Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

New antibody shows promise in reducing tau proteins associated with Alzheimer's disease

A team led by researchers from Mass General Brigham reports promising results for a monoclonal antibody that takes aim at a new target for Alzheimer's disease.

5 Oct 2023

Organoid medicine reveals promising covid-19 treatment target

When the new SARS-CoV-2 virus began killing thousands of people every week, physicians and scientists around the globe raced to learn why the new pathogen was so deadly.

5 Oct 2023

New study reveals BA.2.86 subvariant's surprising dance with antibodies

Researchers examined the antigenicity of the emerging SARS-CoV-2 subvariant BA.2.86, finding that it is not resistant to neutralizing antibodies from previously infected or vaccinated individuals, although it does show increased binding affinity to the ACE-2 receptor. The study highlights the subvariant's sensitivity and resistance to different classes of monoclonal antibodies, offering insights for future treatment and vaccine development.

2 Oct 2023

How well do current vaccines hold up against new SARS-CoV-2 variants BA.2.86 and FLip?

The study explores the efficacy of three-dose monovalent or bivalent vaccinations in neutralizing newly emerged SARS-CoV-2 variants BA.2.86 and FLip. While BA.2.86 showed lower immune evasion abilities compared to recent XBB variants, it was less effectively neutralized by the monoclonal antibody S309, raising questions about vaccine efficacy against evolving strains.

17 Sep 2023

Combination immunotherapy outperforms durvalumab monotherapy in neoadjuvant NSCLC

Combination immunotherapy with the anti-PD-L1 monoclonal antibody durvalumab and other novel agents outperforms durvalumab alone in the neoadjuvant (pre-surgical) setting for early-stage non-small-cell lung cancer (NSCLC), according to researchers at The University of Texas MD Anderson Cancer Center.

14 Sep 2023

Multi-omics study offers insights into psoriasis treatment

Researchers use a multi-omics approach combining immune cell-enriched scRNA-seq, microarray analysis, and immunohistochemistry to elucidate the translational role of anti-IL-17A in suppressing the autoimmune functions of T17 cells, thereby effectively treating human psoriasis.

14 Sep 2023

Experts propose new definition of clinical remission in treatment of asthma

As an increasing number of improved asthma treatments are developed, a greater number of people with asthma are finding their symptoms under control.

12 Sep 2023

CDC advises healthcare providers on new tools to combat RSV

The CDC predicts increased activity of Respiratory Syncytial Virus (RSV) for the upcoming winter season, urging clinicians to implement new prevention tools like nirsevimab and FDA-approved vaccines for vulnerable populations. The advisory comes as RSV activity shows a changing pattern, affecting infants, children, and adults, and causing thousands of hospitalizations annually.

10 Sep 2023

Mediterranean diet supercharges skin treatment, clears up atopic dermatitis in teen

Study reports on a 14-year-old boy with atopic dermatitis who experienced complete symptom resolution after combining monoclonal antibody treatment with a Mediterranean diet. Highlighting the role of diet in managing inflammatory skin conditions, the case study suggests the therapeutic potential of integrating dietary changes with medical treatment for improved outcomes.

10 Sep 2023

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that supports foralumab’s mechanism as a potential treatment for Alzheimer’s disease (AD), a difficult-to-treat neuroinflammatory disease.

9 Sep 2023

TTUHSC El Paso's community engagement efforts helped address COVID-19 disparities

In summer 2020, Edward Michelson, M.D., chair of TTUHSC El Paso's Department of Emergency Medicine, had developed a new daily routine.

8 Sep 2023

MD Anderson and Panacea create Manaolana Oncology to develop novel portfolio of monoclonal antibodies

The University of Texas MD Anderson Cancer Center and Panacea Venture today announced the launch of Manaolana Oncology Inc., a new company created to develop and advance antibody-based therapies against novel cancer antigens.

6 Sep 2023

Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines

Researchers characterized two novel SARS-CoV-2 XBB variants, EG.5.1 and XBB.2.3.

4 Sep 2023

Big Tuna and automated buffer exchange: An interview with Unchained Labs

In this interview, AZoNetwork speaks with Joe Barco, the Senior Director of Workflow Marketing at Unchained Labs, about the benefits of automated buffer exchange with Big Tuna.

From Unchained Labs 4 Sep 2023

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

A program designed to ensure fairness and that people living in the most disadvantaged U.S. neighborhoods would be offered a scarce, potentially life-saving medication proved feasible in a large health system.

1 Sep 2023

Researchers unearth secrets of zinc transporter protein

A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.

31 Aug 2023

Man-made antibody successfully prevents organ rejection after transplantation

A man-made antibody successfully prevented organ rejection when tested in primates that had undergone a kidney transplant, Duke Health researchers report.

30 Aug 2023

UTMB research potentially points to an effective treatment for Lassa fever

New research out of the University of Texas Medical Branch potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Timing and cost of new vaccines vary by virus and health insurance status

As summer edges toward fall, thoughts turn to, well, vaccines.

24 Aug 2023

Monoclonal Antibody News and Research

Further Reading

New antibody shows promise in reducing tau proteins associated with Alzheimer's disease

Organoid medicine reveals promising covid-19 treatment target

New study reveals BA.2.86 subvariant's surprising dance with antibodies

How well do current vaccines hold up against new SARS-CoV-2 variants BA.2.86 and FLip?

Combination immunotherapy outperforms durvalumab monotherapy in neoadjuvant NSCLC

Multi-omics study offers insights into psoriasis treatment

Experts propose new definition of clinical remission in treatment of asthma

CDC advises healthcare providers on new tools to combat RSV

Mediterranean diet supercharges skin treatment, clears up atopic dermatitis in teen

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

TTUHSC El Paso's community engagement efforts helped address COVID-19 disparities

MD Anderson and Panacea create Manaolana Oncology to develop novel portfolio of monoclonal antibodies

Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines

Big Tuna and automated buffer exchange: An interview with Unchained Labs

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

Researchers unearth secrets of zinc transporter protein

Man-made antibody successfully prevents organ rejection after transplantation

UTMB research potentially points to an effective treatment for Lassa fever

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Timing and cost of new vaccines vary by virus and health insurance status

Antibodies eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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