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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.
New study reports gymnastics equipment contains toxic flame-retardants linked to ADHD, cancer risks

New study reports gymnastics equipment contains toxic flame-retardants linked to ADHD, cancer risks

As the summer Olympics get underway, a new study co-authored by Boston University School of Public Health researchers reports that popular gymnastics training equipment contains mixtures of flame-retardant chemicals that have been linked to increased risks of ADHD, cancer and brain development delays. [More]
Retained metabolites may contribute to impaired cognitive function in kidney failure patients

Retained metabolites may contribute to impaired cognitive function in kidney failure patients

Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. [More]
New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

In biomedical research, working with tissue samples is indispensable because it permits insights into the biological reality of patients, for example, in addition to those gained from Petri dishes and computer simulations. [More]
Rare antibiotic compound detected in fungi for first time

Rare antibiotic compound detected in fungi for first time

Besides mushrooms such as truffles or morels, also many yeast and mould fungi, as well as other filamentous fungi belong to the Ascomycota phylum. They produce metabolic products which can act as natural antibiotics to combat bacteria and other pathogens. Penicillin, one of the oldest antibiotic agents, is probably the best known example. [More]
Food chemists find garlic aroma in breast milk of women who have consumed garlic

Food chemists find garlic aroma in breast milk of women who have consumed garlic

Food chemists at Friedrich-Alexander-Universität Erlangen-Nürnberg have found that garlic aroma is evident in the breast milk of women who have consumed garlic. [More]
Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies. [More]
Urolithin A found in pomegranates may improve muscle strength and endurance during aging

Urolithin A found in pomegranates may improve muscle strength and endurance during aging

Amazentis SA, an innovative life sciences company applying scientific breakthroughs in nutrition to manage health conditions linked to aging, announced today a collaborative publication in Nature Medicine with the École Polytechnique Fédérale de Lausanne, demonstrating that the Company's lead product candidate, urolithin A, improves mitochondrial and muscle function, resulting in enhanced muscle strength and endurance during aging. [More]
Researchers develop computer model for speed analysis of TB's complex life-cycle

Researchers develop computer model for speed analysis of TB's complex life-cycle

Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, is a serious global health problem accounting for 1.3 million worldwide deaths annually. [More]
Scientists insert metabolic pathway for carbon fixation and sugar production into E. coli bacterium

Scientists insert metabolic pathway for carbon fixation and sugar production into E. coli bacterium

All life on the planet relies, in one way or another, on a process called carbon fixation: the ability of plants, algae and certain bacteria to "pump" carbon dioxide (CO2) from the environment, add solar or other energy and turn it into the sugars that are the required starting point needed for life processes. [More]
New magnetically controlled drug safe, effective in dissolving blood clots

New magnetically controlled drug safe, effective in dissolving blood clots

Critical conditions associated with the blockage of blood vessels are one of the primary health concerns worldwide. [More]
Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

Tackling healthcare challenges in a changing world: an interview with Professor Jeremy Nicholson

As individuals and as populations our risks of getting diseases are determined partly genetically and partly from the environment that we live in. An important part of that environment that mediates between the outside world and the inside world of our bodies is the microbiome. [More]
NMR-based metabolomics: an interview with Prof. Claudio Luchinat

NMR-based metabolomics: an interview with Prof. Claudio Luchinat

We started from theoretical inorganic to bioinorganic chemistry, so looking at metals in proteins, enzymes and so on. About 30% of all the proteins that we have are metalloproteins, so it’s a huge contribution that inorganic chemistry is providing for life. [More]
Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

Metabolite of oral DMF drug for multiple sclerosis appears to slow onset of Parkinson's disease

The metabolite of a drug that is helping patients battle multiple sclerosis appears to significantly slow the onset of Parkinson's disease, researchers say. [More]
Analysing blood metabolites may help monitor effects of novel drugs

Analysing blood metabolites may help monitor effects of novel drugs

Testing for metabolic changes in the blood could indicate whether a cancer drug is working as designed, a new study reports. [More]
Gut microbe's metabolite butyrate hampers intestinal repair from IBD

Gut microbe's metabolite butyrate hampers intestinal repair from IBD

Intestinal stem cells are among the most rapidly dividing cells in the body, busily creating new cells to replace the ones that are constantly being sloughed off. But unlike stem cells elsewhere in the body, those in the intestine are hidden away, and for good reason, it turns out. [More]
NR supplements can reduce diabetes-related complications in mice

NR supplements can reduce diabetes-related complications in mice

A naturally occurring vitamin, nicotinamide riboside (NR), can lower blood sugar levels, reduce fatty liver, and prevent peripheral nerve damage in mouse models of prediabetes and type 2 diabetes (T2D), according to a new study by researchers at the University of Iowa and the Iowa City VA Health Care System. [More]
Accumulation of gut bacterial metabolite may lead to serious health problems in CKD patients

Accumulation of gut bacterial metabolite may lead to serious health problems in CKD patients

In patients with chronic kidney disease (CKD), the accumulation of a gut bacterial metabolite that's normally excreted in urine may contribute to serious health problems. The findings come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology. [More]
Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

Rice University researchers set stage for large-scale synthesis of cytotoxic agent to treat cancer

The lab of Rice University synthetic organic chemist K.C. Nicolaou has reported the streamlined total synthesis of delta12-prostaglandin J3, a molecule previously claimed to kill leukemic cancer cells. [More]
Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Study examines effects of ultra-low doses of glyphosate on gene expression profiles

Glyphosate, often sold under the brand name of Roundup, is the world's most widely used weed-killer. While Glyphosate has approval from regulatory bodies worldwide, there are growing concerns about its possible adverse health effects. [More]
New UHPLC columns and solvents provide advanced separation power, speed of analysis

New UHPLC columns and solvents provide advanced separation power, speed of analysis

Researchers working with complex samples can now benefit from new UHPLC columns and solvents that are designed to provide advanced separation power, speed of analysis and throughput. [More]
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