorders such as protein malnutrition.

Using fruit flies—Drosophila melanogaster—as a simple and easily studied stand-in for humans, these new findings advance our understanding of the fundamental mechanisms underlying microbial contributions to metabolism and may point to long-term strategies to treat and prevent malnutrition in general. [More]
TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

Scientists from the Florida campus of The Scripps Research Institute have for the first time discovered a killing mechanism that could underpin a range of the most intractable neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS. [More]
'Mad Cow' discovery points to possible neuron killing mechanism behind alzheimer’s and parkinson’s diseases

'Mad Cow' discovery points to possible neuron killing mechanism behind alzheimer’s and parkinson’s diseases

The new study, published recently in the journal Brain, revealed the mechanism of toxicity of a misfolded form of the protein that underlies prion diseases, such as bovine spongiform encephalopathy (“mad cow disease”) and its human equivalent, Creutzfeldt-Jakob disease. [More]
New study heightens concerns over the detrimental impact of APOE ε4 in urban children

New study heightens concerns over the detrimental impact of APOE ε4 in urban children

A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer's disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens. [More]
Study opens door for development of tools to modulate CoQ10 synthesis in human cells

Study opens door for development of tools to modulate CoQ10 synthesis in human cells

A study which counts with the participation of University of Granada scientists has provided new data on the Q10 coenzyme (CoQ10), a molecule which is synthesized within the cells of the organism itself and which has essential functions for cellular metabolism. [More]
Study: Common pesticide may alter the development of brain's dopamine system

Study: Common pesticide may alter the development of brain's dopamine system

A commonly used pesticide may alter the development of the brain's dopamine system -- responsible for emotional expression and cognitive function - and increase the risk of attention deficit hyperactivity disorder in children, according to a new Rutgers study. [More]
New experimental study shows immunotherapy can reduce acute effects of heroin

New experimental study shows immunotherapy can reduce acute effects of heroin

Immunotherapy could have a place in the treatment of substance abuse in the future. A specific antibody can reduce the acute effects of heroin, according to a new experimental study at the Norwegian Institute of Public Health. [More]
Study: Century-old drug may help treat autism

Study: Century-old drug may help treat autism

Autism spectrum disorders (ASD) affect 1 to 2 percent of children in the United States. Hundreds of genetic and environmental factors have been shown to increase the risk of ASD. Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice. [More]
UCSD nanoengineers develop temporary tattoo to measure glucose levels

UCSD nanoengineers develop temporary tattoo to measure glucose levels

Nanoengineers at the University of California, San Diego have tested a temporary tattoo that both extracts and measures the level of glucose in the fluid in between skin cells. This first-ever example of the flexible, easy-to-wear device could be a promising step forward in noninvasive glucose testing for patients with diabetes. [More]
How quickly smokers metabolise nicotine may point to best quitting method

How quickly smokers metabolise nicotine may point to best quitting method

The success of different smoking cessation treatments could be predicted by how quickly smokers break down (metabolise) nicotine in their bodies, according to new research published in The Lancet Respiratory Medicine journal. [More]
Tobacco smoke toxin could increase pain in people with spinal cord injury

Tobacco smoke toxin could increase pain in people with spinal cord injury

A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period. [More]
New drug shows promise against treatment-resistant non-small cell lung cancer

New drug shows promise against treatment-resistant non-small cell lung cancer

A new drug that targets not only common cancer-causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I/II clinical trial. [More]
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