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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Scientists confirm relation between levels of certain pollutants in the body and levels of obesity

Scientists confirm relation between levels of certain pollutants in the body and levels of obesity

A team of Spanish scientists, which includes several researchers from the University of Granada, has confirmed that there is a relation between the levels of certain environmental pollutants that a person accumulates in his or her body and their level of obesity. Subjects with more pollutants in their organisms present besides higher levels of cholesterol and triglycerides, which are important risk factors for cardiovascular disease. [More]
Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Nicotine metabolite supports learning, memory by amplifying action of primary chemical messenger

Nicotine's primary metabolite supports learning and memory by amplifying the action of a primary chemical messenger involved in both, researchers report. [More]
Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Gut microbial metabolite of linoleic acid has suppressive effect on intestinal inflammation

Inflammatory bowel diseases (IBDs), including Crohn disease and ulcerative colitis, are hard to completely cure. Globally, IBDs affect more than 4 million people, today. However, Professor Soichi Tanabe (Graduate School of Biosphere Science, Hiroshima University) and his collaborators have demonstrated that 10-hydroxy-cis-12-octadecenoic acid (HYA), a gut microbial metabolite of linoleic acid, has a suppressive effect on intestinal inflammation. [More]
BHB compound produced during dieting blocks part of immune system involved in inflammatory disorders

BHB compound produced during dieting blocks part of immune system involved in inflammatory disorders

Researchers at Yale School of Medicine have found that a compound produced by the body when dieting or fasting can block a part of the immune system involved in several inflammatory disorders such as type 2 diabetes, atherosclerosis, and Alzheimer's disease. [More]
TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

TSRI scientists discover novel mechanism involved in Alzheimer's, Parkinson's and ALS

Scientists from the Florida campus of The Scripps Research Institute have for the first time discovered a killing mechanism that could underpin a range of the most intractable neurodegenerative diseases such as Alzheimer's, Parkinson's and ALS. [More]
New study heightens concerns over the detrimental impact of APOE ε4 in urban children

New study heightens concerns over the detrimental impact of APOE ε4 in urban children

A new study by researchers at the Universities of Montana, Carleton, and North Carolina, and the Centro de Ciencias de la Atmósfera, Universidad Nacional Autónoma de México, heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele -- the most prevalent genetic risk for Alzheimer's disease -- upon cognition, olfaction, and metabolic brain indices in healthy urban children and teens. [More]
Study opens door for development of tools to modulate CoQ10 synthesis in human cells

Study opens door for development of tools to modulate CoQ10 synthesis in human cells

A study which counts with the participation of University of Granada scientists has provided new data on the Q10 coenzyme (CoQ10), a molecule which is synthesized within the cells of the organism itself and which has essential functions for cellular metabolism. [More]
Study: Common pesticide may alter the development of brain's dopamine system

Study: Common pesticide may alter the development of brain's dopamine system

A commonly used pesticide may alter the development of the brain's dopamine system -- responsible for emotional expression and cognitive function - and increase the risk of attention deficit hyperactivity disorder in children, according to a new Rutgers study. [More]
New experimental study shows immunotherapy can reduce acute effects of heroin

New experimental study shows immunotherapy can reduce acute effects of heroin

Immunotherapy could have a place in the treatment of substance abuse in the future. A specific antibody can reduce the acute effects of heroin, according to a new experimental study at the Norwegian Institute of Public Health. [More]
Study: Century-old drug may help treat autism

Study: Century-old drug may help treat autism

Autism spectrum disorders (ASD) affect 1 to 2 percent of children in the United States. Hundreds of genetic and environmental factors have been shown to increase the risk of ASD. Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice. [More]
UCSD nanoengineers develop temporary tattoo to measure glucose levels

UCSD nanoengineers develop temporary tattoo to measure glucose levels

Nanoengineers at the University of California, San Diego have tested a temporary tattoo that both extracts and measures the level of glucose in the fluid in between skin cells. This first-ever example of the flexible, easy-to-wear device could be a promising step forward in noninvasive glucose testing for patients with diabetes. [More]
How quickly smokers metabolise nicotine may point to best quitting method

How quickly smokers metabolise nicotine may point to best quitting method

The success of different smoking cessation treatments could be predicted by how quickly smokers break down (metabolise) nicotine in their bodies, according to new research published in The Lancet Respiratory Medicine journal. [More]
Tobacco smoke toxin could increase pain in people with spinal cord injury

Tobacco smoke toxin could increase pain in people with spinal cord injury

A neurotoxin called acrolein found in tobacco smoke that is thought to increase pain in people with spinal cord injury has now been shown to accumulate in mice exposed to the equivalent of 12 cigarettes daily over a short time period. [More]
New drug shows promise against treatment-resistant non-small cell lung cancer

New drug shows promise against treatment-resistant non-small cell lung cancer

A new drug that targets not only common cancer-causing genetic mutations in patients with non-small cell lung cancer (NSCLC), but also a form of the mutation that causes resistance to treatment, has shown promising results in patients in a phase I/II clinical trial. [More]
Scientists discover ways to detect several toxic flame retardants in people's bodies

Scientists discover ways to detect several toxic flame retardants in people's bodies

A new peer-reviewed study found that people are contaminated with several toxic flame retardants rarely studied in the US, including one that has never before been detected in Americans called TCEP. Scientists tested urine samples of California residents for biomarkers of six chemicals, all of which were present. [More]
Changes in cell metabolism slow growth of colorectal cancer

Changes in cell metabolism slow growth of colorectal cancer

Cancer is an unwanted experiment in progress. As the disease advances, tumor cells accumulate mutations, eventually arriving at ones that give them the insidious power to grow uncontrollably and spread. Distinguishing drivers of cancer from benign mutations open opportunities for developing targeted cancer therapies. [More]
Prenatal exposure to phthalate DiNP associated with shorter AGD in Swedish boys: Study

Prenatal exposure to phthalate DiNP associated with shorter AGD in Swedish boys: Study

The first study to examine prenatal exposure to the phthalate DiNP finds it is associated with a shorter anogenital distance (AGD) in Swedish boys at the age of 21 months. These findings raise concern since animal research has linked DiNP exposure to a shorter AGD, and studies on humans have related shorter AGD to male genital birth defects as well as impaired reproductive function in adult males, and the levels of DiNP metabolites in humans are increasing globally. [More]
Autism Speaks grants $1M to Children's Hospital Los Angeles to improve GI symptoms associated with ASD

Autism Speaks grants $1M to Children's Hospital Los Angeles to improve GI symptoms associated with ASD

Pat Levitt, PhD, Simms/Mann Chair in Developmental Neurogenetics at Children's Hospital Los Angeles, has received a grant of nearly $1 million from Autism Speaks, the world's leading autism science and advocacy organization. [More]
Novel approach may help detect invasive aspergillosis

Novel approach may help detect invasive aspergillosis

Many different microbes can cause pneumonia, and treatment may be delayed or off target if doctors cannot tell which bug is the culprit. A novel approach—analyzing a patient's breath for key chemical compounds made by the infecting microbe—may help detect invasive aspergillosis, a fungal infection that is a leading cause of mortality in patients with compromised immune systems, according to a proof-of-concept study now online in Clinical Infectious Diseases. [More]
Eating high-protein breakfast reduces food cravings, overeating later on

Eating high-protein breakfast reduces food cravings, overeating later on

According to the Centers for Disease Control and Prevention, many teens skip breakfast, which increases their likelihood of overeating and eventual weight gain. Statistics show that the number of adolescents struggling with obesity, which elevates the risk for chronic health problems, has quadrupled in the past three decades. [More]