Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

New lab-on-a-chip system can detect effects of toxic substances on hemoglobin in blood

A new lab-on-a-chip system, developed by the University of Twente in The Netherlands, is capable of fast analysis of the effects of toxic substances on hemoglobin, for example. It mimicks human metabolism.

4 Oct 2016

Unknown exposure to second-hand smoke linked to increased mortality in non-smokers

A new biomarker has identified known and unknown exposure to second-hand smoke and confirmed a strong association to increased mortality in non-smokers, according to a new study from the Icahn School of Medicine at Mount Sinai.

26 Sep 2016

Maternal serum levels of nicotinamide linked to child’s risk of atopic eczema

Infants whose mothers had a higher level of a particular type of vitamin B during pregnancy have a lower risk of eczema at age 12 months, new Southampton research has shown.

23 Sep 2016

Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways.

14 Sep 2016

Researchers describe how genetic mutations cause unnamed neurological disorder

In rare cases -- for instance, among siblings in two families from Pakistan and Oman described in a new study -- children have been born with an unnamed neurological disorder.

6 Sep 2016

ToMMo scientists identify genetic variants affecting enzymatic activities in healthy people

Scientists from Tohoku University's Tohoku Medical Megabank Organization have published research about genetic diversity and metabolome in Scientific Reports.

1 Sep 2016

Whitehead Institute scientists develop novel method for profiling mitochondrial metabolites

Whitehead Institute scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within the cellular organelles known as mitochondria, often referred to as the "powerhouses of the cell."

31 Aug 2016

CFS possesses objectively identifiable chemical signature in men and women, study reveals

Dauer is the German word for persistence or long-lived. It is a type of stasis in the development in some invertebrates that is prompted by harsh environmental conditions. The findings are published online in the August 29 issue of PNAS.

29 Aug 2016

Research finds differences in breast milk of women who gave birth to pre-term infants

About 7 percent of all Danish children are born prematurely. This is of significant im-portance not only to the child's development, but it also affects the mother's body that - unexpectedly - has to produce the necessary nutrition for the newborn baby.

9 Aug 2016

Research shows alcohol abuse drug inhibits ocular conjunctival scarring in mouse model

New research from University College London, Moorfields Eye Hospital and Duke University School of Medicine has identified a gene that drives scarring, together with a rapidly translatable therapy, for the UK's most common cause of blinding conjunctivitis.

4 Aug 2016

Studies highlight key role for vitamin A metabolite retinoic acid in ocular fibrosis

Mucous membrane pemphigoid is an autoimmune disease that causes inflammation and scarring in mucosal tissues. Affected individuals frequently exhibit scarring in the eye, which can lead to blindness in as many as 20% of patients.

4 Aug 2016

Single drink of nutritional ketone can alter metabolism to improve performance of cyclists

A drink developed for soldiers to generate energy from ketones rather than carbs or fat allowed highly trained cyclists to add up to 400 meters of distance to their workouts, a UK-led study reports July 27 in Cell Metabolism.

27 Jul 2016

New study reports gymnastics equipment contains toxic flame-retardants linked to ADHD, cancer risks

As the summer Olympics get underway, a new study co-authored by Boston University School of Public Health researchers reports that popular gymnastics training equipment contains mixtures of flame-retardant chemicals that have been linked to increased risks of ADHD, cancer and brain development delays.

26 Jul 2016

Retained metabolites may contribute to impaired cognitive function in kidney failure patients

Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jul 2016

New mass spectrometry imaging protocol allows analysis of metabolite composition of tissues

In biomedical research, working with tissue samples is indispensable because it permits insights into the biological reality of patients, for example, in addition to those gained from Petri dishes and computer simulations.

18 Jul 2016

Rare antibiotic compound detected in fungi for first time

Besides mushrooms such as truffles or morels, also many yeast and mould fungi, as well as other filamentous fungi belong to the Ascomycota phylum. They produce metabolic products which can act as natural antibiotics to combat bacteria and other pathogens. Penicillin, one of the oldest antibiotic agents, is probably the best known example.

18 Jul 2016

Food chemists find garlic aroma in breast milk of women who have consumed garlic

Food chemists at Friedrich-Alexander-Universität Erlangen-Nürnberg have found that garlic aroma is evident in the breast milk of women who have consumed garlic.

15 Jul 2016

Leukemia drug increases brain dopamine, lowers toxic proteins linked to Parkinson's or dementia

A small phase I study provides molecular evidence that an FDA-approved drug for leukemia significantly increased brain dopamine and reduced toxic proteins linked to disease progression in patients with Parkinson's disease or dementia with Lewy bodies.

12 Jul 2016

Urolithin A found in pomegranates may improve muscle strength and endurance during aging

Amazentis SA, an innovative life sciences company applying scientific breakthroughs in nutrition to manage health conditions linked to aging, announced today a collaborative publication in Nature Medicine with the École Polytechnique Fédérale de Lausanne, demonstrating that the Company's lead product candidate, urolithin A, improves mitochondrial and muscle function, resulting in enhanced muscle strength and endurance during aging.

11 Jul 2016

Researchers develop computer model for speed analysis of TB's complex life-cycle

Tuberculosis (TB), caused by the pathogen Mycobacterium tuberculosis, is a serious global health problem accounting for 1.3 million worldwide deaths annually.

1 Jul 2016