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Chemical compound prevents fungal cells from adhering to surfaces

Targeting serious and sometimes deadly fungal infections, a team of researchers at Worcester Polytechnic Institute (WPI) and the University of Massachusetts Medical School (UMMS) has discovered a chemical compound that prevents fungal cells from adhering to surfaces, which, typically, is the first step of the infection process used by the human pathogen Candida albicans (C. albicans).

14 Aug 2013

Scientist develop mathematical model that predicts how individuals respond to cancer treatment

Vittorio Cristini, PhD, uses the example of an airplane to explain what he does in cancer research. "Before calculus," he says, "people couldn't really design a plane that would fly. You can do it by trial and error, but it would probably take centuries." Dr. Cristini has a faster way to try to understand cancer treatment. Like airplane designers today, he uses a mathematical model.

13 Aug 2013

Strategy that dismantles flu viral genome in human lung cells ensures safe research

A new strategy that dismantles a viral genome in human lung cells will ensure safe research on deadly strains of influenza, say researchers from the Icahn School of Medicine at Mount Sinai.

13 Aug 2013

Bacterial strains that delay cell division might be used to design drugs that stop division entirely

In 1958 a group of scientists working in Denmark made the striking observation that bacterial cells are about twice as large when they are cultured on a rich nutrient source than when they are cultured on a meager one.

13 Aug 2013

Nuevolution forms scientific collaboration to investigate biological mechanism of GPCR drug target

Nuevolution A/S today announced that it has entered into a scientific collaboration with Duke University, the Howard Hughes Medical Institute, and Lexicon Pharmaceuticals, Inc. for the investigation of the biological mechanism of action of a specified GPCR drug target.

13 Aug 2013

Scientists use nanoparticles to regulate DNA interactions in self-assembly, drug-delivery

A team of chemists in SU's Cf ollege oArts and Scientists has used a temperature-sensitive polymer to regulate DNA interactions in both a DNA-mediated assembly system and a DNA-encoded drug-delivery system.

12 Aug 2013

Understanding the movement of neurons sheds light on how cancer cells invade health tissues

The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published August 7 in the online journal PLOS ONE.

8 Aug 2013

Research shows how mammalian and bacterial kingdoms interact

The bacteria Streptococcus pneumoniae harmlessly colonizes the mucous linings of throats and noses in most people, only becoming virulent when they leave those comfortable surroundings and enter the middle ears, lungs or bloodstream. Now, in research published in July in mBio, University at Buffalo researchers reveal how that happens.

8 Aug 2013

ASU expert receives $1.6 million grant to advance microscopy imaging research

At Arizona State University's Biodesign Institute, Nongjian (NJ) Tao has been designing advanced microscopy methods with the ambitious aim of capturing molecular-scale phenomena in living systems. The new techniques, which combine multiple imaging modalities, are poised to revolutionize the study of biology and the development of new drugs.

8 Aug 2013

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

Researchers have discovered a novel mechanism responsible for the loss of a critical tumor-suppressor gene in rhabdomyosarcoma and other soft-tissue sarcomas, rare cancers that strike mainly children and often respond poorly to treatment. Their cause is largely unknown.

8 Aug 2013

TSRI scientists decode important molecular signal that guides development of neocortex

Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex. The largest and most recently evolved region of the brain, the neocortex is particularly well developed in humans and is responsible for sensory processing, long-term memory, reasoning, complex muscle actions, consciousness and other functions.

8 Aug 2013

Teplizumab to block type 1 diabetes proves strikingly effective in phase 2 clinical trial

An experimental drug designed to block the advance of type 1 diabetes in its earliest stages has proven strikingly effective over two years in about half of the patients who participated in the phase 2 clinical trial.

8 Aug 2013

Scientists identify important molecular signal that guides development of brain

Scientists at The Scripps Research Institute (TSRI) have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.

8 Aug 2013

MIT researchers discover platform that manipulates organic molecules' emission

Enhancing and manipulating the light emission of organic molecules is at heart of many important technological and scientific advances, including in the fields of organic light emitting devices, bio-imaging, bio-molecular detection.

7 Aug 2013

Ensemble Therapeutics initiates research and development collaboration with Novartis

Ensemble Therapeutics, a biotechnology company developing Ensemblins, a novel class of small molecule therapeutics with the power of biologics, today announced the initiation of a two-part research and development collaboration with Novartis.

6 Aug 2013

CSIRO scientists create broad spectrum coral sunscreen filters

CSIRO, in partnership with skincare company Larissa Bright Australia, has created the world's first UVA/UVB sunscreen filters which mimic the natural sun protection used by corals on the Great Barrier Reef.

6 Aug 2013

Novel way to dramatically raise potency of drug candidates targeting RNA

Scientists from the Jupiter campus of The Scripps Research Institute (TSRI) have shown a novel way to dramatically raise the potency of drug candidates targeting RNA, resulting in a 2,500-fold improvement in potency and significantly increasing their potential as therapeutic agents.

6 Aug 2013

Nano-machine cell killer offers new insight into fight against pathogens

This is a veritable mechanics of aggression on the nanoscale. Certain bacteria, including Staphylococcus aureus, have the ability to deploy tiny darts. This biological weapon kills the host cell by piercing the membrane.

5 Aug 2013

Combating antibiotic resistance: an interview with Ron Najafi, CEO NovaBay Pharmaceuticals

Approximately 80 years ago the first antibiotic was discovered by Sir Alexander Fleming, for which he was justifiably awarded the Nobel Prize in medicine.

2 Aug 2013

Protein linked to learning induces cocaine addiction, say researchers

A team of researchers says it has solved the longstanding puzzle of why a key protein linked to learning is also needed to become addicted to cocaine. Results of the study, published in the Aug. 1 issue of the journal Cell, describe how the learning-related protein works with other proteins to forge new pathways in the brain in response to a drug-induced rush of the “pleasure” molecule dopamine.

2 Aug 2013

Molecule News and Research

Chemical compound prevents fungal cells from adhering to surfaces

Scientist develop mathematical model that predicts how individuals respond to cancer treatment

Strategy that dismantles flu viral genome in human lung cells ensures safe research

Bacterial strains that delay cell division might be used to design drugs that stop division entirely

Nuevolution forms scientific collaboration to investigate biological mechanism of GPCR drug target

Scientists use nanoparticles to regulate DNA interactions in self-assembly, drug-delivery

Understanding the movement of neurons sheds light on how cancer cells invade health tissues

Research shows how mammalian and bacterial kingdoms interact

ASU expert receives $1.6 million grant to advance microscopy imaging research

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

TSRI scientists decode important molecular signal that guides development of neocortex

Teplizumab to block type 1 diabetes proves strikingly effective in phase 2 clinical trial

Scientists identify important molecular signal that guides development of brain

MIT researchers discover platform that manipulates organic molecules' emission

Ensemble Therapeutics initiates research and development collaboration with Novartis

CSIRO scientists create broad spectrum coral sunscreen filters

Novel way to dramatically raise potency of drug candidates targeting RNA

Nano-machine cell killer offers new insight into fight against pathogens

Combating antibiotic resistance: an interview with Ron Najafi, CEO NovaBay Pharmaceuticals

Protein linked to learning induces cocaine addiction, say researchers

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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