Osteoblast News and Research

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Scientists explore how nanoscale topographies affect cellular regenerative responses

Researchers are trying to find ways to control cellular response in vitro using engineered materials in a continuous pursuit to regenerate injured or diseased tissues.

10 Nov 2016

TMDU researchers develop new double-layered cell transfer technology for effective bone repair

Various technologies have been developed to introduce laboratory-grown bone-forming cells into bone defects to promote their repair.

7 Oct 2016

Stem cells may be responsible for vascular calcification in patients with kidney disease

Scientists have implicated a type of stem cell in the calcification of blood vessels that is common in patients with chronic kidney disease.

8 Sep 2016

TMDU researchers inject gelatin-based gel carrying protein/peptide drugs to trigger bone augmentation

The part of the jawbone containing tooth sockets is known as alveolar bone, and its loss over time or following dental disease may ultimately result in tooth loss.

23 Aug 2016

Novel stem cell-containing bio-ink allows 3D printing of complex tissues for surgical implants

Scientists at the University of Bristol have developed a new kind of bio-ink, which could eventually allow the production of complex tissues for surgical implants.

23 Jun 2016

Metal ions released by implant wear can damage progenitors of bone-forming cells

In metal-on-metal pairings, both the shell and head of an implant consist of a cobalt-chromium-molybdenum alloy. The release of metal ions into the body has been reported as a result of implant wear. Bone loss (osteolysis) was observed in many cases.

22 Jun 2016

$Sostdc1 gene may play vital role in fracture healing process$

Sostdc1 gene may play vital role in fracture healing process

New identification of a gene involved in the fracture healing process could lead to the development of new therapeutic treatments for difficult-to-heal injuries.

2 Jun 2016

New mice study unveils mystery of why chronic stress, depression can lead to bone loss

A new study has helped to unveil the mystery of why chronic stress and depression can lead to bone loss and increase the risk of fractures.

19 May 2016

Development of atherosclerosis can increase osteoporosis risk

Patients with atherosclerosis—the buildup of cholesterol and fat in arteries—are at a higher risk of osteoporosis. A new study published in the American Journal of Physiology—Endocrinology and Metabolism shows how the development of atherosclerosis encourages the loss of bone density.

6 May 2016

Psoriasis patients experience widespread bone loss

Researchers from the Genes, Development and Disease Group, headed by Erwin Wagner at the Spanish National Cancer Research Centre have discovered that psoriasis patients experience a widespread bone loss as a result of the disease.

17 Mar 2016

Study provides insights into cellular mechanisms that may contribute to new osteoarthritis treatments

Researchers show that the protein CCN4 positively regulates the generation of cartilage matrix, which are depleted in osteoarthritis.

2 Mar 2016

Low-sodium intake has little impact on bone health in postmenopausal women

A low-salt diet does not necessarily translate to stronger bones in postmenopausal women, physician-scientists report.

26 Feb 2016

Scientific breakthrough could contribute to early diagnosis of osteoporosis, Alzheimer's

Scientists from the University of Granada have developed a new fluorescent dye capable of detecting, in a single test lasting 20 minutes, the presence of phosphate and biothiol inside living cells. This scientific breakthrough could contribute significantly to the early diagnosis of diseases such as osteoporosis, Alzheimer's, type 2 diabetes, and prostate cancer, since abnormal levels of both substances are associated with these diseases.

30 Jan 2016

Research points to potential use of radiotherapy in treating systemic cancer

An international team of researchers lead by the University of Granada has proven that mesenchymal stem cells (MSC) may be used as enhancer agents of local and systemic effects of radiotherapy, that is to say, those which affect the irradiated tumour and tumour cells located at a certain distance of the irradiated ones.

30 Jan 2016

Research shows how scientists altered stem cells, triggered bone growth

Imagine you have a bone fracture or a hip replacement, and you need bone to form, but you heal slowly - a common fact of life for older people. Instead of forming bone, you could form fat. Researchers at the University of North Carolina School of Medicine may have found a way to tip the scale in favor of bone formation. They used cytochalasin D, a naturally occurring substance found in mold, as a proxy to alter gene expression in the nuclei of mesenchymal stem cells to force them to become osteoblasts (bone cells).

17 Nov 2015

Study demonstrates potential of FCPCs as new source for cartilage regeneration

The self-repair of injured cartilage is difficult for several reasons, foremost of which is the lack of blood supply to the tissue. Therapeutic efforts aimed at cartilage repair are often not optimal. Surgical repair techniques often lead to the formation of fibrocartilage, which is weaker and less durable. Although cell transplantation aimed at cartilage repair has been carried out using mesenchymal stem cells (MSCs), varying outcomes have resulted, despite the propensity of MSCs to proliferate and differentiate.

23 Sep 2015

$Common Alzheimer's disease drug increases bone density, reduces fracture risks$

Common Alzheimer's disease drug increases bone density, reduces fracture risks

The most common drug used to treat Alzheimer's disease increases bone mass in mice, according to one of the first research articles published in the new open access journal Heliyon. The authors of the study, from Saitama Medical University in Japan, say this means the drug could also be used to treat bone loss diseases like osteoporosis and periodontitis, following further clinical research.

21 Sep 2015

Transplanting mesenchymal stromal cells derived from amniotic membranes can benefit eye diseases

A team of researchers in South Korea has successfully transplanted mesenchymal stromal cells (MSCs) derived from human amniotic membranes of the placenta (AMSCs) into laboratory mice modeled with oxygen-induced retinopathy (a murine model used to mimic eye disease).

20 Aug 2015

Cell transplantation researchers successfully treat laboratory rats modeled with severe burns

Cell transplantation researchers have successfully used bone marrow-derived mesenchymal stromal cells (MSCs) to treat a variety of diseases and conditions. Now, using injections of MSCs, a research team in Brazil has successfully treated laboratory rats modeled with severe burns.

25 Jun 2015

New article shows taxonomic classification of rare genetic bone disorders based on metabolic phenotypes

An International Osteoporosis Foundation Working Group on Skeletal Rare Diseases has published a new classification of rare genetic metabolic bone disorders (RGMBDs) according to their metabolic pathogenesis.

18 Jun 2015