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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Metabolon announces launch of fourth-generation metabolomics platform

Metabolon announces launch of fourth-generation metabolomics platform

Metabolon, Inc., a leader in metabolomics-driven biomarker discovery, announced today the launch of DiscoveryHD4, the company's fourth-generation metabolomics platform. [More]
Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Thorne Research launches NiaCel that supports endurance, energy and healthy aging

Thorne Research today announced the launch of NiaCel™, an innovative nutritional supplement that supports endurance, energy, and healthy aging. [More]

Aspartic acid in hippocampus may be biomarker for predicting occurrence of cognitive dysfunction

Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery, and manifests as impairments in short-term memory, concentration, language comprehension, and social integration skills. [More]
Vitamin D boosts survival of breast cancer patients

Vitamin D boosts survival of breast cancer patients

Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient, report University of California, San Diego School of Medicine researchers in the March issue of Anticancer Research. [More]
Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid metabolism and obesity: an interview with Dr. Namandjé Bumpus, Johns Hopkins Medicine

Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy. It has also been shown to be effective for the treatment of mood disorders and migraine headaches. [More]
First evidence of link between prenatal vitamin A deficiency and postnatal asthma

First evidence of link between prenatal vitamin A deficiency and postnatal asthma

A team of Columbia University Medical Center (CUMC) investigators led by Wellington V. Cardoso, MD, PhD, has found the first direct evidence of a link between prenatal vitamin A deficiency and postnatal airway hyperresponsiveness, a hallmark of asthma. [More]
Exposure to DDT may increase likelihood of developing Alzheimer's disease later in life

Exposure to DDT may increase likelihood of developing Alzheimer's disease later in life

Exposure to DDT may increase the likelihood of developing Alzheimer's disease later in life, a study with researchers at UT Southwestern Medical Center suggests. While previous studies have linked chronic diseases such as cancer and diabetes to DDT, this is the first clinical study to link the U.S.-banned pesticide to Alzheimer's disease. [More]
Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

Transgenic mouse model validates mutant IDH2 protein as candidate for targeted anticancer therapies

In recent years, mutations in two metabolic enzymes, isocitrate dehydrogenase-1 and 2 (IDH1 and IDH2), have been identified in approximately 20 percent of all acute myeloid leukemias (AML). As a result, mutant IDH proteins have been proposed as attractive drug targets for this common form of adult leukemia. [More]
Researchers test role of dietary supplement use in college students

Researchers test role of dietary supplement use in college students

Habits acquired during young adulthood are crucial in fostering lifelong health. Unfortunately, some college students fall into nutrient-deficient diets that leave them at risk for developing chronic disease later in life. [More]
Research may lead to potential treatment for deadly bacterial infections

Research may lead to potential treatment for deadly bacterial infections

Collaboration between the National University of Singapore (NUS) and The Hebrew University of Jerusalem (HUJ) on inflammation research may lead to a potential treatment for deadly bacterial infections [More]
New study examines factors that may lead to end stage renal disease

New study examines factors that may lead to end stage renal disease

About 33 percent of people with type 2 diabetes suffer kidney damage that progresses to end stage renal disease, at which point they require either dialysis or kidney transplantation. Scientists have thought that this kidney disease is driven by damage to the glomeruli, blood vessels in the kidney, which spill the protein albumin into the urine. Current treatments targeting the resulting "albuminuria" do not prevent kidney failure. [More]
More evidence for glutamate dysregulation in schizophrenia

More evidence for glutamate dysregulation in schizophrenia

Levels of glutamine, but not glutamate, are elevated in the dorsal anterior cingulate of patients with established schizophrenia, say researchers. [More]
MRI method to map creatine in heart may help detect disorders earlier than traditional methods

MRI method to map creatine in heart may help detect disorders earlier than traditional methods

A new MRI method to map creatine at higher resolutions in the heart may help clinicians and scientists find abnormalities and disorders earlier than traditional diagnostic methods, researchers at the Perelman School of Medicine at the University of Pennsylvania suggest in a new study published online today in Nature Medicine. [More]
Crowdsourcing fungal metabolites with antitumor activity: an interview with Dr. Robert H. Cichewicz, University of Oklahoma

Crowdsourcing fungal metabolites with antitumor activity: an interview with Dr. Robert H. Cichewicz, University of Oklahoma

Fungi have played a large role in the development of many important drugs that are in wide use today. The most well-known of these are the penicillins. [More]
NICE issues Final Appraisal Determination for PIXUVRI (pixantrone) drug

NICE issues Final Appraisal Determination for PIXUVRI (pixantrone) drug

Cell Therapeutics, Inc. (CTI) (NASDAQ and MTA: CTIC) today reported that the National Institute for Health and Care Excellence (NICE), the independent body responsible for driving improvement and excellence in the health and social care system in the United Kingdom (UK), has issued its Final Appraisal Determination (FAD) for PIXUVRI® (pixantrone). [More]

Researchers uncover new genetic clue that contributes to increased risk of type 2 diabetes

​An international team of researchers in Mexico and the United States has uncovered a new genetic clue that contributes to an increased risk of developing type 2 diabetes, particularly the elevated risk among Mexican and other Latin American populations. [More]

Z-endoxifen may provide better treatment for women with estrogen positive breast cancer

A Phase I trial of endoxifen, an active metabolite of the cancer drug tamoxifen, indicates that the experimental drug is safe, with early evidence for anti-tumor activity, a Mayo Clinic study has found. The findings indicate that Z-endoxifen, co-developed by Mayo Clinic Cancer Center and the National Cancer Institute, may provide a new and better treatment for some women with estrogen positive breast cancer and, in particular, for those women who do not respond to tamoxifen and aromatase inhibitors. [More]
Valuable new approach to cancer treatment

Valuable new approach to cancer treatment

Since the discovery of penicillin, fungi have been a nearly inexhaustible source for the discovery of new drugs. “Crowdsourcing”, the cooperation of a large number of interested nonscientists, has helped to find a new fungus from which American researchers have now isolated and characterized an unusual metabolite with interesting antitumor activity. [More]
High cholesterol fuels growth and spread of breast Cancer

High cholesterol fuels growth and spread of breast Cancer

Researchers at Duke Medicine conclude that high cholesterol may make breast cancer worse when they found that a byproduct of cholesterol functions like the hormone estrogen, leading to increases in the growth and spread of breast cancer. Studies have previously shown the link between obesity and breast cancer, but the exact cause of the increased risk had not been identified. [More]
Preparing for better management of Tamiflu-resistant influenza viruses

Preparing for better management of Tamiflu-resistant influenza viruses

Researchers in Umeå and Uppsala have found that residues of the influenza drug Tamiflu in our environment can make the influenza virus in birds resistant. This can have serious consequences in the event of an influenza pandemic. With more than 14 million SEK from the Swedish Research Councils Formas and VR, the research team will now continue their studies with a focus on alternative antiviral drugs. [More]