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NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

NIPS researchers reveal new mechanisms by which microglia sculpt neural circuits

Microglia are cells that combat various brain diseases and injuries by swallowing foreign or disruptive objects and releasing molecules that activate repair mechanisms. [More]
Study suggests structural changes in the brain help cope with stressful situations

Study suggests structural changes in the brain help cope with stressful situations

People who experience job loss, divorce, death of a loved one or any number of life's upheavals often adopt coping mechanisms to make the situation less traumatic. [More]
DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

DNA methylation changes that alter excitability may be involved in neuropsychiatric diseases

Diseases such as epilepsy, neuropathic pain, anxiety, depression, drug addiction and Alzheimer's are all associated with changes in the excitability of brain neurons. [More]
Abnormal increase in hippocampal activity impairs memory and attention

Abnormal increase in hippocampal activity impairs memory and attention

Neurons in the brain interact by sending each other chemical messages, so-called neurotransmitters. [More]
Scientists reveal role of lysosomal vesicles in spread of Parkinson's disease

Scientists reveal role of lysosomal vesicles in spread of Parkinson's disease

Scientists from the Institut Pasteur have demonstrated the role of lysosomal vesicles in transporting α-synuclein aggregates, responsible for Parkinson's and other neurodegenerative diseases, between neurons. [More]
Neuroscientists demonstrate revolutionary new way of mapping the brain at single-neuron resolution

Neuroscientists demonstrate revolutionary new way of mapping the brain at single-neuron resolution

Neuroscientists today publish in Neuron details of a revolutionary new way of mapping the brain at the resolution of individual neurons, which they have successfully demonstrated in the mouse brain. [More]
Research findings offer more insight into complexity and robustness of the brain

Research findings offer more insight into complexity and robustness of the brain

The brain is well capable of coping with the erratic way individual brain cells transmit information. [More]
Researchers find potential way to reduce effects of TBI with neuron-targeting nanoparticle

Researchers find potential way to reduce effects of TBI with neuron-targeting nanoparticle

A fall down the stairs, a car crash, a sports injury or an explosive blast can all cause traumatic brain injury (TBI). [More]
Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

Modifying huntingtin protein protects against behavioral symptoms in Huntington's model mice

There is new hope in the fight against Huntington's disease. Scientists at the Gladstone Institutes discovered that changing a specific part of the huntingtin protein prevented the loss of critical brain cells and protected against behavioral symptoms in a mouse model of the disease. [More]
First investigational treatment for infantile-onset SMA shows promising results in clinical trial

First investigational treatment for infantile-onset SMA shows promising results in clinical trial

A major milestone was reached when nusinersen, an investigational treatment for spinal muscular atrophy (SMA), was shown to significantly improve achievement of motor milestones in babies with infantile-onset SMA, according to an interim analysis of the double-blind, randomized, placebo controlled Phase 3 clinical trial called ENDEAR. [More]
Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers develop new strategy to convert fibroblasts directly into neuronal cells

Researchers have used CRISPR -- a revolutionary new genetic engineering technique -- to convert cells isolated from mouse connective tissue directly into neuronal cells. [More]
Scientists activate neurons in the mouse brain by injecting virus containing light-sensitive proteins

Scientists activate neurons in the mouse brain by injecting virus containing light-sensitive proteins

Neurons that fire together really do wire together, says a new study in Science, suggesting that the three-pound computer in our heads may be more malleable than we think. [More]
Understanding brain circuit development: an interview with Dr Hollis Cline

Understanding brain circuit development: an interview with Dr Hollis Cline

There's a tremendous amount known about brain circuit development. Our work was inspired by experiments that were done over 50 years ago by scientists at Harvard University, Hubel and Wiesel. They received a Nobel Prize for their work and have inspired many additional experiments over the last 50 or 60 years. [More]
UW Medicine researchers discover new type of neuron in mouse retina

UW Medicine researchers discover new type of neuron in mouse retina

In the retina of mice, a new type of neuron that falls outside century-old classifications has been discovered. [More]
Scientists unravel effect of prion proteins on the nerves

Scientists unravel effect of prion proteins on the nerves

Ever since the prion gene was discovered in 1985, its role and biological impact on the neurons has remained a mystery. [More]
Botulinum toxins may cause remote effects by moving between neurons

Botulinum toxins may cause remote effects by moving between neurons

The botulinum toxins are among the deadliest substances on Earth, and two specific toxins — including the popular drug Botox — have multiple uses for treating many neuromuscular conditions, including frown lines, disabling muscle spasms and migraine headaches. [More]
Scientists find efficient and easy way to mass produce GABAergic neurons for laboratory use

Scientists find efficient and easy way to mass produce GABAergic neurons for laboratory use

Scientists from Singapore have streamlined the process of using human stem cells to mass produce GABAergic neurons (GNs) in the laboratory. [More]
MIT scientists design new microfluidic device that mimics neuromuscular junction

MIT scientists design new microfluidic device that mimics neuromuscular junction

MIT engineers have developed a microfluidic device that replicates the neuromuscular junction -- the vital connection where nerve meets muscle. [More]
New biochip test helps identify individuals at increased risk of Alzheimer's disease

New biochip test helps identify individuals at increased risk of Alzheimer's disease

Researchers today unveiled results from a new blood test to help identify which patients are at an elevated risk of Alzheimer's disease. [More]
Scientists uncover genetic cause of rare pediatric progressive neuropathy

Scientists uncover genetic cause of rare pediatric progressive neuropathy

Researchers from the National Institutes of Health and their colleagues identified the genetic cause and a possible therapeutic target for a rare form of pediatric progressive neuropathy. [More]
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