Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study reveals circadian disruption is a risk factor in alcoholic liver disease

Thirty percent of severe alcoholics develop liver disease, but scientists have not been able to explain why only a subset is at risk. A research team from Northwestern University and Rush University Medical Center now has a possible explanation: disrupted sleep and circadian rhythms can push those vulnerable over the edge to disease.

2 Jul 2013

Director of Molecular Diagnostics receives AMP 2013 Leadership Award

Jan A. Nowak, PhD, MD, has been awarded the Association for Molecular Pathology 2013 Leadership Award. This is the highest honor that AMP gives exclusively to one of its members - one who has demonstrated exceptional leadership in the accomplishment of the mission and vision of AMP.

1 Jul 2013

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

A single systemic dose of special immune cells prevented rejection for almost four months in a preclinical animal model of kidney transplantation, according to experts at the University of Pittsburgh School of Medicine.

1 Jul 2013

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

A biomarker reflecting expression levels of two genes in tumor tissue may be able to predict which women treated for estrogen-receptor (ER)-positive breast cancer should receive a second estrogen-blocking medication after completing tamoxifen treatment.

30 Jun 2013

Decorin protein in blood inhibits tumor progression, say researchers

Researchers from Thomas Jefferson University's Kimmel Cancer Center have discovered that decorin, a naturally occurring protein that circulates in the blood, acts as a potent inhibitor of tumor growth modulating the tumor microenvironment.

28 Jun 2013

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Scientist at Charité - Universitätsmedizin Berlin have used a computer simulation for predicting the effectiveness of various combination therapies for colon tumors. The study has been published in the current issue of the professional journal Molecular Systems Biology*.

28 Jun 2013

Mary Ann Liebert, ATA announce major plans for expansion of Thyroid journal

Mary Ann Liebert, Inc., publishers and the American Thyroid Association announced major plans for the expansion of the flagship journal Thyroid to include two additional important components to better serve the thyroid community and to foster optimal patient care.

28 Jun 2013

Mouse models demonstrate new potential target in fight against Alzheimer's disease

Building on research published eight years ago in the journal Chemistry and Biology, Kenneth S. Kosik, Harriman Professor in Neuroscience and co-director of the Neuroscience Research Institute (NRI) at UC Santa Barbara, and his team have now applied their findings to two distinct, well-known mouse models, demonstrating a new potential target in the fight against Alzheimer's and other neurodegenerative diseases.

27 Jun 2013

Johns Hopkins students design device to reduce need for repeated breast cancer surgeries

When a breast tumor is detected, many women opt to have a lumpectomy, which is surgery designed to remove the diseased tissue while preserving the breast. But during this procedure, doctors cannot learn right away whether all of the cancerous tissue has been removed, with no microscopic signs that cancer cells were left behind.

26 Jun 2013

Immunohistochemistry could be a reliable and cost-effective diagnostic approach for lung cancer

ALK rearrangement has been demonstrated to be a potent oncogenic driver and a promising therapeutic target in non-small cell lung cancer (NSCLC). It defines a distinct molecular subset of NSCLC, in particular adenocarcinoma that can benefit by the treatment of ALK-inhibitors.

26 Jun 2013

Report alerts clinicians, public about catastrophic dangers of contaminated epidural injections

Investigators from the Centers for Disease Control and Prevention describe pathologic findings from 40 case reports of fungal infection in patients who had been given contaminated epidural, paraspinal, or intra-articular (into joints) steroid injections and correlate these findings with clinical and laboratory data.

26 Jun 2013

Study: Active surveillance does not appear to be good idea for black men with prostate cancer

A Johns Hopkins study of more than 1,800 men ages 52 to 62 suggests that African-Americans diagnosed with very-low-risk prostate cancers are much more likely than white men to actually have aggressive disease that goes unrecognized with current diagnostic approaches.

26 Jun 2013

Karo Bio extends research collaboration with Pfizer on RORgamma modulators

Karo Bio AB announced today the extension of its existing research collaboration with Pfizer Inc. on RORgamma modulators to the end of 2014. Pfizer will continue to provide full funding for the research costs.

26 Jun 2013

A paradigm shift for treatment of muscular dystrophy

Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic approach that has proven effective in treating muscular dystrophy in a mouse model.

26 Jun 2013

Caspase-2 protein contributes to cognitive decline associated with Alzheimer's disease

Researchers at Columbia University Medical Center have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease.

26 Jun 2013

Research paper reveals Cav-1 protein's role in prostate tumor microenvironment

Researchers at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute have uncovered for the first time the vital role a popular protein plays in the stroma, the cell-lined area outside of a prostate tumor.

26 Jun 2013

Researchers hope voice therapy in aging humans may help improve quality of life

A new study shows that the vocal training of older rats reduces some of the voice problems related to their aging, such as the loss of vocal intensity that accompanies changes in the muscles of the larynx. This is an animal model of a vocal pathology that many humans face as they age.

25 Jun 2013

Physician earns Outstanding District Service Award from ACOG

Patrick Sweeney, MD, MPH, PhD, a long-time member of the medical staff at Women & Infants Hospital of Rhode Island and professor of obstetrics and gynecology at The Warren Alpert Medical School of Brown University, was recently presented with the Outstanding District Service Award by the American College of Obstetricians and Gynecologists (ACOG).

25 Jun 2013

TGen, Ventana sign research agreement to develop diagnostic markers for cancer

The Translational Genomics Research Institute and Ventana Medical Systems, Inc., a member of the Roche Group, today announced a collaborative research agreement to discover and develop diagnostic markers for treating cancer.

25 Jun 2013

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

Gene mutations that cause cell signaling networks to go awry during embryonic development and lead to major birth defects may also cause subtle disruptions in the brain that contribute to psychiatric disorders such as schizophrenia, autism, and bipolar disorder, according to new research by UC San Francisco scientists.

25 Jun 2013

Pathology News and Research

Further Reading

Study reveals circadian disruption is a risk factor in alcoholic liver disease

Director of Molecular Diagnostics receives AMP 2013 Leadership Award

Research: Systemic dose of dendritic cells prevent rejection in kidney transplantation

Biomarker indicates which women are at risk for breast cancer recurrence after tamoxifen

Decorin protein in blood inhibits tumor progression, say researchers

Computer simulation for predicting effectiveness of combination therapies for colon tumors

Mary Ann Liebert, ATA announce major plans for expansion of Thyroid journal

Mouse models demonstrate new potential target in fight against Alzheimer's disease

Johns Hopkins students design device to reduce need for repeated breast cancer surgeries

Immunohistochemistry could be a reliable and cost-effective diagnostic approach for lung cancer

Report alerts clinicians, public about catastrophic dangers of contaminated epidural injections

Study: Active surveillance does not appear to be good idea for black men with prostate cancer

Karo Bio extends research collaboration with Pfizer on RORgamma modulators

A paradigm shift for treatment of muscular dystrophy

Caspase-2 protein contributes to cognitive decline associated with Alzheimer's disease

Research paper reveals Cav-1 protein's role in prostate tumor microenvironment

Researchers hope voice therapy in aging humans may help improve quality of life

Physician earns Outstanding District Service Award from ACOG

TGen, Ventana sign research agreement to develop diagnostic markers for cancer

UCSF scientists explore how Dact1 mutations contribute to psychiatric disorders

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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