Pathogen News and Research

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Viral loads peak before symptom onset in COVID-19

By reviewing published literature on viral loads and viral shedding, researchers found that viral loads for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)peak before symptoms are seen. This has substantial implications for prevention strategies.

5 Oct 2020

Researchers determine the predictability of Ebola's trajectory in China and throughout Southeast Asia

What exactly happened in Asia that caused SARS-CoV-2 to rapidly spread across the region and then essentially came to a halt there? That's what researchers from the University of South Florida are trying to determine in a new study funded by an NSF Rapid Response grant.

5 Oct 2020

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

A large group of researchers from the United States reported developing an amplification-free CRISPR-based mobile phone assay for direct detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from nasal swabs. Their state-of-the-art paper is currently available on the medRxiv* preprint server.

4 Oct 2020

Fecal microbiota transplantation restores gut microbial development in cesarean-born infants

The human gut contains a diverse ecosystem of microbes: mainly bacteria, as well as viruses and fungi, termed the gut microbiota. Recent years have shown that the gut microbiota have widespread effects on the overall functioning of the host's body.

1 Oct 2020

Compounds repurposed from malaria treatment can kill diarrheal pathogen

A class of compounds used for malaria treatment also kill the intestinal parasite Cryptosporidium, a leading cause of diarrheal disease and death in children that has no cure, a multi-institution collaboration of researchers found in a new study.

1 Oct 2020

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Specialized immune cells settle permanently in various tissues of the body and build "local task forces". Scientists from Würzburg have now discovered, how these cell populations can renew locally and can adapt to their specific environment.

1 Oct 2020

Researchers identify pathogen responsible for creeping migration of fat in Crohn's patients

In many patients with Crohn's disease, abdominal fat migrates to the wall of the inflamed small intestines. What prompts the fat tissue to "creep" through the abdomen and wrap around the intestines of many patients with this inflammatory bowel disease (IBD) has been an enduring mystery.

1 Oct 2020

Scientists discover bacteria linked to post-infectious hydrocephalus in infants

Scientists at the Center for Infection and Immunity at Columbia University Mailman School of Public Health have discovered bacteria linked to post-infectious hydrocephalus (PIH), the most common cause of pediatric hydrocephalus worldwide.

30 Sep 2020

Abacus Diagnostica's new multiplex assay provides reliable influenza, COVID-19 diagnosis in 75 minutes

Abacus Diagnostica is a small Finnish company developing and manufacturing assays and devices for rapid molecular diagnostics. Since the beginning of COVID-19 outbreak the company has worked decisively on the development of SARS-CoV-2 diagnostics.

30 Sep 2020

Study shows tofacitinib drug can repair permeability defects in the intestine

A team of researchers led by biomedical scientist Declan F. McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis and ulcerative colitis, can repair permeability defects in the intestine.

30 Sep 2020

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

The novel product, called INNA-051, is being developed by Ena Respiratory, and laboratory experiments have shown that it reduced viral replication by as much as 96 percent in the animal study. Spearheaded by Public Health England’s (PHE) Deputy Director, Professor Miles Carroll, the new study described the potential treatment and has been published in the open-source preprint server bioRxiv*.

29 Sep 2020

Common cold in the past may provide some protection from COVID-19

Seasonal colds are by all accounts no fun, but new research suggests the colds you've had in the past may provide some protection from COVID-19.

29 Sep 2020

PrimeStore® MTM novel viral transport media successfully evaluated by Public Health England for SARS-CoV-2 inactivation

EKF Diagnostics announces that the novel viral transport media PrimeStore® MTM has been successfully evaluated for effective SARS-CoV-2 inactivation.

From EKF Diagnostics 29 Sep 2020

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

A multicenter phase 1/2a randomized, double-blinded, placebo-controlled clinical trial has been conducted recently to evaluate the safety, reactogenicity, and immunogenicity of a non-replicating adenovirus-based vaccine, namely Ad26.COV2.S against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection.

28 Sep 2020

Hamsters and ferrets clear low dose SARS-CoV-2 infection in 14 days

A recent study by French researchers has demonstrated that experimental exposure to severe acute respiratory coronavirus 2 (SARS-CoV-2) is capable of inducing mild infection in hamsters and ferrets within 7 – 10 days of exposure. However, the infection completely resolves within 14 days. The study is currently available on the bioRxiv preprint server.

28 Sep 2020

Resveratrol and pterostilbene inhibit SARS-CoV-2 infection in vitro

A team of scientists at the University of Groningen, in the Netherlands, demonstrates that a natural plant product, resveratrol, and its structural analog, pterostilbene, have long-lasting antiviral effects against severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the bioRxiv preprint server.

28 Sep 2020

Pathogen News and Research

Viral loads peak before symptom onset in COVID-19

Researchers determine the predictability of Ebola's trajectory in China and throughout Southeast Asia

Rapid detection of SARS-CoV-2 with portable CRISPR-based mobile phone diagnostic test

Fecal microbiota transplantation restores gut microbial development in cesarean-born infants

Compounds repurposed from malaria treatment can kill diarrheal pathogen

Study reveals how ILCs develop, adapt, specialize in specific tissue environments

Researchers identify pathogen responsible for creeping migration of fat in Crohn's patients

Scientists discover bacteria linked to post-infectious hydrocephalus in infants

Abacus Diagnostica's new multiplex assay provides reliable influenza, COVID-19 diagnosis in 75 minutes

Study shows tofacitinib drug can repair permeability defects in the intestine

Australian scientists develop a nasal spray that could stop SARS-CoV-2 infection

Common cold in the past may provide some protection from COVID-19

PrimeStore® MTM novel viral transport media successfully evaluated by Public Health England for SARS-CoV-2 inactivation

J&J's COVID-19 vaccine shows potent immune response in phase 2 human trial

Hamsters and ferrets clear low dose SARS-CoV-2 infection in 14 days

Resveratrol and pterostilbene inhibit SARS-CoV-2 infection in vitro

Mapping the evolutionary profile of SARS-CoV-2 and COVID-19 using mutation order approach

Researchers decipher how the immune system memorizes pathogens after an infection

Genetic mutations hinder immune response in severe COVID-19

SARS-CoV-2 emergence linked with decrease in circulation of common respiratory viruses

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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