Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Organic diets lower children's exposure to pesticides

Organic diets lower children's dietary exposure to two common pesticides used in U.S. agricultural production, according to a study by Emory University researcher Chensheng "Alex" Lu, PhD. The substitution of organic food items for children's normal diets substantially decreased the pesticide concentration to non-detectable levels.

19 Feb 2006

Racial and ethnic differences in nicotine metabolism exist among adolescent smokers

New research by scientists with the National Institute on Drug Abuse (NIDA), National Institutes of Health, suggests that some of the racial and ethnic differences underlying how adults' bodies metabolize nicotine also are at work during adolescence.

23 Jan 2006

New method to find new metabolites

Ever since penicillin, a byproduct of a fungal mold, was discovered in 1929, scientists have scrutinized fungi for other breakthrough drugs. As reported Jan. 20 in the Journal of Chemistry and Biology, a team led by a University of Wisconsin-Madison researcher has developed a new method that may speed the ongoing quest for medically useful compounds in fungi.

23 Jan 2006

University of Michigan Medical School to study the science of obesity and metabolism

As millions of Americans prepare their New Year’s resolutions to lose weight, eat better or exercise more, the University of Michigan Medical School is launching a new center that may help explain why so many resolutions fail, while others succeed.

29 Dec 2005

Synthetic compound could arrest development of Alzheimer's

Spanish chemists have developed a promising set of synthetic compounds that one day could help slow or perhaps halt the progression of Alzheimer's disease and other neurological disorders.

21 Dec 2005

Common gene variation lessens Tamoxifen’s benefit

Researchers have discovered that one of the most commonly prescribed drugs for breast cancer, tamoxifen, may not be as effective for women who inherit a common genetic variation.

19 Dec 2005

Tryptophan metabolites play an important role in the immune system

Tryptophan is the source of Thanksgiving legend and grist for a "Seinfeld" episode, but it's not the chemical that you'd expect to find in Lawrence Steinman's lab.

7 Nov 2005

Calcitriol - promising chemopreventive agent that may prevent prostate cancer

The active metabolite of vitamin D, calcitriol, and other vitamin D analogs are promising chemopreventive agents that may prevent prostate cancer, according to a study presented today at the American Association for Cancer Research's 4th annual Frontiers in Cancer Prevention Research meeting in Baltimore.

3 Nov 2005

DOS47 scientific paper published in the Journal of Experimental Therapeutics and Oncology

Helix BioPharma announced today the publication of a scientific paper in the Journal of Experimental Therapeutics and Oncology (volume 5, number 2, pp. 93-99), entitled "Urease-induced alkalinization of extracellular pH and its antitumour activity in human breast and lung cancers."

25 Oct 2005

Researchers look at pharmacogenomics

When patients receive chemotherapy, 15 percent will have severe side effects while 85 percent will not - even though they're given the same relative dose.

28 Sep 2005

Flavanols help smokers repair blood vessel function

Phytochemicals known as flavanols, which are found in chocolate, fruits and vegetables, can boost the levels of nitric oxide in the blood of smokers and reverse some of their smoking-related impairment in blood vessel function, according to a new study in the Oct. 4, 2005, issue of the Journal of the American College of Cardiology.

28 Sep 2005

Substance found in cotton plant could help treat psoriasis

A substance found in the cotton plant could help treat the common skin disease psoriasis, according to new research from the Pharmacy School at Sunderland University launched at the British Pharmaceutical Conference in Manchester.

28 Sep 2005

Phytoestrogens linked with a lower lung cancer risk

A diet higher in plant-derived compounds known as phytoestrogens is linked with a lower lung cancer risk, according to a study in the current issue of Journal of the American Medical Association (JAMA).

27 Sep 2005

Salicylate an active metabolite of aspirin - weakens lipid membranes

It's well known that high doses of aspirin can cause ulcers and temporary deafness, but the biochemical mechanism responsible for these phenomena has never been deciphered.

19 Sep 2005

Fine-tuning fertility testing with take-home technology

A take-home fertility-testing kit under development in a Massey University laboratory will give women and couples further control over pregnancy planning.

6 Sep 2005

IP 751 a marijuana-derived drug effectively suppresses pain and bladder overactivity in hypersensitive bladder disorders

IP 751, a potent synthetic analog of a metabolite of THC-the principal active ingredient of marijuana-effectively suppresses pain and bladder overactivity in hypersensitive bladder disorders such as interstitial cystitis (IC), according to animal model study results presented today at the annual meeting of the International Continence Society.

1 Sep 2005

Mushrooms are a great source of antioxidants

Using a new, more sensitive-testing approach they developed for fungi, Penn State food scientists have found that mushrooms are a better natural source of the antioxidant ergothioneine than either of the two dietary sources previously believed to be best

31 Aug 2005

Nationwide survey reports a high rate of concern about body image in both boys and girls

A nationwide survey of more than 10,000 adolescents, published in the August issue of Pediatrics, reports a high rate of concern about body image in both boys and girls, and finds that adolescents with such concerns are much more likely to use hormones and dietary supplements to enhance their physique.

1 Aug 2005

Potatoes found to help reduce blood pressure and other diseases

UK scientists have identified bioactive plant chemicals in the most practical of staple foods, the potato. These natural chemicals have been associated with reduced blood pressure and they selectively affect a chemotherapeutic target for trypanosomes and similar diseases such as sleeping sickness.

30 Jun 2005

New drug candidate against HIV-infection

As a part of a research collaboration, scientists at the Sahlgrenska Academy at Gotenborg University, Sweden, have developed a new drug candidate against HIV-infection. The new substance, named alphaHGA, will be tested on patients this year.

30 Jun 2005