Metabolites News and Research

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Study identifies metabolic processes associated with multiple, unrelated diseases

Many older, but also increasingly younger, people suffer from several diseases at the same time. Scientists at the Berlin Institute of Health at Charité – Universitätsmedizin Berlin, together with colleagues from Munich and the United Kingdom, have now identified common risk factors that predispose to multiple even seemingly unrelated diseases.

22 Mar 2021

Male fertility and androgen production may be impacted by COVID-19

An interesting new study has appeared online in the journal Hormones that discusses the effects of COVID-19 on the male and female gonads.

22 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Researchers unravel how a novel microbial small molecule is connected to dental caries development

An inter-disciplinary team of researchers led by Prof. Qian Peiyuan, Chair Professor at the Hong Kong University of Science and Technology's Department of Ocean Science and Division of Life Science has unraveled how a novel microbial small molecule released by Streptococcus mutans (S. mutans) - a bacterium commonly found in the human oral cavity - is connected to dental caries development using a synthetic biology approach, offering new insights to the health impact of the human oral microbiota and facilitating future research on the prevention of tooth decay.

16 Mar 2021

Ketogenesis has a protective effect on mitochondria, finds study

Ketone bodies are generally an alternative energy source during starvation, but in newborns, ketogenesis is active regardless of nutritional status. In a recent study from Kumamoto University (Japan), researchers analyzed the effects of ketogenesis in mice and found that it has a protective effect on cells by maintaining the function of mitochondria.

16 Mar 2021

Engineered mouse Intestine Chip platform can help study host-microbiome interactions

Trillions of commensal microbes live on the mucosal and epidermal surfaces of the body and it is firmly established that this microbiome affects its host's tolerance and sensitivity of the host to a variety of pathogens.

16 Mar 2021

Discover, Visualize and Identify Biomarkers

In this interview, Lucy Woods from Bruker Daltonics talks to News-Medical Life Sciences about the new MetaboScape to help identify and discover more biomarkers.

From Bruker Life Sciences Mass Spectrometry 10 Mar 2021

Scientific statement defines the distinctive features of opioid-associated cardiac arrest

Out-of-hospital cardiac arrests triggered by opioid overdose are a significant cause of death among adults 25 to 64, according to a scientific statement from the American Heart Association, the nation's largest voluntary health organization focused on heart and brain health for all.

8 Mar 2021

Pancreatitis drug blocks SARS-CoV-2 activators in the upper respiratory tract

Pancreatitis drug Camostat inhibits new SARS-CoV-2 activators identified in the upper respiratory tract. There are no therapeutics available that have been developed for COVID-19 treatment.

5 Mar 2021

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

A team of scientists from Sweden and India has recently characterized the host cell metabolic alterations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Their findings reveal that SARS-CoV-2 modulates the host cell's central carbon metabolism to facilitate replication and infection propagation.

28 Feb 2021

FDA approves Nulibry to reduce risk of death caused by rare genetic, metabolic disorder

Today, the U.S. Food and Drug Administration approved Nulibry (fosdenopterin) for injection to reduce the risk of death due to Molybdenum Cofactor Deficiency Type A, a rare, genetic, metabolic disorder that typically presents in the first few days of life, causing intractable seizures, brain injury and death.

27 Feb 2021

Immunologists map unknown biological machinery to produce memory T cells

Immunologists at St. Jude Children's Research Hospital have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses and tumor cells.

26 Feb 2021

Study provides better understanding of metabolic routes involved in regulating satiety

Results of the European study SATIN (SATiety INnovation) reveal a relation between certain metabolites in the blood and the satiety perceived after consuming food.

22 Feb 2021

Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology

NewsMed interviews Michelle Peace on her Pittcon presentation entitled, "Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology".

From Pittcon 15 Feb 2021

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma.

13 Feb 2021

Metabolomics and machine learning used to identify possible COVID-19 biomarkers

One of the many mysteries still surrounding COVID-19 is why some people experience only mild, flu-like symptoms, whereas others suffer life-threatening respiratory problems, vascular dysfunction and tissue damage.

10 Feb 2021

Modified lipids target the body’s endocannabinoid system to regulate pain and inflammation

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, researchers report.

10 Feb 2021

BMI, male sex, smoking, depression and metabolic syndrome contribute to biological aging

A 'biological age' score predicts that being male, overweight, a smoker and having depression all contribute to biological aging, a study published today in eLife reports.

9 Feb 2021

Metal-containing radiopharmaceuticals could improve access to diagnostic imaging of AD

A team of researchers from the Laboratory of Biophysics at NUST MISIS, Lomonosov Moscow State University and D. Mendeleev University of Chemical Technology of Russia has summarized metal-containing diagnostic agents for positron emission tomography (PET), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT) imaging of Alzheimer's disease (AD).

9 Feb 2021

Challenges of Cannabis Analysis and Impacts on Driving and Public Health

An interview with Madeleine Swortwood of Sam Houston State University, on the symposia she will give at Pittcon 2022 about the analytical challenges of cannabis and its impacts on driving and public health.

From Pittcon 9 Feb 2021

Metabolites News and Research

Study identifies metabolic processes associated with multiple, unrelated diseases

Male fertility and androgen production may be impacted by COVID-19

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Researchers unravel how a novel microbial small molecule is connected to dental caries development

Ketogenesis has a protective effect on mitochondria, finds study

Engineered mouse Intestine Chip platform can help study host-microbiome interactions

Discover, Visualize and Identify Biomarkers

Scientific statement defines the distinctive features of opioid-associated cardiac arrest

Pancreatitis drug blocks SARS-CoV-2 activators in the upper respiratory tract

SARS-CoV-2 modulates host cell central carbon metabolism for reproduction

FDA approves Nulibry to reduce risk of death caused by rare genetic, metabolic disorder

Immunologists map unknown biological machinery to produce memory T cells

Study provides better understanding of metabolic routes involved in regulating satiety

Innovations in Forensic Examination of Seized Drugs and Forensic Toxicology

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Metabolomics and machine learning used to identify possible COVID-19 biomarkers

Modified lipids target the body’s endocannabinoid system to regulate pain and inflammation

BMI, male sex, smoking, depression and metabolic syndrome contribute to biological aging

Metal-containing radiopharmaceuticals could improve access to diagnostic imaging of AD

Challenges of Cannabis Analysis and Impacts on Driving and Public Health

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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