Metastasis News and Research RSS Feed - Metastasis News and Research

Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases
Novel mechanism can suppress blood vessel leakage, reduce tumour spread in mice

Novel mechanism can suppress blood vessel leakage, reduce tumour spread in mice

Cancer therapy is often hampered by the accumulation of fluids in and around the tumour, which is caused by leakage from the blood vessels in the tumour. Researchers at Uppsala University now show how leakage from blood vessels is regulated. [More]
Research shows tumor suppressor protein regulates polarity genes

Research shows tumor suppressor protein regulates polarity genes

What does Brad Pitt have in common with a fruit fly? His Hollywood hairstyles cover a prominent cowlick - the swirl of hair that that is caused by a patterning mechanism also active in our two-winged friends -- that similarly feature "polarized" hair patterns. [More]
Scientists provide overview of most promising compounds to combat prostate cancer

Scientists provide overview of most promising compounds to combat prostate cancer

Scientists from MIPT (Moscow Institute of Physics and Technology), MSU (Moscow State University), and National University of Science and Technology “MISIS” provided an overview of the most promising compounds which can be used as medications for prostate cancer. [More]
Targeted therapies suppress T cell activity that could actually help fight tumors

Targeted therapies suppress T cell activity that could actually help fight tumors

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations. [More]
Increased travel distance to cancer treatment facility affects receipt of RT

Increased travel distance to cancer treatment facility affects receipt of RT

Increased travel distance to a cancer treatment facility negatively impacts the likelihood that patients with stage II/III rectal cancer will receive radiation therapy (RT) to treat their disease, according to a study analyzing 26,845 patient records from the National Cancer Data Base that was published in the March 2016 issue of International Journal of Radiation Oncology • Biology • Physics, the official scientific journal of the American Society for Radiation Oncology . [More]
Key molecule in breast, lung cancer cells can help prevent spread of cancer

Key molecule in breast, lung cancer cells can help prevent spread of cancer

Scientists have revealed that a key molecule in breast and lung cancer cells can help switch off the cancers' ability to spread around the body. [More]
Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation. [More]
Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

Neo-Bioscore staging system adds HER2 status for precise prognostic stratification of breast cancer subtypes

A new breast cancer staging system developed by researchers at The University of Texas MD Anderson Cancer Center finds that incorporating tumor biology is a critical prognostic indicator for women who undergo neoadjuvant, or pre-surgical, therapy for breast cancer. [More]
Molecular basis for tongue cancer progression: an interview with Dr Simona Principe

Molecular basis for tongue cancer progression: an interview with Dr Simona Principe

Head and neck cancers (HNC) are the sixth most common cancers worldwide, with approximately 600,000 new cases diagnosed every year. [More]
Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists develop antibody to curb lung tumor cell growth, breast cancer metastasis

Johns Hopkins scientists report they have developed an antibody against a specific cellular gateway that suppresses lung tumor cell growth and breast cancer metastasis in transplanted tumor experiments in mice, according to a new study published in the February issue of Nature Communications. [More]
Blocking Mena protein could help prevent cancer metastasis, says MIT researcher

Blocking Mena protein could help prevent cancer metastasis, says MIT researcher

A new study from MIT reveals how cancer cells take some of their first steps away from their original tumor sites. This spread, known as metastasis, is responsible for 90 percent of cancer deaths. [More]
Prognostic test could help lower cancer recurrence for colorectal patients

Prognostic test could help lower cancer recurrence for colorectal patients

Colorectal cancer, one of the most commonly diagnosed cancers in the United States, is not a commonly discussed disease. Often symptomless in early stages, the cancer is more difficult to treat as it progresses, requiring chemotherapy in later stages. Researchers at the University of Notre Dame are working on a way to identify patients who would benefit from chemotherapy before the cancer progresses. [More]
Combination drug therapy may stop KRAS-mediated lung adenocarcinoma

Combination drug therapy may stop KRAS-mediated lung adenocarcinoma

Researchers on Mayo Clinic's Florida campus have shut down one of the most common and lethal forms of lung cancer by combining the rheumatoid arthritis drug auranofin with an experimental targeted agent. [More]
Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Combining photoimmunotherapy and gene transduction effective against elusive gastric cancer cells

Researchers report photoimmunotherapy to be effective against elusive gastric cancer cells following transduction with the gene that expresses the extracellular domain protein of HER2. The results are published in the journal Small Molecule Therapeutics in February 2016. [More]
Breast cancer can be more aggressive in obese people

Breast cancer can be more aggressive in obese people

An international team of researchers, with the participation of the University of Granada, has revealed new data on why breast cancer has a higher incidence and is more aggressive in obese people. The reason is that peritumoral fat (the fat around the tumor) facilitates the expansion and invasion of cancer stem cells (CSCs), which are responsible of the onset and growth of the tumor. [More]
Researchers reveal how butterfly disease patients develop cutaneous squamous cell carcinomas

Researchers reveal how butterfly disease patients develop cutaneous squamous cell carcinomas

Fragile skin that blisters easily: 90 percent of the patients that suffer from the skin condition recessive dystrophic epidermolysis bullosa (RDEB) develop rapidly progressing cutaneous squamous cell carcinomas, a type of skin cancer, by the age of 55. 80 percent of these patients will die due to metastasis within five years after the cancer has been first detected. [More]
CWRU researcher to customize tobacco mosaic virus to treat human cancers

CWRU researcher to customize tobacco mosaic virus to treat human cancers

A Case Western Reserve University researcher has been awarded more than $3 million in federal and foundation grants to turn common plant viruses into cancer sleuths and search-and-destroy emissaries. [More]
Study provides critical insight into Warburg effect

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers. [More]
Beta blockers may improve effectiveness of triple negative breast cancer treatments

Beta blockers may improve effectiveness of triple negative breast cancer treatments

New research published in the March 2016 issue of The FASEB Journal, shows that a commonly prescribed class of high blood pressure drugs may have the potential to slow the growth of triple negative breast cancer tumors. These drugs, called "beta blockers" work by counteracting the pro-growth effect caused by adrenaline by affecting the the beta2-adrenoceptor. [More]
Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

Researchers discover new biomarker that puts patients at higher risk for metastasis of uveal melanoma

A study by J. William Harbour, M.D., associate director for Basic Research and leader of the Eye Cancer Site Disease Group at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and colleagues published today in Clinical Cancer Research details the discovery of a biomarker that puts patients at a higher risk for metastasis of uveal melanoma. [More]
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