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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Researchers identify novel biomarkers for predicting mortality in ICU patients

Researchers identify novel biomarkers for predicting mortality in ICU patients

A metabolic profile of intensive care unit patients based on biomarkers of four metabolites can be used to accurately predict mortality, according to a new study. [More]
Cell Therapeutics announces issuance of final benefit assessment report for PIXUVRI

Cell Therapeutics announces issuance of final benefit assessment report for PIXUVRI

Cell Therapeutics, Inc. today reported that Germany's Federal Joint Committee has issued its final benefit assessment report for PIXUVRI (pixantrone), which is indicated as a monotherapy for the treatment of adult patients with aggressive B-cell non-Hodgkin lymphoma (NHL) who have failed two or three prior lines of therapy. [More]
Elixir Medical receives FDA approval to initiate patient enrollment in EXCELLA III clinical trial in US

Elixir Medical receives FDA approval to initiate patient enrollment in EXCELLA III clinical trial in US

Elixir Medical Corporation, a developer of products that combine state-of-the-art medical devices with advanced pharmaceuticals, announced today that it has received approval from the Food and Drug Administration to initiate patient enrollment in the EXCELLA III clinical trial in the United States at up to 50 institutions with conditions to be addressed in parallel. [More]
Aerobic exercise can help reduce breast cancer risk

Aerobic exercise can help reduce breast cancer risk

Changes in estrogen breakdown, or metabolism, may be one of the mechanisms by which aerobic exercise lowers a woman's breast cancer risk, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. [More]
Case report reveals that sugar substitutes may adversely affect endocrine health

Case report reveals that sugar substitutes may adversely affect endocrine health

It's a known fact that drinking too many sugary drinks can lead to obesity and diabetes, but sugar substitutes may adversely affect your endocrine health, according to a case report presented at the American Association of Clinical Endocrinologists 22nd Annual Scientific and Clinical Congress. [More]
Study may pave way for new strategies to fight cancer cells

Study may pave way for new strategies to fight cancer cells

For the first time, researchers at Karolinska Institutet in Sweden have managed to obtain detailed images of the way in which the transport protein GLUT transports sugars into cells. [More]
Study demonstrates accuracy of non-invasive test for NASH diagnosis

Study demonstrates accuracy of non-invasive test for NASH diagnosis

A Chinese study presented at the International Liver CongressTM 2013 has demonstrated the accuracy of a non-invasive test for non-alcoholic steatohepatitis (NASH) diagnosis. [More]
Urine tests could improve diagnosis of liver cancer

Urine tests could improve diagnosis of liver cancer

New data from two clinical trials presented today at the International Liver Congress- 2013 demonstrate substantial improvements in the detection of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) using diagnostic urine tests. [More]
Research shows association between cognition, brain activity in response to televised anti-smoking ads

Research shows association between cognition, brain activity in response to televised anti-smoking ads

Researchers from the Perelman School of Medicine at University of the Pennsylvania have shown that an area of the brain that initiates behavioral changes had greater activation in smokers who watched anti-smoking ads with strong arguments versus those with weaker ones, and irrespective of flashy elements, like bright and rapidly changing scenes, loud sounds and unexpected scenario twists. [More]

Higher TMAO blood levels linked to increased risk of heart disease

A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine. [More]
Cancer metabolism study identifies hundreds of alterations, potential drug targets to starve tumors

Cancer metabolism study identifies hundreds of alterations, potential drug targets to starve tumors

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. [More]

Study identifies potential drug targets that interfere with cancer metabolism

A massive study analyzing gene expression data from 22 tumor types has identified multiple metabolic expression changes associated with cancer. [More]

Pharmacological study shows interactions between drugs can be detected with minute doses

Clinical pharmacologists at Heidelberg University Hospital have achieved major progress for improving the reliability of drugs. In a pharmacological study, they showed for the first time that interactions between drugs can be detected with minute doses in the range of nanograms. [More]

Matrix-Bio, Quest Diagnostics enter global licensing agreement for metabolomic biomarkers

Matrix-Bio, Inc., a diagnostics company that uses metabolite profiling to detect cancer and other diseases, has signed an exclusive global licensing and marketing agreement for metabolomic biomarkers with Quest Diagnostics, the world's leading provider of diagnostic information services. Under the agreement, Quest Diagnostics will have the rights to use the biomarkers for the future, potential development of a clinical lab-developed test to aid in the detection of breast cancer recurrence. [More]
Research shows omega-3 fatty acids stop proliferation of triple-negative breast cancer cells

Research shows omega-3 fatty acids stop proliferation of triple-negative breast cancer cells

Researchers from Fox Chase Cancer Center have found that omega-3 fatty acids and their metabolite products slow or stop the proliferation, or growth in the number of cells, of triple-negative breast cancer cells more effectively than cells from luminal types of the disease. [More]
Study finds Google searches for information about mental illnesses, problems follow seasonal patterns

Study finds Google searches for information about mental illnesses, problems follow seasonal patterns

A new study published in the May issue of the American Journal of Preventive Medicine finds that Google searches for information across all major mental illnesses and problems followed seasonal patterns, suggesting mental illness may be more strongly linked with seasonal patterns than previously thought. [More]
Argentina's ANMAT approves AUBAGIO for patients with relapsing multiple sclerosis

Argentina's ANMAT approves AUBAGIO for patients with relapsing multiple sclerosis

Genzyme, a Sanofi company, announced today Argentina's National Administration of Drugs, Food and Medical Technology has approved once-daily, oral AUBAGIO 14 mg as a new treatment indicated for patients with relapsing forms of multiple sclerosis. [More]
Male smokers with low levels of serum bilirubin are at higher risk for lung cancer

Male smokers with low levels of serum bilirubin are at higher risk for lung cancer

Elevated levels of bilirubin in the blood get attention in the clinic because they often indicate that something has gone wrong with the liver. Now researchers have found that male smokers with low levels of the yellow-tinged chemical are at higher risk for lung cancer and dying from the disease. [More]

Carnitine compound in red meat and energy drinks increases risk for cardiovascular disease

A compound abundant in red meat and added as a supplement to popular energy drinks has been found to promote atherosclerosis - or the hardening or clogging of the arteries - according to Cleveland Clinic research published online this week in the journal Nature Medicine. [More]
UC Davis scientists find mechanism in metabolized omega-3 fatty acid that helps combat cancer

UC Davis scientists find mechanism in metabolized omega-3 fatty acid that helps combat cancer

A team of UC Davis scientists has found that a product resulting from a metabolized omega-3 fatty acid helps combat cancer by cutting off the supply of oxygen and nutrients that fuel tumor growth and spread of the disease. [More]