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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Nicotine, cotinine can potentially inhibit DNA damage caused by NNK in tobacco smoke

Nicotine, cotinine can potentially inhibit DNA damage caused by NNK in tobacco smoke

A new in vitro study has revealed that nicotine and cotinine, a metabolite of nicotine, can potentially inhibit DNA damage caused by a certain carcinogen in smoke. [More]
Right kind of fat keeps the heart healthy

Right kind of fat keeps the heart healthy

Too much dietary fat is bad for the heart, but the right kind of fat keeps the heart healthy, according to a paper published in The Journal of Experimental Medicine. [More]
New study finds highest rates of decline in prescription drug misuse nationwide

New study finds highest rates of decline in prescription drug misuse nationwide

Five states that have implemented multi-faceted prescription drug abuse prevention programs in recent years showed the highest rate of decline in prescription drug misuse rates nationwide, according to a new study issued today by Quest Diagnostics, the world's leading provider of diagnostic information services. [More]
Chemoprevention and colon cancer: an interview with Dr. John Letterio, Case Western Reserve University School of Medicine

Chemoprevention and colon cancer: an interview with Dr. John Letterio, Case Western Reserve University School of Medicine

The basic idea of cancer chemopre­vention is to arrest or reverse the progression of pre­malignant cells towards full malignancy, using physiological mechanisms that do not kill healthy cells. [More]
Study: Stress can disrupt process of fat tissue development

Study: Stress can disrupt process of fat tissue development

Using experimental models, researchers at Boston University School of Medicine (BUSM) showed that adenosine, a metabolite released when the body is under stress or during an inflammatory response, stops the process of adipogenesis, when adipose (fat) stem cells differentiate into adult fat cells. [More]
Mass spectrometry-based tool successfully used in brain cancer surgery

Mass spectrometry-based tool successfully used in brain cancer surgery

A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study. [More]
Backpack-sized device can perform highly accurate and sensitive cocaine testing in 15 minutes

Backpack-sized device can perform highly accurate and sensitive cocaine testing in 15 minutes

Testing for cocaine and other drugs usually involves two steps: a quick on-site prescreen, and then a more accurate confirmatory test at a distant laboratory. [More]
Adding MM-398 to standard treatment improves survival in metastatic pancreatic cancer patients

Adding MM-398 to standard treatment improves survival in metastatic pancreatic cancer patients

Adding the novel MM-398 to standard treatment for metastatic pancreatic cancer patients who have already received gemcitabine improves survival, researchers said at the ESMO 16th World Congress on Gastrointestinal Cancer in Barcelona. [More]
Small molecule in pregnant women's urine apparently blocks cancer growth

Small molecule in pregnant women's urine apparently blocks cancer growth

University of Montreal scientists have identified a small molecule found in pregnant women's urine that apparently blocks the growth of several types of cancers, including AIDS-related Kaposi's sarcoma, which currently has no cure. [More]
Debiopharm launches Phase 1 study of anti-infective agent Debio 1450

Debiopharm launches Phase 1 study of anti-infective agent Debio 1450

Debiopharm Group, a Swiss-based global biopharmaceutical company developing prescription drugs that target unmet medical needs as well as companion diagnostics, today announced the launch of a Phase 1 dose-escalation study of Debio 1450 (previously known as AFN-1720), a highly potent anti-infective agent that is selectively active against a large number of Staphylococcus species, including all known resistant strains such as methicillin-resistant S. aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). [More]

Double Emulsion System released by Dolomite

Microfluidic products expert Dolomite have released their Double Emulsion System for creating micron sized emulsion droplets that contain still smaller droplets inside. It enables unrivalled reproducibility and selectivity of droplet size of both outer and inner phases with either oil-in-water-in-oil or water-in-oil-in-water droplets. The Double Emulsion System is highly beneficial to applications in the food industry, in pharmaceuticals and cosmetics that use double emulsions as delivery vehicles or encapsulation solutions for various active ingredients, or more generally in paints and coatings. [More]
Progress in constructing protein nanomachines

Progress in constructing protein nanomachines

A route for constructing protein nanomachines engineered for specific applications may be closer to reality. [More]
A novel strategy to uncover new antibiotics

A novel strategy to uncover new antibiotics

Resistance to antibiotics has been steadily rising, posing a threat to public health. Now, a method from Mohammad Seyedsayamdost, an assistant professor of chemistry at Princeton University, may open the door to the discovery of a host of potential drug candidates. [More]
Corgenix announces that Randox received CE Mark notification for TxBCardio Assay

Corgenix announces that Randox received CE Mark notification for TxBCardio Assay

Corgenix Medical Corporation announced in collaboration with Randox Laboratories that Randox has been granted CE Mark notification for its TxBCardio™ Assay. [More]
Researchers develop chip-like device to sort, store and retrieve individual living cells for study

Researchers develop chip-like device to sort, store and retrieve individual living cells for study

A U.S. and Korean research team has developed a chip-like device that could be scaled up to sort and store hundreds of thousands of individual living cells in a matter of minutes. The system is similar to a random access memory chip, but it moves cells rather than electrons. [More]
Cell Therapeutics announces launch of PIXUVRI in the UK for treatment of aggressive B-cell NHL

Cell Therapeutics announces launch of PIXUVRI in the UK for treatment of aggressive B-cell NHL

Cell Therapeutics, Inc. today announced the launch of PIXUVRI (pixantrone), the first new treatment for adult patients in the United Kingdom (UK) with multiply relapsed or refractory aggressive B-cell non-Hodgkin lymphoma (aggressive B-cell NHL), at the 54th annual scientific meeting of the British Society for Haematology. [More]
Concert Pharmaceuticals reports results from CTP-499 Phase 2 trial in patients with diabetic kidney disease

Concert Pharmaceuticals reports results from CTP-499 Phase 2 trial in patients with diabetic kidney disease

Concert Pharmaceuticals, Inc. today announced 48-week results of its Phase 2 clinical trial of CTP-499 in patients with diabetic kidney disease. CTP-499, when used in addition to the standard of care, is being developed to delay the progression of these patients to end-stage renal failure, which requires dialysis or kidney transplantation. [More]
Princeton professor receives Agilent Thought Leader Award to research on cellular metabolism activity

Princeton professor receives Agilent Thought Leader Award to research on cellular metabolism activity

Agilent Technologies Inc. today announced that Joshua Rabinowitz, M.D., Ph.D., professor at Princeton University's Department of Chemistry and the Lewis-Sigler Institute for Integrative Genomics, has received an Agilent Thought Leader Award to support his work on quantitative analysis of cellular metabolism. [More]
Metabolon announces launch of fourth-generation metabolomics platform

Metabolon announces launch of fourth-generation metabolomics platform

Metabolon, Inc., a leader in metabolomics-driven biomarker discovery, announced today the launch of DiscoveryHD4, the company's fourth-generation metabolomics platform. [More]
Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Thorne Research today announced the launch of NiaCel™, an innovative nutritional supplement that supports endurance, energy, and healthy aging. [More]