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Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

Diabetes accelerates the development of atherosclerosis, increasing the incidence of cardiovascular events.

29 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced "beta") in the pancreas, leading to a lack of insulin and inability to regulate blood sugar.

26 Feb 2024

Researchers uncover crucial role of collateral blood vessels in stroke recovery

Blood vessels that cross-connect adjacent arterial trees regulate blood flow to the brain in stroke patients.

26 Feb 2024

Understanding the role played by HIV in pulmonary hypertension

Across the globe, more than 39 million people are living with the Human Immunodeficiency Virus (HIV), the virus that causes AIDS, including more than 1.3 million new HIV diagnoses last year.

23 Feb 2024

Ketamine variant shows promise in treating social impairments

Well-being is important for everyone, especially when we feel lonely or isolated. Depression is a serious challenge for many people and finding an effective solution is key.

22 Feb 2024

Delta opioid receptor agonist reduces anxiety-like behavior in mice

Anxiety-related disorders can have a profound impact on the mental health and quality of life of affected individuals.

22 Feb 2024

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

A study led by the Center for Biomaterials and Tissue Engineering of the Universitat Politècnica de València, member of Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, in collaboration with the Instituto de Investigación Sanitaria La Fe and the University of Zaragoza proposes a novel approach to slow neuromuscular degeneration in patients with Amyotrophic Lateral Sclerosis.

20 Feb 2024

Missing gut microbes after antibiotics and a high-fat diet may be to blame for sugar-free candy and gum giving you gas

A recent Cell study showed how a high-fat diet and antibiotic exposure could trigger sorbitol intolerance by depleting Clostridia from the gut microbiota.

20 Feb 2024

GV1001 exerts anti-aging effects in triple transgenic Alzheimer's mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, "GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects."

15 Feb 2024

Study demonstrates chemo-preventive properties of alpha-santalol against prostate cancer development

Extracted from the core of sandalwood trees (santalum album tree), sandalwood oil has been used for many centuries by several cultures throughout the world for perfume, soaps, incense and candles.

13 Feb 2024

Scientists discover how oxytocin influences memory in animals

Oxytocin (OXT) is a hormone that is known for its effects on psychological well-being and emotional bonding in animals.

13 Feb 2024

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

12 Feb 2024

Groundbreaking study shows monocytes migrate to brain's emotional centers during stress

Researchers report a mechanism wherein peripheral immune factors could impact central nervous system (CNS) function and behavior under stress.

12 Feb 2024

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

Method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression.

12 Feb 2024

New mouse model illuminates lung cancer's transformation into aggressive variant

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.

8 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Endothelial-mesenchymal transition (EndoMT, also termed as EndMT), a biological process resulting in the formation of mesenchymal (or lineage-committed) phenotypes from endothelial cells (lining blood vessels), plays a crucial role in tumor progression.

7 Feb 2024

Mouse Model News and Research

Unlocking the secrets of T follicular helper cells for better treatment strategies

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

UMass Amherst study targets aplastic anemia with cell retraining approach

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

Researchers uncover crucial role of collateral blood vessels in stroke recovery

Understanding the role played by HIV in pulmonary hypertension

Ketamine variant shows promise in treating social impairments

Delta opioid receptor agonist reduces anxiety-like behavior in mice

Study proposes novel approach to slow neuromuscular degeneration in ALS patients

Missing gut microbes after antibiotics and a high-fat diet may be to blame for sugar-free candy and gum giving you gas

GV1001 exerts anti-aging effects in triple transgenic Alzheimer's mice

Study demonstrates chemo-preventive properties of alpha-santalol against prostate cancer development

Scientists discover how oxytocin influences memory in animals

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Groundbreaking study shows monocytes migrate to brain's emotional centers during stress

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

New mouse model illuminates lung cancer's transformation into aggressive variant

New drug targets key mechanism in ALS, protects motor neurons

Monash-led study unveils potential long-term treatment for lupus

Study shines light on partial endothelial-to-mesenchymal transition in the tumor microenvironment

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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