Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Vitamin D supplementation shows limited benefits for bone and heart health in hypertensive patients

Study evaluates the impact of vitamin D supplementation on bone health and cardiovascular risk factors in hypertensive patients, finding no significant improvements except in PTH levels, highlighting the complexity of vitamin D metabolism.

17 Mar 2024

CHOP study uncovers metabolic key to faster immune response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

15 Mar 2024

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

14 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

Optibrium launches a metabolism prediction software platform tailored to DMPK scientists

Semeta™ offers high sensitivity and superior precision for the prediction of Phase I and II metabolic routes, sites, products and liabilities in early drug discove.ry

From Optibrium Ltd. 27 Feb 2024

Gut microbial metabolite plays a role in exacerbating thrombosis

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.

23 Feb 2024

Study discovers link between a breakdown product from excess niacin and heart disease

Cleveland Clinic researchers have identified a new pathway that contributes to cardiovascular disease associated with high levels of niacin, a common B vitamin previously recommended to lower cholesterol.

19 Feb 2024

Study suggests high levels of vitamin B3 breakdown products are linked to higher risk of mortality, heart attacks, and stroke

Researchers utilized an untargeted metabolomics technique to look for new compounds and pathways that may contribute to residual cardiovascular disease risk.

19 Feb 2024

Healthy lifestyles linked to specific metabolic markers, large study finds

Researchers identify metabolomic markers linked to healthy lifestyles in a large study, showing a connection between lipid metabolism and reduced mortality risks.

18 Feb 2024

Oral bacteria interaction leads to smelly breath

Having bad breath really stinks! Now, researchers from Japan report that a particular combination of bacteria in our mouths may be responsible for producing some very unpleasant smells.

14 Feb 2024

Groundbreaking model predicts heart attack risk months in advance

Study introduces a novel biomarker-based model to predict imminent myocardial infarction (IMI), identifying key proteins and metabolites that could revolutionize early detection and prevention strategies.

14 Feb 2024

Microgreens: Superfoods for the future, packed with nutrients and easy to grow

Review in Heliyon highlights the nutritional superiority, cultivation methods, and health benefits of microgreens, emphasizing their potential as a sustainable functional food amidst global health and environmental challenges.

12 Feb 2024

Blueberries boost calmness but not cognition in metabolic syndrome study

A study in the American Journal of Clinical Nutrition finds that chronic blueberry intake does not significantly improve cognitive function, alertness, or mood in adults with metabolic syndrome, despite a slight improvement in picture recognition accuracy and self-rated calmness after a high-fat, high-sugar meal.

12 Feb 2024

Machine learning decodes data variations in metabolomics

A new study shows that it is possible to use machine learning and statistics to address a problem that has long hindered the field of metabolomics: large variations in the data collected at different sites.

12 Feb 2024

Associations between ultra-processed food consumption and phthalate exposures in pregnant women

Researchers explored the relationship between consuming ultra-processed foods and urinary phthalate concentrations during pregnancy.

12 Feb 2024

Pregnant women show significant immune system changes linked to gut microbiome

How gut microbiota and metabolite changes relate to immune function during pregnancy.

12 Feb 2024

Rucaparib and its major metabolite exhibit differential biological activity and synergy

Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion.

9 Feb 2024

Gut microbiota alterations may influence immune system changes during pregnancy

During pregnancy, a woman's immune system changes dramatically but researchers don't yet understand all the underlying mechanisms.

7 Feb 2024

New tool can help researchers to better understand the metabolism of microorganisms

Researchers from University of California San Diego, as part of a large collaboration with scientists around the world, have developed a new search tool to help researchers better understand the metabolism of microorganisms.

6 Feb 2024

Resveratrol can combat Alzheimer's via inflammatory suppression, study shows

Study demonstrates Resveratrol's ability to mitigate Alzheimer's Disease (AD) symptoms by inhibiting proinflammatory responses and promoting antioxidant enzyme expression in microglial cell lines, offering insights into its neuroprotective mechanisms.

5 Feb 2024

Metabolite News and Research

Further Reading

Vitamin D supplementation shows limited benefits for bone and heart health in hypertensive patients

CHOP study uncovers metabolic key to faster immune response

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Optibrium launches a metabolism prediction software platform tailored to DMPK scientists

Gut microbial metabolite plays a role in exacerbating thrombosis

Study discovers link between a breakdown product from excess niacin and heart disease

Study suggests high levels of vitamin B3 breakdown products are linked to higher risk of mortality, heart attacks, and stroke

Healthy lifestyles linked to specific metabolic markers, large study finds

Oral bacteria interaction leads to smelly breath

Groundbreaking model predicts heart attack risk months in advance

Microgreens: Superfoods for the future, packed with nutrients and easy to grow

Blueberries boost calmness but not cognition in metabolic syndrome study

Machine learning decodes data variations in metabolomics

Associations between ultra-processed food consumption and phthalate exposures in pregnant women

Pregnant women show significant immune system changes linked to gut microbiome

Rucaparib and its major metabolite exhibit differential biological activity and synergy

Gut microbiota alterations may influence immune system changes during pregnancy

New tool can help researchers to better understand the metabolism of microorganisms

Resveratrol can combat Alzheimer's via inflammatory suppression, study shows

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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