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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Research unlocks potential new therapies for inflammatory diseases

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue. [More]
Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Researchers identify metabolite that promotes epithelial-mesenchymal transition of colorectal cancer cells

Osaka University researchers revealed that the metabolite D-2-hydroxyglurate (D-2HG) promotes epithelial-mesenchymal transition of colorectal cancer cells, leading them to develop features of lower adherence to neighboring cells, increased invasiveness, and greater likelihood of metastatic spread. [More]
Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers at Indiana University's Biocomplexity Institute have developed a virtual model of the human liver to better understand how the organ metabolizes acetaminophen, a common non-prescription painkiller and fever-reducer used in over-the-counter drugs such as Tylenol. [More]
Metabolomics research at the Phenome Centre Birmingham

Metabolomics research at the Phenome Centre Birmingham

The new Phenome Centre Birmingham is an eight-million-pound research facility that has been funded by the Medical Research Council, by the University of Birmingham, and by four industry partners, namely, Beckman Coulter, Bruker, ThermoFisher Scientific and Waters. It is a clinical phenotyping centre. [More]
Stuttering linked to changes in speech and language-based brain circuits

Stuttering linked to changes in speech and language-based brain circuits

Researchers at Children's Hospital Los Angeles have conducted the first study of its kind, using proton magnetic resonance spectroscopy (MRS) to look at brain regions in both adults and children who stutter. [More]
Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Researchers develop new rapid diagnostic test for cocaine in urine and oral fluid

Academics in the University of Surrey's Department of Chemistry have developed a new diagnostic test for cocaine and benzoylecgonine (the main metabolite for cocaine) in urine and oral fluid. [More]
New bioinformatic framework identifies protein that plays key role in diabetic kidney disease

New bioinformatic framework identifies protein that plays key role in diabetic kidney disease

A new bioinformatic framework developed by researchers at University of California San Diego School of Medicine has identified key proteins significantly altered at the gene-expression level in biopsied tissue from patients with diabetic kidney disease, a result that may reveal new therapeutic targets. [More]
Researchers develop new blood test that can accurately diagnose concussions

Researchers develop new blood test that can accurately diagnose concussions

Scientists from Children's Health Research Institute, a program of Lawson Health Research Institute, and Western University have developed a new blood test that identifies with greater than 90 per cent certainty whether or not an adolescent athlete has suffered a concussion. [More]
Researchers identify potential approach for preventing neurological problems caused by blast-related TBI

Researchers identify potential approach for preventing neurological problems caused by blast-related TBI

More than 200,000 U.S. soldiers serving in the Middle East have experienced a blast-related traumatic brain injury, making it a common health problem and concern for that population. [More]
Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Current initiatives within the biopharmaceutical industry to adopt PAT (Process Analytical Technology) approaches in manufacturing, include activities in early process development. [More]
Choline deficiency in sows during pregnancy impacts nutrient composition of milk

Choline deficiency in sows during pregnancy impacts nutrient composition of milk

Choline is an essential nutrient that is used by the body in a number of ways. However, nearly 90 percent of adults do not get the recommended amount in their diets. [More]
Researchers develop MRI-based method that can track progression of genetically mutated gliomas

Researchers develop MRI-based method that can track progression of genetically mutated gliomas

UT Southwestern Medical Center researchers have developed an MRI-based method that can track the state and progression of a common type of genetically mutated brain cancer. [More]
New lab-on-a-chip system can detect effects of toxic substances on hemoglobin in blood

New lab-on-a-chip system can detect effects of toxic substances on hemoglobin in blood

A new lab-on-a-chip system, developed by the University of Twente in The Netherlands, is capable of fast analysis of the effects of toxic substances on hemoglobin, for example. It mimicks human metabolism. [More]
Unknown exposure to second-hand smoke linked to increased mortality in non-smokers

Unknown exposure to second-hand smoke linked to increased mortality in non-smokers

A new biomarker has identified known and unknown exposure to second-hand smoke and confirmed a strong association to increased mortality in non-smokers, according to a new study from the Icahn School of Medicine at Mount Sinai. [More]
Maternal serum levels of nicotinamide linked to child’s risk of atopic eczema

Maternal serum levels of nicotinamide linked to child’s risk of atopic eczema

Infants whose mothers had a higher level of a particular type of vitamin B during pregnancy have a lower risk of eczema at age 12 months, new Southampton research has shown. [More]
Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways. [More]
Researchers describe how genetic mutations cause unnamed neurological disorder

Researchers describe how genetic mutations cause unnamed neurological disorder

In rare cases -- for instance, among siblings in two families from Pakistan and Oman described in a new study -- children have been born with an unnamed neurological disorder. [More]
ToMMo scientists identify genetic variants affecting enzymatic activities in healthy people

ToMMo scientists identify genetic variants affecting enzymatic activities in healthy people

Scientists from Tohoku University's Tohoku Medical Megabank Organization have published research about genetic diversity and metabolome in Scientific Reports. [More]
Whitehead Institute scientists develop novel method for profiling mitochondrial metabolites

Whitehead Institute scientists develop novel method for profiling mitochondrial metabolites

Whitehead Institute scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within the cellular organelles known as mitochondria, often referred to as the "powerhouses of the cell." [More]
CFS possesses objectively identifiable chemical signature in men and women, study reveals

CFS possesses objectively identifiable chemical signature in men and women, study reveals

Dauer is the German word for persistence or long-lived. It is a type of stasis in the development in some invertebrates that is prompted by harsh environmental conditions. The findings are published online in the August 29 issue of PNAS. [More]
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