Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

ACADIA Pharmaceuticals announces results from Phase II study of antipsychotic in Alzheimer's disease psychosis

ACADIA Pharmaceuticals Inc., a biopharmaceutical company focused on the development and commercialization of innovative medicines to address unmet medical needs in central nervous system (CNS) disorders, today announced the presentation of data from the Phase II -019 Study of pimavanserin in Alzheimer's disease psychosis at the 10th Clinical Trials on Alzheimer's Disease meeting in Boston.

3 Nov 2017

Researchers discover quirk of cell aging that could help detect late-onset Alzheimer's

Researchers at The University of Texas Health Science Center at Houston School of Dentistry and McGovern Medical School have discovered a previously unknown characteristic of brain-cell aging that could help detect late-onset Alzheimer's disease decades before symptoms begin.

30 Oct 2017

Novel laboratory model may shine light on development of pediatric high-grade glioma

Pediatric high-grade glioma is the primary cause of cancer death in children. Genesis of these tumors is believed to be driven by mutations in proteins that disrupt fundamental mechanisms governing the development of the human brain.

27 Oct 2017

New study sheds light on normal function of Parkinson's gene

A new study published in the journal Neuron sheds light on the normal function of LRRK2, the most common genetic cause for late-onset Parkinson's disease. The study was supported by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.

26 Oct 2017

Study finds mitochondrial DNA damage in Veterans with Gulf War illness

Researchers say they have found the "first direct biological evidence" of damage in veterans with Gulf War illness to DNA within cellular structures that produce energy in the body.

19 Oct 2017

Penn researchers functionally dissect gene variant linked to FTLD

Seven years ago, Penn Medicine researchers showed that mutations in the TMEM106B gene significantly increased a person's risk of frontotemporal lobar degeneration (FTLD), the second most common cause of dementia in those under 65.

19 Oct 2017

Researchers find gaps in knowledge about causes of symptoms in dementia patients

Behavioral and psychological symptoms are difficult for dementia patients and their caregivers, but despite research efforts, there are still gaps in knowledge about what causes or precipitates these symptoms, according to researchers.

10 Oct 2017

Human minibrains expose psychedelic drug effects, study reveals

A Brazilian study has detected variations in signaling pathways that are associated with neurodegeneration, inflammation, and neural plasticity stimulated by a compound from the dimethyltryptamine family known as 5-MeO-DMT.

10 Oct 2017

Alzheimer's gene can protect against and promote neurological damage

Scientists drilling down to the molecular roots of Alzheimer's disease have encountered a good news/bad news scenario. A major player is a gene called TREM2, mutations of which can substantially raise a person's risk of the disease.

9 Oct 2017

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Removal of a regulatory gene called LSD1 in adult mice induces changes in gene activity that that look unexpectedly like Alzheimer's disease, scientists have discovered.

9 Oct 2017

Study unveils neuronal effects of psychedelics using cerebral organoids

A Brazilian study, published in Scientific Reports on October 09, 2017, has identified changes in signaling pathways associated with neural plasticity, inflammation and neurodegeneration triggered by a compound from the family of dimethyltryptamine known as 5-MeO-DMT.

9 Oct 2017

Study provides insights into non-oncogenic addictions of tumors

Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) and UC San Diego have shown that tumors can ensure a more reliable nutrient supply by eliminating the p62 protein in surrounding stromal tissue.

9 Oct 2017

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

In a recent clinical trial, a gene therapy to treat cerebral adrenoleukodystrophy (CALD) -- a neurodegenerative disease that typically claims young boys' lives within 10 years of diagnosis -- effectively stabilized the disease's progression in 88 percent of patients, researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Massachusetts General Hospital report today.

4 Oct 2017

Study on cell stress response may hold promise for treating inflammation-related disorders

Stress – defined broadly – can have a profoundly deleterious effect on the human body. Even individual cells have their own way of dealing with environmental strains such as ultraviolet radiation from the sun or germs.

4 Oct 2017

Scientists awarded $1.3 million grant to study relationship between traumatic brain injury and dementia

The U.S. Department of Defense has awarded a team of scientists and physicians from leading health care institutions across Phoenix a $1.3 million grant over three years to study traumatic brain injury and its relationship to dementia.

4 Oct 2017

New non-invasive biomarker detects Alzheimer's disease before occurrence of first symptoms

Absence of a prefrontal activation during sensory gating of simple tones detects the Alzheimer's disease (AD) before the occurrence of the first symptoms. Sanja Josef Golubic Ph.D., physicists at the Department of Physics, Faculty of Science, University of Zagreb, reveals the high potential, absolutely non-invasive biomarker of AD pathology in a new study published in the journal Human Brain Mapping. Josef Golubic found a discrete, individual biomarker of AD with "ideal" properties.

3 Oct 2017

Impairing critical partnership between brain cells can lead to Alzheimer's disease

Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration. The study published in Cell Metabolism reports a mechanism by which two types of brain cells, neurons and glia, normally support each other's functions.

30 Sep 2017

FAU neuroscientist develops innovative program to prevent dementia

More than 5 million Americans today are affected by Alzheimer's disease (AD). If nothing is done to stop this upward trajectory, there will be more than 16 million people with AD in the United States and more than 60 million people with AD worldwide by 2050.

27 Sep 2017

Study uses new approach to model brain connections for understanding Parkinson's disease

Some 10 million people worldwide suffer from Parkinson's disease -- a debilitating condition that causes degeneration of brain nerve cells that control movement. The exact reasons for this degeneration remain unknown.

27 Sep 2017

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Sanford Burnham Prebys Medical Discovery Institute is pleased to announce the National Institute on Drug Abuse at the National Institutes of Health has awarded Nicholas Cosford, Ph.D., a three-year, $10.8 million grant to pursue the preclinical development of a new class of medicine to treat substance use disorders.

26 Sep 2017

Neurodegeneration News and Research

Further Reading

ACADIA Pharmaceuticals announces results from Phase II study of antipsychotic in Alzheimer's disease psychosis

Researchers discover quirk of cell aging that could help detect late-onset Alzheimer's

Novel laboratory model may shine light on development of pediatric high-grade glioma

New study sheds light on normal function of Parkinson's gene

Study finds mitochondrial DNA damage in Veterans with Gulf War illness

Penn researchers functionally dissect gene variant linked to FTLD

Researchers find gaps in knowledge about causes of symptoms in dementia patients

Human minibrains expose psychedelic drug effects, study reveals

Alzheimer's gene can protect against and promote neurological damage

Researchers propose LSD1 protein as central player in Alzheimer's and FTD

Study unveils neuronal effects of psychedelics using cerebral organoids

Study provides insights into non-oncogenic addictions of tumors

Gene therapy effectively stabilizes progression of cerebral adrenoleukodystrophy, trial reveals

Study on cell stress response may hold promise for treating inflammation-related disorders

Scientists awarded $1.3 million grant to study relationship between traumatic brain injury and dementia

New non-invasive biomarker detects Alzheimer's disease before occurrence of first symptoms

Impairing critical partnership between brain cells can lead to Alzheimer's disease

FAU neuroscientist develops innovative program to prevent dementia

Study uses new approach to model brain connections for understanding Parkinson's disease

SBP researcher awarded $10.8 million grant to pursue development of new drug for substance abuse

Aneuro: A Year of Neuroscience in Review eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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