Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Macrophages stimulated to produce potent anti-inflammatory molecule

Researchers have discovered that macrophages, which play a key role in inflammation, also produce an anti-inflammatory molecule called itaconate.

29 Mar 2018

Realigning the brain clock to fit night shift patterns could result in better sleep, health

New research published in The Journal of Physiology shows that our brain clock can be shifted by light exposure, potentially to align it with night shift patterns.

28 Mar 2018

Cell-penetrating 'nanodrills' could be new platform for intracellular drug delivery

Researchers at Oregon State University and Oregon Health & Science University have created new nanomaterials able to cross cell membranes, establishing a novel platform for the intracellular delivery of molecular drugs and other cargo.

27 Mar 2018

Measurement of tumor's metabolic activity could help determine prostate cancer prognosis

A new approach to analyzing prostate gland tissue may help address a major challenge in treating prostate cancer - determining which tumors are unlikely to progress and which could be life threatening and require treatment.

27 Mar 2018

Fingerprint test accurately and noninvasively detects heroin, cocaine users

A fingerprint test published today in AACC's Clinical Chemistry journal can tell whether someone has taken heroin or cocaine, and accurately distinguishes between drug users versus individuals who were exposed to drug residue in the environment.

23 Mar 2018

New findings could have revolutionary impact on quality of life of older people

Researchers from UNSW and Harvard Medical School have discovered that replacing two naturally occurring molecules in the body could reverse symptoms of aging, potentially influencing how the body responds to and performs exercise.

22 Mar 2018

Research identifies new biomarkers for future dementia risk

Sudha Seshadri, M.D., founding director of the Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases at UT Health San Antonio, is co-leader and senior author on research announced March 6 that identifies novel biomarkers of risk for future dementia.

6 Mar 2018

Traces of caffeine and its byproducts in the blood can be indicative of Parkinson’s disease

Researchers at Juntendo University report in Neurology the potential use of blood levels of caffeine and its byproducts as biomarkers for Parkinson’s disease. The finding is promising for the development of a method enabling early identification of the disease.

16 Feb 2018

Study provides insight into mechanisms for increased male susceptibility to ASD

Exposure to androgens (male hormones) during brain development alters genes related to autism spectrum disorder (ASD), according to a new study published in Biological Psychiatry.

7 Feb 2018

Vitamin A-enriched cattle fodder is the key to protect against cow's milk allergy

A real milk allergy occurs in about three to five percent of European children and more rarely in adults. The disease is different from lactose intolerance, in which a lack of the enzyme lactase results in the inability to properly break down lactose, a sugar found in milk products.

6 Feb 2018

Compounds derived from hops may improve cognitive, other functions in metabolic syndrome patients

A group of compounds derived from hops can likely improve cognitive and other functions in people with metabolic syndrome, new research at Oregon State University and Oregon Health & Science University suggests.

5 Feb 2018

Researchers block common siren call of glioblastoma and metastatic breast cancer

Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive.

23 Jan 2018

The Salk Institute and Indivumed collaborate for cutting-edge cancer research

The Salk Institute, which hosts a National Cancer Institute-designated cancer center and Indivumed GmbH, a world leading cancer research company today announce a multi-year strategic alliance to secure, preserve and analyze human cancer tissue and annotated clinical data from consenting patients around the world, enabling the most cutting-edge basic and translational research in cancer.

16 Jan 2018

Exposure to estrogen-mimicking compounds may reverse effects of breast cancer treatment

Scientists from The Scripps Research Institute have discovered that two estrogen-mimicking compounds found in many foods appear to potently reverse the effects of palbociclib/letrozole, a popular drug combination for treating breast cancer.

12 Jan 2018

Soil-dwelling bacterium produces potential weapon against melanoma

A type of soil-dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows.

4 Jan 2018

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Our immune system protects our bodies from numerous pathogenic microbes and toxins in the environment. The system comprises innate (non-specific) and adaptive (acquired) immunity.

26 Dec 2017

Ludwig study elucidates mechanism behind metabolic vulnerability of some breast tumors

Scientists have known since the 1980s that many cancer cells are relatively sensitive to the deprivation of an essential amino acid known as methionine. It has, however, long been unclear what causes such marked dependency on methionine.

20 Dec 2017

Novel compound inhibits mycomembrane biosynthesis and kills tuberculosis bacteria

Tuberculosis is one of the most widespread life-threatening infectious diseases. Not only does antibiotic resistance make treatment increasingly difficult, but the bacteria’s relatively impermeable mycomembrane also limits the effectiveness of many drugs.

12 Dec 2017

Taurine could boost effectiveness of existing multiple sclerosis therapies

New research suggests that administering taurine, a molecule naturally produced by human cells, could boost the effectiveness of current multiple sclerosis (MS) therapies.

8 Dec 2017

Researchers find low levels of neuroactive steroid in both obese and anorexic women

Women at opposite extremes of the weight spectrum have low levels of the neuroactive steroid allopregnanolone, according to new research published in the journal Neuropsychopharmacology.

10 Nov 2017