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New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

Next-generation therapeutics with the potential to successfully treat Lou Gehrig's disease

The hopes of many that ALS (commonly referred to as Lou Gehrig's disease) will one day be a disease of the past, studied in medical textbooks, conquered by the dedication of those who have worked tirelessly to eradicate it might be realized in our lifetime.

6 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Celebrex may one day be used to prevent and even treat breast tumors

The anti-inflammatory drug Celebrex, or celecoxib, reduces tumor mass by encouraging cell death and discouraging both cell proliferation and the sprouting of new blood vessels that feed growing tumors, according to a study reported in the November issue of Molecular Cancer Research.

5 Nov 2004

Body's 'internal marijuana': A new target for treatment of schizophrenia, Parkinson's?

“Endocannabinoids” is an impressive word that sounds like the name for a group of tribal warriors or an ancient people. Actually, it is the scientific term for beneficial molecules produced in the brain that act as “a sort of internal marijuana in our system

4 Nov 2004

Scientists have uncovered a significant new link in the chain of immune system events through which estrogen prevents bone loss

Through research in mice, the scientists discovered that an immune signaling molecule called type b transforming growth factor (TGFb) is responsible for a cascade of events that leads estrogen to prevent bone loss.

29 Oct 2004

Marijuana-like compounds may aid Parkinson's disease, pain and obesity

No longer a pipe dream, new animal research now indicates that marijuana-like compounds can aid a bevy of debilitating conditions, ranging from brain disorders such as amyotrophic lateral sclerosis (ALS) and Parkinson's disease, to pain and obesity.

28 Oct 2004

Key gene that impacts the timing of puberty

Researchers at the OHSU Oregon National Primate Research Center (ONPRC) have identified a key gene that impacts the timing of puberty and can shorten the time span for reproduction.

24 Oct 2004

Genetic research offers insight into Sjögren's syndrome and the general developmental machinery of the immune system

By knocking out a single gene in mice, immunologists at Duke University Medical Center have mimicked a little-understood autoimmune disorder in humans.

21 Oct 2004

Researchers have uncovered a specific signaling mechanism that contributes to the development of colorectal cancer

The discovery furthers the understanding of mechanisms that contribute to disease progression and provides new avenues for development of therapies for colorectal cancer.

21 Oct 2004

Dietary iron imbalances increase the odds of developing Parkinson's disease

You might want to toss those iron-fortified vitamins, because absent a diagnosed deficiency too much of a good thing can be bad.

12 Oct 2004

Protein called Mrp4 blocks the access of the anti-cancer drug topotecan into the brain

A protein called Mrp4 blocks the access of the anti-cancer drug topotecan into the brain by transporting this agent back into the bloodstream, thus reducing the ability of this agent to reach tumors.

11 Oct 2004

Lycopene may be able to inhibit the growth of prostate tumours

A study by Dutch and German researchers has provided evidence that lycopene may be able to inhibit the growth of prostate tumours and that its effect may be enhanced if it is combined with vitamin E.

30 Sep 2004

Functions of the c-myb gene which leukemia cells depend on for proliferation

Today the Proceedings of the National Academy of Sciences publishes a paper by Temple University researchers that details one of the functions of the c-myb gene (which leukemia cells depend on for proliferation), the formation of white blood cells.

27 Sep 2004

Novel strategy for stimulating the production of utrophin

Researchers at the University of Pennsylvania School of Medicine report a novel strategy for stimulating the production of utrophin – an important muscle protein in young mice – for muscular dystrophy therapy.

21 Sep 2004

Certain cancers might one day be cured without the use of toxic chemotherapy and radiation

The eradication of brain tumors in mice following treatment with a novel drug suggests that certain cancers might one day be cured without the use of toxic chemotherapy and radiation.

20 Sep 2004

Link between eosinophils and asthma

Mayo Clinic researchers have used a comparative genomic strategy to demonstrate a causative link between eosinophils, a rare type of white blood cell, and asthma.

18 Sep 2004

Transthyretin discovery may halt progression of Alzheimer's

In a finding that may cause a dramatic shift in the way scientists and researchers search for a therapy for Alzheimer's disease, a team of researchers led by Jeff Johnson, an associate professor at the School of Pharmacy, has discovered that increased expression of a protein called transthyretin in the brain appears to halt the progression of the disease.

10 Sep 2004

Researchers discover that DNA fragments destroy melanoma cells

Researchers at Boston University School of Medicine have discovered that small DNA fragments or oligonucleotides that resemble the telomere (chromosome end), also called T-oligos, can cause human melanoma cells to undergo extensive apoptosis (cell death), while surviving melanoma cells become more differentiated and therefore less aggressive.

1 Sep 2004

Gene - beta1-integrin, could be key to breast cancer therapies

Canadian researchers at the Research Institute of the McGill University Health Centre and McMaster University have identified a new player in breast cancer. This gene, beta1-integrin, has been shown to be critical in the initiation of tumour growth and development in a mouse model of cancer.

30 Aug 2004