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Researchers use residues in wastewater to study illicit drug consumption

At the start of the COVID-19 pandemic, stay-at-home orders and other restrictions drastically affected how people lived and worked, resulting in social isolation and economic instability. Now, researchers show that some people turned to a variety of drugs for relief. Using wastewater analysis, the team identified a spike in consumption of easily abused prescription opioids and anti-anxiety sedatives, while some illicit drug use plummeted, between March and June 2020.

23 Aug 2021

Study: Any form of exercise may not be the most effective prognostic tool for heart failure patients

While exercise therapy for heart failure (HF) patients with low heart function has been shown to be an effective prognostic tool, the level and format of exercise that yields optimal effects is still unclear.

19 Aug 2021

WVU researcher investigates inflammatory responses produced by exposure to chemical agents

Many of us face safety risks at work, but those serving in the military or working in law enforcement and industrial settings are at greater risk for dangerous chemical exposures.

18 Aug 2021

COVIDome Explorer online portal launched to accelerate COVID-19 research on a global scale

To further accelerate COVID-19 research on a global scale, investigators from the University of Colorado Anschutz Medical Campus have created a multidimensional dataset, known as the COVIDome dataset, derived from hospitalized COVID-19 patients versus negative controls.

17 Aug 2021

Bioengineers develop implantable piezoelectric therapeutic devices

Bioengineers have developed biocompatible generators that create electrical pulses when compressed by body motions.

16 Aug 2021

Researchers aim to identify gene-lifestyle interactions that contribute to cardiometabolic disease risk

Researchers at Washington University School of Medicine in St. Louis have received a four-year, $8.8 million grant to ramp up research aimed at unraveling how an individual's risks of cardiometabolic diseases, such as heart disease and Type 2 diabetes, are influenced by the interaction of specific genes with demographic and lifestyle factors.

11 Aug 2021

Hypoxic inflammation leads to inefficient cardiac repair after heart attacks

Activation of hypoxia inducible factors (green) in macrophages (purple) that have infiltrated damaged cardiac tissue (right) in heart tissue.

10 Aug 2021

UAB researchers identify potential therapeutic target for ovarian cancer

A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers say in a study published in the journal Oncogenesis.

5 Aug 2021

Study looks at potent phytocompounds from Himalayan herbs to treat COVID-19

Considering the antiviral activity of medicinal herbs, a new study published in the journal Current Pharmacology Reports focuses on the identification of potent phytochemicals from Himalayan herbs, namely, Rheum emodi, Thymus serpyllum, and Artemisia annua, for the treatment of COVID-19.

1 Aug 2021

Two new proteins identified as therapeutic targets for preventing NAFLD and associated liver cancer

An international study led by the Lipids&Liver research team at the UPV/EHU-University of the Basque Country, the results of which have recently been published in the prestigious journal Cancer Research, has demonstrated that inhibiting either of the proteins E2F1 or E2F2 in the liver protects against the development of obesity-driven nonalcoholic fatty liver disease and its progression to cancer.

29 Jul 2021

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

Scientists from the UK have recently identified an antiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine as a potential serum biomarker to diagnose active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the medRxiv* preprint server while awaiting peer review.

27 Jul 2021

New blood test could help predict the severity of COVID-19 symptoms

During the height of the pandemic, some hospitals were overwhelmed with patients seeking treatment for COVID-19.

22 Jul 2021

Study: Second dose of COVID-19 vaccine induces a powerful boost to the immune system

The second dose of a COVID-19 vaccine induces a powerful boost to a part of the immune system that provides broad antiviral protection, according to a study led by investigators at the Stanford University School of Medicine.

19 Jul 2021

Researchers discover major metabolite involved in regulating intestinal bacteria

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria.

19 Jul 2021

New method shows how fatty acids are absorbed by single cells

A new method developed by Institute for Systems Biology and University of California, Riverside provides new insights into cancer biology by allowing researchers to show how fatty acids are absorbed by single cells.

16 Jul 2021

UH researchers report new gut–liver drug recycling process

A team of University of Houston pharmaceutical researchers is reporting a newly recognized process of drug metabolism in the intestines - followed by recycling through the liver - that could have important implications for developing treatments for intestinal diseases and for taking multiple medications at the same time.

14 Jul 2021

Metabolomics: The Individual Metabolic Profile is the Key to Personalized Medicine

The study of these unique substances in each of us paves the way for a revolution in the treatment and prevention of diseases, allowing for early diagnosis and increasingly targeted pharmacological treatments.

From Bruker BioSpin - NMR, EPR and Imaging 14 Jul 2021

Bacteroides-dominant gut microbiome linked with advanced cognition and language skills in infant boys

The University of Alberta-led research followed more than 400 infants from the CHILD Cohort Study (CHILD) at its Edmonton site. Boys with a gut bacterial composition that was high in the bacteria Bacteroidetes at one year of age were found to have more advanced cognition and language skills one year later. The finding was specific to male children.

13 Jul 2021

Gene therapy shows promise in children with devastating genetic disorder

Children with a devastating genetic disorder characterized by severe motor disability and developmental delay have experienced sometimes dramatic improvements in a gene therapy trial launched at UCSF Benioff Children's Hospitals.

12 Jul 2021

Metabolites of intestinal bacteria can positively influence the efficacy of tumor therapies

Certain metabolites of bacteria from the intestine make immune cells more aggressive as a new study conducted by scientists from Würzburg and Marburg reveals. The findings could help improve cancer therapies.

9 Jul 2021