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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells. [More]
Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Glyphosate, often sold under the brand name of Roundup, is the world's most widely used weed-killer. While Glyphosate has approval from regulatory bodies worldwide, there are growing concerns about its possible adverse health effects. [More]
New UHPLC columns and solvents provide advanced separation power, speed of analysis

New UHPLC columns and solvents provide advanced separation power, speed of analysis

Researchers working with complex samples can now benefit from new UHPLC columns and solvents that are designed to provide advanced separation power, speed of analysis and throughput. [More]
Studies show mango consumption may contribute to protective health effects

Studies show mango consumption may contribute to protective health effects

Four new studies surrounding the effects of mango consumption suggest this superfruit has the potential to help combat adverse effects associated with high fat diets and obesity (animal study), as well inhibit growth of fat cells (anti-lipogenic properties in an in-vivo study), slow advancement of breast cancer tumors (animal study), as well as improve regularity and decrease inflammation associated with constipation (human subject study). [More]
University of Leicester-led study finds way to reverse symptoms of Parkinson’s and Alzheimer’s

University of Leicester-led study finds way to reverse symptoms of Parkinson’s and Alzheimer’s

A five-year study by an international team led from the University of Leicester has found a way of ‘reversing’ symptoms of neurodegenerative diseases such as Parkinson’s and Alzheimer’s – using fruit flies as test subjects. [More]
Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Bacteria-derived gut metabolites can affect brain’s myelin content and induce depression-like symptoms

Specific combinations of gut bacteria produce substances that affect myelin content and cause social avoidance behaviors in mice, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the medical journal eLife. This research suggests that targeting intestinal bacteria, or their metabolites, could be one way to treat debilitating psychiatric disorders and demyelinating diseases, like multiple sclerosis. [More]
Using proteomics to understand Alzheimer’s: an interview with Dr Renã Robinson

Using proteomics to understand Alzheimer’s: an interview with Dr Renã Robinson

In our bioanalytical mass spectrometry lab we use proteomics techniques to try to understand more about Alzheimer's disease. The primary thrust of our research is that we're interested in understanding the changes that take place outside of the brain and how those correlate with what's taking place inside the brain [More]
Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Adding CYP24A1 inhibitors may improve antitumor activity of vitamin D

Roswell Park Cancer Institute research on the most potent form of vitamin D, commonly called calcitriol, offers new insights into approaches that may enhance the antitumor activity of this much-studied human hormone. [More]
Psilocybin administration reduces reaction to social rejection in associated brain areas

Psilocybin administration reduces reaction to social rejection in associated brain areas

Social ties are vital for mental and physical health. However, psychiatric patients in particular frequently encounter social exclusion and rejection. Furthermore, psychiatric patients often react more strongly to social rejection than healthy persons and this can have negative consequences for the development and treatment of psychiatric disorders. [More]
MR may detect earliest Alzheimer's brain changes

MR may detect earliest Alzheimer's brain changes

Levels of the brain metabolite and neuroinflammation marker myo-inositol are elevated in asymptomatic patients with abnormal Alzheimer's disease (AD) biomarkers, say researchers. As repo ... [More]
High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

At the 57th Experimental Nuclear Magnetic Resonance Conference (www.enc-conference.org), Bruker is showcasing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the chemical and pharmaceutical industries. [More]
Daily walnut consumption positively impacts blood cholesterol levels in older adults

Daily walnut consumption positively impacts blood cholesterol levels in older adults

Initial findings from the Walnuts and Healthy Aging study presented at Experimental Biology 2016 (EB) indicate that daily walnut consumption positively impacts blood cholesterol levels without adverse effects on body weight among older adults. [More]
Altered metabolism of two essential amino acids helps drive development of glioblastoma

Altered metabolism of two essential amino acids helps drive development of glioblastoma

The altered metabolism of two essential amino acids helps drive the development of the most common and lethal form of brain cancer, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. [More]
YAP protein plays vital role in development of human neural crest

YAP protein plays vital role in development of human neural crest

The Hippo/YAP signalling pathway plays a crucial role when the cells of the neural crest - a structure that generates cell types such as bones and nerve tissue - specialise for a certain function in the human embryo and migrate to their target region within the body. [More]
Metabolite in gut microbiome could improve outcomes after bone marrow transplant

Metabolite in gut microbiome could improve outcomes after bone marrow transplant

Could playing better defense make bone marrow transplants more successful? With this question in mind, researchers began looking at whether the trillions of little bugs and bacteria living in our gastrointestinal tract could be the key to playing defense. [More]
WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University. [More]
Acute heart failure patients often have high levels of red meat metabolite

Acute heart failure patients often have high levels of red meat metabolite

Patients with acute heart failure often have high levels of the metabolite trimethylamine N-oxide (TMAO) - of which red meat is a major dietary source - according to researchers from the University of Leicester. [More]
Chronic low-dose exposure to organochlorine pesticides linked to future cognitive impairment

Chronic low-dose exposure to organochlorine pesticides linked to future cognitive impairment

Individuals subjected to chronic low-dose exposure to organochlorine pesticides show and increased risk to obtain a future diagnosis of cognitive impairment. This is shown in a study now published in Environmental International. [More]
Research findings identify potential genetics-guided precision medicine for leukemia patients

Research findings identify potential genetics-guided precision medicine for leukemia patients

An international research team has determined how inherited gene variations lead to severe drug toxicity that may threaten chances for a cure in children with leukemia. St. Jude Children's Research Hospital scientists led the study, results of which set the stage to expand the use of a patient's genetic make-up to tailor chemotherapy. [More]
Missouri S&T researcher comes up with patented breast cancer screening device

Missouri S&T researcher comes up with patented breast cancer screening device

Cancer screening could soon be as simple as giving a urine sample using a patented device developed by a Missouri University of Science and Technology researcher. This week, Wyoming-based Cancer.im Inc., a Viratech Corp. company and social network for cancer patients, survivors and caretakers, announced an agreement with Missouri S&T to commercialize the device. [More]
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