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Abnormal myelin, not loss of myelin, may drive axon degeneration in myelin diseases

Myelin is an insulating sheath around axons - the processes connecting nerve cells - that is mostly composed of lipids and proteins.

28 Nov 2023

Immune receptor protein linked to healthy aging and lifespan in mice

Life expectancy and healthy aging in mice can be determined by a protein present in some cells of the immune system, according to a study published in the journal Cell Reports.

28 Nov 2023

Researchers take step toward developing cell therapy treatment for MS

An international team has shown that the injection of a type of stem cell into the brains of patients living with progressive multiple sclerosis (MS) is safe, well tolerated and has a long-lasting effect that appears to protect the brain from further damage.

27 Nov 2023

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

In Alzheimer's disease and related dementias, cognitive decline is driven by the overaccumulation of a normal brain protein known as tau.

22 Nov 2023

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

Cleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer's and found that differences in brain immunometabolism – the interactions between the immune system and the ways cells create energy – may contribute to women's increased risk for the disease and its severity.

21 Nov 2023

First-of-its-kind study reveals a new culprit in the formation of brain hemorrhages

A first-of-its-kind study led by the University of California, Irvine has revealed a new culprit in the formation of brain hemorrhages that does not involve injury to the blood vessels, as previously believed.

20 Nov 2023

Curcumin boosts brain delivery of HIV drug, curbing inflammation and oxidative stress

Study shows curcumin enhances antiretroviral delivery and reduces inflammation and oxidative stress in HIV, offering potential improvements in treating HIV-associated neurocognitive disorders.

16 Nov 2023

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Study reveals that senolytics can reduce aging in human brain organoids and mitigate COVID-19 neuropathology, suggesting their potential as a therapeutic strategy against brain aging and coronavirus-related neurological complications.

15 Nov 2023

Microglia found to play crucial role in early human brain development

An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development.

14 Nov 2023

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

In a JAMA Network Open study, researchers found no evidence of neuroinflammation or blood-brain barrier dysfunction in cerebrospinal fluid markers of individuals with post-COVID-19 condition and neuropsychiatric symptoms compared to controls. The study, which assessed cytokines, chemokines, and neuroinflammation markers, suggests that persistent central nervous system immune activation may not be the primary driver of neurological long COVID symptoms.

13 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Hormonal contraceptives taken by adolescents may affect risk assessment behavior

Hormonal contraceptives taken by adolescents may influence development of the brain in a way that alters the recognition of risks, a new study in rats suggests.

13 Nov 2023

Researchers discover a new link between obesity and neurodegenerative disorders

Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer's disease.

7 Nov 2023

Study shows depression increases disability risk in rheumatoid arthritis sufferers

The interactions between rheumatoid arthritis (RA) and major depressive disorder (MDD).

7 Nov 2023

Marijuana's psychoactive compound may alter brain wiring in adolescents

In a mouse study designed to explore the impact of marijuana's major psychoactive compound, THC, on teenage brains, Johns Hopkins Medicine researchers say they found changes to the structure of microglia, which are specialized brain immune cells, that may worsen a genetic predisposition to schizophrenia.

25 Oct 2023

New insights into the molecular basis of schizophrenia during early brain development

Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated.

24 Oct 2023

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Integrated liquid-biopsy proteomics with single-cell transcriptomics from ocular cell types.

24 Oct 2023

Is COVID-19 a risk factor for Alzheimer's disease?

The study explores the interconnected risks between COVID-19 and Alzheimer's Disease (AD), highlighting how SARS-CoV-2 can aggravate AD pathology through neuroinflammation and neurodegeneration. It raises significant concerns about the long-term cognitive implications of COVID-19, especially among those already at risk for AD.

23 Oct 2023

How the gut microbiome contributes to schizophrenia

Researchers explore potential relationships between schizophrenia, the gut microbiome, the gut-brain axis, and short-chain fatty acids.

19 Oct 2023

Turning brain immune cells into neurons restores brain function after stroke-like injury in mice

Researchers at Kyushu University have discovered that turning brain immune cells into neurons successfully restores brain function after stroke-like injury in mice.

18 Oct 2023

Microglia News and Research

Abnormal myelin, not loss of myelin, may drive axon degeneration in myelin diseases

Immune receptor protein linked to healthy aging and lifespan in mice

Researchers take step toward developing cell therapy treatment for MS

Reducing cholesterol esters protects the brain against Alzheimer's-like damage

Sex-specific brain immunometabolism differences may underlie increased Alzheimer's risk in women

First-of-its-kind study reveals a new culprit in the formation of brain hemorrhages

Curcumin boosts brain delivery of HIV drug, curbing inflammation and oxidative stress

Senolytics show promise in combating brain aging and COVID-19 neuropathology

Microglia found to play crucial role in early human brain development

Study reveals no neuroinflammation in long COVID patients with neuropsychiatric symptoms

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Hormonal contraceptives taken by adolescents may affect risk assessment behavior

Researchers discover a new link between obesity and neurodegenerative disorders

Study shows depression increases disability risk in rheumatoid arthritis sufferers

Marijuana's psychoactive compound may alter brain wiring in adolescents

New insights into the molecular basis of schizophrenia during early brain development

Revolutionary approach links protein analysis and single-cell study to uncover disease mechanisms

Is COVID-19 a risk factor for Alzheimer's disease?

How the gut microbiome contributes to schizophrenia

Turning brain immune cells into neurons restores brain function after stroke-like injury in mice

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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