Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study links Agent Orange exposure to neurodegenerative diseases

Agent Orange, an herbicide used during the Vietnam War, is a known toxin with wide-ranging health effects.

14 Feb 2024

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors

Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.

14 Feb 2024

Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Identification of specific gene fusions is critical for the successful targeted treatment of pediatric cancer patients.

13 Feb 2024

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Multiple system atrophy is a rare and fatal neurodegenerative disease, where insoluble inclusions of the protein alpha-synuclein appear in oligodendrocyte cells of the brain.

12 Feb 2024

Immune system in the blood of Alzheimer's patients found to be epigenetically altered

A new Northwestern Medicine study has found the immune system in the blood of Alzheimer's patients is epigenetically altered.

9 Feb 2024

DDT exposure found to alter sperm epigenome in humans

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.

9 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

Do lifestyle factors affect late-life cognition and dementia pathology impact?

Scientists from the Rush University Medical Center in Chicago, United States, investigated whether brain pathology related to dementia, such as cerebrovascular pathology, phosphorylated tau fibril tangles, and β-amyloid accumulation, modify the association between healthy lifestyle choices and cognition during the later years in life.

7 Feb 2024

Pomegranate seed oil boosts brain function in mild cognitive impairment study

Study demonstrates that pomegranate seed oil (PSO) combined with the Mediterranean Diet (MeDi) significantly enhances cognitive functions in individuals with mild cognitive impairment (MCI), suggesting PSO as a potential natural intervention for cognitive health.

5 Feb 2024

Shared molecular pathways found in Alzheimer's and epilepsy

Study reveals shared brain proteomic signatures in Alzheimer’s disease and epilepsy, suggesting common molecular mechanisms that could pave the way for unified therapeutic strategies.

5 Feb 2024

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Researchers uncover that the Xist ribonucleoprotein complex, unique to females, is a key driver of sex-biased autoimmunity, offering new insights into autoimmune disorders' higher prevalence in women.

4 Feb 2024

Gut health linked to Alzheimer's progression, study suggests diet as potential therapy

Study reviews the intricate relationship between diet, gut microbiome diversity, and Alzheimer’s disease progression, suggesting gut health could play a key role in managing the disease.

3 Feb 2024

New study identifies key role of microRNA-29 in scar-free wound healing

New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar).

2 Feb 2024

Researchers find new clue to treating aggressive Wilms tumor subtype

An international team, led by researchers at Nagoya University in Japan, may have determined why the diffuse anaplasia (DA) subtype of Wilms tumor (WT) resists chemotherapy.

2 Feb 2024

Long COVID and ME/CFS share isimilarities in immune system dysfunction, study finds

A study led by UMass Chan Medical School viral immunologists Liisa Selin, MD, PhD, and Anna Gil, PhD, discovered similarities in immune system dysfunction as a potential biomarker among people living with long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

1 Feb 2024

New microscopy technology unveils detailed images of brain cancer tissue

Brigham and MIT researchers uncovered never-before-seen details in human brain tissue with new, inexpensive microscopy technology.

1 Feb 2024

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

A combination of two cancer drugs could be effective against malignant peripheral nerve sheath tumors (MPNSTs) -; soft tissue tumors that are stubbornly resistant to chemotherapy and radiation -; according to a laboratory study led by researchers at the Johns Hopkins Kimmel Cancer Center.

31 Jan 2024

Do deep learning tools outperform humans in diagnosing breast cancer via ultrasound imaging?

The accuracy of deep learning (DL) in diagnosing breast cancer using ultrasound (US) compared to human readers in clinical settings.

31 Jan 2024

Cadaveric pituitary-derived growth hormone delivery influences iatrogenic Alzheimer’s Disease

Recipients of cadaver-derived pituitary growth hormone (c-hGH) developed biomarker changes in the realm of Alzheimer’s disease (AD).

31 Jan 2024

Pathology News and Research

Further Reading

Study links Agent Orange exposure to neurodegenerative diseases

Phosphoproteomic profiling reveals the complex interplay of immune cells in tumors

Novel assay enhances pediatric cancer treatment by identifying clinically relevant gene fusions

Cytokine interferon-gamma can be a disease-modifying therapeutic target in multiple system atrophy

Immune system in the blood of Alzheimer's patients found to be epigenetically altered

DDT exposure found to alter sperm epigenome in humans

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

Do lifestyle factors affect late-life cognition and dementia pathology impact?

Pomegranate seed oil boosts brain function in mild cognitive impairment study

Shared molecular pathways found in Alzheimer's and epilepsy

Xist lncRNA identified as key trigger in female-biased autoimmune diseases

Gut health linked to Alzheimer's progression, study suggests diet as potential therapy

New study identifies key role of microRNA-29 in scar-free wound healing

Researchers find new clue to treating aggressive Wilms tumor subtype

Long COVID and ME/CFS share isimilarities in immune system dysfunction, study finds

New microscopy technology unveils detailed images of brain cancer tissue

Combination drug treatment could be effective against malignant peripheral nerve sheath tumors

Do deep learning tools outperform humans in diagnosing breast cancer via ultrasound imaging?

Cadaveric pituitary-derived growth hormone delivery influences iatrogenic Alzheimer’s Disease

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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