Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling

Using a combination of enzyme activity and metabolite profiling, we determined that this protein-whose function was previously unknown-serves as a key regulator of a lipid signaling network that contributes to cancer," said Benjamin F. Cravatt, a Scripps Research professor and a member of its Skaggs Institute for Chemical Biology who led the study.

20 Oct 2006

$74 million allocated to study environmental causes of disease

As part of the new Exposure Biology Program, the National Institute of Environmental Health Sciences, a component of the National Institutes of Health, today announced $74 million in grant opportunities for the development of new technologies that will improve the measurement of environmental exposures that contribute to human disease.

19 Oct 2006

Progesterone improves outcomes for victims of traumatic brain injury

A new study suggests that giving progesterone to victims with Traumatic Brain Injury (TBI) shortly following brain injury may reduce the risk of death and the degree of disability, and appears to be safe.

3 Oct 2006

Licensing arrangement reached for antiepileptic drug developed at Hebrew University

A worldwide licensing arrangement for development, production and marketing of an antiepileptic drug created at the Hebrew University of Jerusalem has been signed by Shire Pharmaceuticals with Yissum, the Hebrew University's technology transfer company.

5 Sep 2006

Dual-mode nanoscale imaging yields new details of cellular events

To create drugs capable of targeting malignancies, scientists must first decode exactly how a cell or a group of cells communicates with other cells and reacts to a broad spectrum of complex biomolecules surrounding it.

21 Aug 2006

Fatty acids found in dairy products shown to treat diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State.

3 Aug 2006

Estradiol and its metabolites and their association with knee osteoarthritis

Osteoarthritis, which usually develops between the ages of 40 and 50, is more prevalent in women. It is thought that sex hormones may play a role in developing the disease, since they can be involved in inflammation of the tissues affected by it.

26 Jul 2006

Calcium and vitamin D supplements do not reduce breast cancer

A large multicenter randomized clinical trial reported that supplementation with calcium and vitamin D did not reduce breast cancer risk in the overall population.

7 Jun 2006

Cancer-causing chemicals associated with tobacco smoke found in the urine of nearly half the babies of smoking parents

When mum or dad puffs on a cigarette, their infants may inhale the resulting second-hand smoke. Now, scientists have detected cancer-causing chemicals associated with tobacco smoke in the urine of nearly half the babies of smoking parents.

12 May 2006

New method could predict individual patient responses to drug treatments

Scientists from Imperial College London and Pfizer have developed a new method that could predict individual patient responses to drug treatments. The authors anticipate that the development will advance biomedical research further towards development of personalised medicines.

28 Apr 2006

Novel and important benefits of vitamin D and the problems associated with vitamin D deficiency

...will be discussed at the American Association of Clinical Endocrinologists (AACE) Fifteenth Annual Meeting and Clinical Congress, April 26-30, at the Hyatt Regency Chicago.

19 Apr 2006

Device for testing breath for the presence of metabolites associated with breast cancer

One of the biggest problems in fighting breast cancer is the lack of inexpensive, early detection diagnostic tools.

7 Apr 2006

Discovery of a new mechanism for the neurodegenerative effects of amphetamines

University of Toronto study finds amphetamines are converted in the brain into free radicals whose effects manifest and linger long after the amphetamine has left the body.

7 Apr 2006

More than a billion may suffer from vitamin D deficiency

More than a billion may suffer from vitamin D deficiency. Consequences may be more severe than thought. Prominent clinician calls for action.

6 Apr 2006

Inflammation cuts both ways

Inflammation cuts both ways. When invaded by an infectious agent, for example, the body calls on the forces of inflammation to fight and defeat the intruder.

6 Apr 2006

PR Pharmaceuticals issued U.S. patent covering 2-methoxyestradiol for the treatment of diabetes

The patent which is assigned to the University of Pittsburgh has been exclusively licensed to PRP. The drug, known as PulmoLAR, containing 2ME as active ingredient, is currently developed by PRP for the treatment of pulmonary arterial hypertension (PAH).

21 Mar 2006

Smoking interferes with the brain's ability to recover from the effects of chronic alcohol abuse

"This study suggests that for better brain recovery, it may be beneficial for alcoholics in early abstinence to stop smoking as well," concludes Dieter Meyerhoff, Dr.rer.nat., a radiology researcher at SFVAMC and the senior author of the study. Meyerhoff is also a professor of radiology at the University of California, San Francisco.

19 Mar 2006

Effects of prenatal exposure to pesticides

Children in Ecuador whose mothers were exposed to pesticides while pregnant had increased blood pressure and diminished ability to copy geometric figures as compared to a control group, according to an epidemiological study in the March issue of Pediatrics.

9 Mar 2006