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New custom-designed proteins can efficiently reach intramembrane targets

Hitting targets embedded within the cell membrane has long been difficult for drug developers due to the membrane's challenging biochemical properties. Now, Scripps Research chemists have demonstrated new custom-designed proteins that can efficiently reach these "intramembrane" targets.

13 Mar 2024

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Researchers from Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have uncovered thousands of previously unknown bile acids, a type of molecule used by our gut microbiome to communicate with the rest of the body.

12 Mar 2024

Exploristics and Exonate announce successful collaboration to enhance clinical trial study design using cloud-based simulation

Exploristics’ cloud-based simulation platform KerusCloud used to enhance study design for Exonate’s upcoming Phase IIb study following successful Phase Ib/IIa study.

12 Mar 2024

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State.

11 Mar 2024

LAG-3 protein structure may be the key to unlocking new cancer treatments

A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable the development of new cancer treatments.

11 Mar 2024

Study highlights potential therapeutic target for immune-related disorders

A new study highlights a potential therapeutic target for immune-related disorders, such as multiple sclerosis and asthma.

11 Mar 2024

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Sleep boosts immune cell mobility toward lymph nodes

Researchers at LMU Munich have shown that sleep enhances the migratory potential of T cells toward lymph nodes.

8 Mar 2024

Proteins regulating plasminogen-plasmin levels can help predict COVID-19 severity

The global impact of the COVID-19 pandemic on healthcare systems has been significant. The sudden surge in infected cases overwhelmed hospitals and disrupted routine healthcare services, thus further worsening public health.

7 Mar 2024

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

By dissecting the genetic diversity of the most deadly human malaria parasite – Plasmodium falciparum – researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) have identified a mechanism of 'copy-paste' genetics that increases the genetic diversity of the parasite at accelerated time scales.

7 Mar 2024

UAB study identifies new molecule for treating hypertension

Researchers at the UAB have carried out two revealing studies on TRPV2, a key ion channel in several cellular functions, which points to it as a possible new therapeutic target in the treatment of hypertension.

6 Mar 2024

Deep-learning-enhanced mass spectrometry for biochemical mapping of the brain

Beckman Institute for Advanced Science and Technology researchers Jonathan Sweedler, a professor of chemistry, and Fan Lam, a professor of bioengineering, outlined how spatial omics technologies can reveal the molecular intricacy of the brain at different scales.

6 Mar 2024

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

Scientists discover a new way to disarm a deadly protein that also appears in cancers of the lung, breast and colon.

5 Mar 2024

DNA aptamer-based sensors can accurately detect trace amounts of fentanyl, heroin, and cocaine

Researchers from North Carolina State University have developed a new generation of high-performance DNA aptamers and highly accurate drug sensors for cocaine and other opioids.

5 Mar 2024

Exonate first-in-class eye drop Phase Ib/IIa trial data demonstrate safety and biological activity in treatment of diabetic retinopathy and diabetic macular oedema

EXN407 is the first topical SRPK1 inhibitor to demonstrate both safety and signals of biological response as monotherapy for these indications.

5 Mar 2024

Unlocking the role of lncREST RNA in DNA replication and repair

Researchers at Cima Universidad de Navarra have discovered that a ribonucleic acid that does not contain information to make proteins (long non-coding RNA) plays a crucial role in signalling and repairing errors in DNA replication during cell division.

4 Mar 2024

RAD51 protein identified as a key player in preventing DNA re-replication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent.

4 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Penn engineers develop targeted lung delivery system using lipid nanoparticles

Penn Engineers have developed a new means of targeting the lungs with lipid nanoparticles (LNPs), the miniscule capsules used by the Moderna and Pfizer-BioNTech COVID-19 vaccines to deliver mRNA, opening the door to novel treatments for pulmonary diseases like cystic fibrosis.

1 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Molecule News and Research

New custom-designed proteins can efficiently reach intramembrane targets

Molecular Rosetta stone provides previously unknown insight into gut microbiome communication

Exploristics and Exonate announce successful collaboration to enhance clinical trial study design using cloud-based simulation

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

LAG-3 protein structure may be the key to unlocking new cancer treatments

Study highlights potential therapeutic target for immune-related disorders

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Sleep boosts immune cell mobility toward lymph nodes

Proteins regulating plasminogen-plasmin levels can help predict COVID-19 severity

"Copy-paste" genetic mechanism increases the genetic diversity of malaria parasite

UAB study identifies new molecule for treating hypertension

Deep-learning-enhanced mass spectrometry for biochemical mapping of the brain

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

DNA aptamer-based sensors can accurately detect trace amounts of fentanyl, heroin, and cocaine

Exonate first-in-class eye drop Phase Ib/IIa trial data demonstrate safety and biological activity in treatment of diabetic retinopathy and diabetic macular oedema

Unlocking the role of lncREST RNA in DNA replication and repair

RAD51 protein identified as a key player in preventing DNA re-replication

Unlocking the secrets of T follicular helper cells for better treatment strategies

Penn engineers develop targeted lung delivery system using lipid nanoparticles

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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