Pathophysiology News and Research

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Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases

A new study by Professors Martti Juhola and Katriina Aalto-Setälä of the University of Tampere in Finland demonstrates that with the use of artificial intelligence and machine learning, it is possible not only to accurately sort sick cardiac cell cultures from healthy ones, but also to differentiate between genetic cardiac diseases.

20 Jun 2018

Novel chip can be used to identify rhinovirus strains as cause of asthma

MedUni Vienna has developed a method that can be used to identify individual rhinovirus strains ("cold viruses") as a cause of asthma.

18 Jun 2018

Studies provide insight into molecular changes prior to onset of arthritis

The results of two studies presented today at the Annual European Congress of Rheumatology (EULAR 2018) provide insight into molecular changes prior to the onset of arthritis which could inform future novel diagnostics and early therapeutic interventions.

18 Jun 2018

Study finds gender differences in pathophysiology of Parkinson's disease

Not only do women appear to be better protected than men from Parkinson's disease, the associated pathophysiology also shows gender differences. This is a finding of a study from Slovenia, presented at the Congress of the European Academy of Neurology in Lisbon.

18 Jun 2018

Cleveland Clinic receives $3.7 million grant from AHA for atrial fibrillation research

The American Heart Association has awarded Cleveland Clinic a $3.7 million grant for atrial fibrillation research. The four-year, competitive award will support three synergistic projects aimed at improving outcomes for patients with atrial fibrillation, a common heart rhythm abnormality.

13 Jun 2018

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today new positive results from its Phase 1/2 study with lumasiran, an investigational RNAi therapeutic targeting glycolate oxidase for the treatment of Primary Hyperoxaluria Type 1.

8 Jun 2018

International experts agree on need for human-relevant research to improve drug discovery

The average pre-approval cost of research and development for a successful drug is estimated to be US$2.6 billion and the number of new drugs approved per billion US dollars spent has halved roughly every 9 years since 1950.

8 Jun 2018

Classifying heart failure patients based on redox status may help personalize treatment

For more than six decades, oxidative stress has been linked to heart failure, a progressive weakening of the heart muscle that can lead to death. While antioxidant supplements such as vitamin C, vitamin B and beta-carotene have been widely used in heart failure, they often prove ineffective.

6 Jun 2018

Study highlights complexity of the brain’s molecular response to cocaine use

A study in Biological Psychiatry has identified unique genetic changes in the brain's reward circuitry that are associated with cocaine use, including first-time use, withdrawal, and re-exposure to the drug after prolonged withdrawal.

31 May 2018

New study estimates current prevalence of eating disorders in the United States

Biological Psychiatry has published a new study revising the outdated estimates of the prevalence of eating disorders in the United States.

30 May 2018

Brain abnormality linked to general risk for mental illness

A new study by researchers at Duke University reports an abnormality in visual regions of the brain that is associated with a person's general risk for mental illness.

17 May 2018

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

A new study in Biological Psychiatry reports that dementia-related and psychiatric-related proteins cluster together to form aggregates in the brain, leading to abnormal cell function and behavior.

8 May 2018

Greater parent-child communication protects against harmful health behaviors

Children with greater parent communication in early adolescence have less harmful alcohol use and emotional eating in young adulthood, according to a new study in Biological Psychiatry.

3 May 2018

Improving the Diagnosis of Cardiac Sarcoidosis

Cardiac sarcoidosis is an inflammatory disease of the heart that results in various clinical manifestations. Dr Nadera Sweiss discusses her research in the field of sarcoidosis and how diet can influence the diagnosis of the condition.

30 Apr 2018

Flesh eating ulcer cases on the rise in Victoria

Recent reports have shown a rise in cases of flesh eating ulcers in and around Victoria, Australia. Health experts have said that this could become a serious problem if not handled carefully. They have called for funds to deal with this menace. These flesh eating ulcers, according to sources have infected hundreds of individuals in regional Victoria.

16 Apr 2018

Mediterranean-style diet linked to greater gut microbial diversity, lower risk of hospitalization

A diet that is Mediterranean style, and rich in vegetables and fermented milk products such as yoghurt, along with coffee, tea and chocolate, is associated with greater gut microbial diversity and a lower risk of hospitalization in patients with liver cirrhosis, according to the results of an international study presented today at The International Liver Congress™ 2018 in Paris, France.

12 Apr 2018

New blood test may predict future heart disease risk

Despite heart disease and type 2 diabetes being among the leading causes of death in the U.S., the mechanisms leading to and linking these two diseases remain incompletely understood.

10 Apr 2018

Breast cancer survival linked to muscle mass finds study

Researchers have found that women with breast cancer who have a low muscle mass are less likely to survive stage 2 and 3 cancers. The study titled, “Association of Muscle and Adiposity Measured by Computed Tomography with Survival in Patients with Nonmetastatic Breast Cancer,” appears in the latest issue of the journal JAMA Oncology.

9 Apr 2018

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

Allogeneic bone marrow transplant (BMT) is an essential treatment to cure patients with blood cancers such as leukemia. In patients who have undergone chemotherapy and radiation, a small number of cancer cells can remain in the bloodstream and allow the malignancy to recur.

3 Apr 2018

New PET imaging agent could help guide treatments for people with neurological diseases

Researchers have developed a new imaging agent that could help guide and assess treatments for people with various neurological diseases, including Alzheimer's, Parkinson's, and multiple sclerosis.

2 Apr 2018

Pathophysiology News and Research

Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases

Novel chip can be used to identify rhinovirus strains as cause of asthma

Studies provide insight into molecular changes prior to onset of arthritis

Study finds gender differences in pathophysiology of Parkinson's disease

Cleveland Clinic receives $3.7 million grant from AHA for atrial fibrillation research

Alnylam announces new positive results from Phase 1/2 study of lumasiran in patients with PH1

International experts agree on need for human-relevant research to improve drug discovery

Classifying heart failure patients based on redox status may help personalize treatment

Study highlights complexity of the brain’s molecular response to cocaine use

New study estimates current prevalence of eating disorders in the United States

Brain abnormality linked to general risk for mental illness

Study finds new molecular mechanism for neurodegeneration in frontotemporal dementia

Greater parent-child communication protects against harmful health behaviors

Improving the Diagnosis of Cardiac Sarcoidosis

Flesh eating ulcer cases on the rise in Victoria

Mediterranean-style diet linked to greater gut microbial diversity, lower risk of hospitalization

New blood test may predict future heart disease risk

Breast cancer survival linked to muscle mass finds study

Study uncovers mechanism causing chronic GVHD after bone marrow transplant

New PET imaging agent could help guide treatments for people with neurological diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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