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Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Scripps Research scientists uncover plausible pathway for protocell formation

Roughly 4 billion years ago, Earth was developing conditions suitable for life. Origin-of-life scientists often wonder if the type of chemistry found on the early Earth was similar to what life requires today.

29 Feb 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024

New tool can streamline the analysis of complex epigenome and epitranscriptome data

Scientists have extensively researched the structure and sequence of genetic material and its interactions with proteins in the hope of understanding how our genetics and environment interact in diseases.

28 Feb 2024

UB research may offer a more streamlined approach to developing cancer drugs

Drug discovery can be a frustrating process of trial and error.

28 Feb 2024

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

28 Feb 2024

Caffeine's protective effects against obesity and joint diseases supported by genetic study

The effects of caffeine levels in circulation by considering genetically predicted variations in caffeine metabolism.

28 Feb 2024

Fenugreek seeds: A superfood for health and wellness, says new review

Research highlights the dietary significance and potential applications of fenugreek seeds, emphasizing their role in disease prevention, chronic condition management, and providing nutritional value, including their ability to reduce blood sugar and cholesterol levels.

27 Feb 2024

Understanding obesity's effects on liver metabolism

Your liver plays a vital role in your metabolism, the biological process which converts food into energy.

26 Feb 2024

Omalizumab shows promise in preventing food allergy reactions in children, study finds

A drug can make life safer for children with food allergies by preventing dangerous allergic responses to small quantities of allergy-triggering foods, according to a new study led by scientists at the Stanford School of Medicine.

25 Feb 2024

Identifying antiviral protein IFN-γ as a potential biomarker for Long COVID

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression. New research shows that in Long COVID patients, IFN-y production persists until symptoms improve, highlighting a potential biomarker and a target for therapies.

24 Feb 2024

Gut microbial metabolite plays a role in exacerbating thrombosis

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.

23 Feb 2024

Optibrium enables collaborative design in its StarDrop platform

The new Idea Tracker capability further improves the efficiency of drug discovery by supporting project management, idea sharing and molecule design tracking.

23 Feb 2024

Yale chemists synthesize complex anticancer molecules from marine invertebrates

Nearly 30 years ago, scientists discovered a unique class of anticancer molecules in a family of bryozoans, a phylum of marine invertebrates found in tropical waters.

22 Feb 2024

Innovative MicroGlucagon solution aims to transform insulin therapy for type 1 diabetics

Researchers in Trondheim are developing a new medicine for diabetics who have to have daily injections of insulin. The key is a hormone that causes the smallest blood vessels to relax on the inside.

22 Feb 2024

SCIEX’s Jose Castro-Perez Reveals How They're Setting New Standards in Mass Spectrometry

SCIEX’s Reveals How They're Setting New Standards in Mass Spectrometry at SLAS 2024.

From Society for Laboratory Automation and Screening (SLAS) 22 Feb 2024

Selkirk Pharma announces new APS qualified facility with advanced fill/finish capacity in Spokane, WA

Selkirk Pharma, Inc., a privately held U.S. pharmaceutical manufacturer specializing in the fill and finish of injectable drugs, including vaccines and biological therapeutics, today announced the Aseptic Process Simulation (APS) qualification of its sterile manufacturing facility and newly available fill/finish capacity.

From Selkirk Pharma 22 Feb 2024

Study highlights an immunological mechanism underlying Long COVID

SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache and depression.

21 Feb 2024

New mechanism discovered: B cells' contribution to immune tolerance in thymus gland

Immune cells must learn not to attack the body itself. A team of researchers from the Technical University of Munich (TUM) and the Ludwig Maximilian University of Munich (LMU) has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the "training" of the T cells in the thymus gland.

21 Feb 2024

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine's mechanism of action has been unclear.

20 Feb 2024

Molecule News and Research

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Scripps Research scientists uncover plausible pathway for protocell formation

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

New tool can streamline the analysis of complex epigenome and epitranscriptome data

UB research may offer a more streamlined approach to developing cancer drugs

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

Caffeine's protective effects against obesity and joint diseases supported by genetic study

Fenugreek seeds: A superfood for health and wellness, says new review

Understanding obesity's effects on liver metabolism

Omalizumab shows promise in preventing food allergy reactions in children, study finds

Identifying antiviral protein IFN-γ as a potential biomarker for Long COVID

Gut microbial metabolite plays a role in exacerbating thrombosis

Optibrium enables collaborative design in its StarDrop platform

Yale chemists synthesize complex anticancer molecules from marine invertebrates

Innovative MicroGlucagon solution aims to transform insulin therapy for type 1 diabetics

SCIEX’s Jose Castro-Perez Reveals How They're Setting New Standards in Mass Spectrometry

Selkirk Pharma announces new APS qualified facility with advanced fill/finish capacity in Spokane, WA

Study highlights an immunological mechanism underlying Long COVID

New mechanism discovered: B cells' contribution to immune tolerance in thymus gland

Unlocking sulfasalazine's mechanism of action in IBD-SpA patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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