Pathophysiology News and Research

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High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Some individuals with anti-Ro/SSA antibodies (anti–Sjögren's-syndrome–related antigen A autoantibodies, also called anti-Ro antibodies) have autoimmune diseases such as lupus or Sjögren's syndrome, but many have no symptoms.

10 Nov 2023

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.

10 Nov 2023

Study links lower testosterone levels with increased arthritis risk

The relationship between serological testosterone levels and arthritis among United States (US) adults.

9 Nov 2023

Charting the future of IBD treatment: From immune modulators to microRNA therapies

In a recent study published in the journal eGastroenterology, researchers delved into the latest therapeutic strategies for managing inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The paper discusses emerging treatments ranging from immune-modulating drugs and biologics to novel approaches like microRNA upregulators and stem cell therapies, highlighting the need for precision medicine in IBD care.

8 Nov 2023

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract.

7 Nov 2023

Study shows depression increases disability risk in rheumatoid arthritis sufferers

The interactions between rheumatoid arthritis (RA) and major depressive disorder (MDD).

7 Nov 2023

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

Comprehensive review unravels the complexities of long COVID, spanning pathophysiology to management strategies, and underscores the need for targeted therapies and early diagnosis.

5 Nov 2023

LMU medical scientists discover new mechanism of alarmin release

LMU medical scientists have demonstrated that important pro-inflammatory mediators are released into the bloodstream through tiny pores in the cell membrane at a very early stage of the immune response.

2 Nov 2023

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

A small clinical trial with a pharmacokinetic sub-study, led by a world-renowned pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for improving functionality in people with acute spinal cord injuries (SCI) if the drug is taken within 12 hours post-injury.

1 Nov 2023

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

A document published in the Canadian Journal of Cardiology outlines the Canadian Cardiovascular Society's classification of acute MI.

1 Nov 2023

Managing menopause: The 2023 toolkit for healthcare practitioners

The authors of the revised 2023 Toolkit extracted key recommendations from professional guidelines and positions as well as consensus statements on menopause and related conditions that have emerged since 2014.

1 Nov 2023

New bedside cardiac assessment curriculum focuses on patient-centered learning

Bedside cardiac assessment (BCA) involves gathering a patient's medical history, performing a physical examination, and determining the need for diagnostic testing.

31 Oct 2023

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

The Canadian Cardiovascular Society (CCS) released the world's first classification of acute myocardial infarction (AMI), or heart attack, based on heart tissue damage research that was driven by two cardiovascular investigators within the Ischemic Heart Disease Program of Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine and Northern Ontario School of Medicine.

30 Oct 2023

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Researchers explore the links between non-dipper hypertension, obstructive sleep apnea (OSA), and Alzheimer's disease (AD). They find that OSA may cause non-dipper hypertension, a condition that exacerbates AD symptoms, but also note that treating OSA can mitigate hypertension and potentially slow AD progression.

29 Oct 2023

Scientists achieve breakthrough in treating 'neglected' polymyalgia rheumatica

Scientists have found success in treating a 'neglected' inflammatory condition, polymyalgia rheumatica, with a drug that could provide an alternative to steroids for patients.

25 Oct 2023

Decoding schizophrenia: insights and impacts from genetic discoveries

A recent study in Molecular Psychiatry delves into the genetic architecture of schizophrenia, uncovering insights into common and rare genetic variants, treatment resistance, and the evolutionary paradox of the disorder. This research highlights the complex nature of schizophrenia and the need for a transdiagnostic approach to psychiatric research.

22 Oct 2023

Linking perinatal events to juvenile idiopathic arthritis-uveitis

Researchers investigate perinatal events associated with the manifestation of juvenile idiopathic arthritis and the development of JIA-uveitis.

20 Oct 2023

Study explores sex-specific effects in Alzheimers disease pathology

The role of biological sex in the development and progression of Alzheimer's Disease (AD).

19 Oct 2023

Lung chip model offers new insights into how radiation damages the lungs

The lung is one of the tissues most sensitive to radiation in the human body. People exposed to high radiation doses following nuclear incidents develop radiation-induced lung injury (RILI), which affects the function of many cell types in the lung, causing acute and sustained inflammation, and in the longer term, the thickening and scarring of lung tissue known as fibrosis.

17 Oct 2023

Are migraines linked to gut health and chronic non-communicable diseases?

The Links Between Migraines, Gut Health, and Chronic Non-Communicable Diseases (CNCDs).

13 Oct 2023

Pathophysiology News and Research

High levels of anti-Ro/SSA antibodies linked to fetal heart block in pregnant women

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

Study links lower testosterone levels with increased arthritis risk

Charting the future of IBD treatment: From immune modulators to microRNA therapies

Novel and emerging therapies offer new hope for patients with inflammatory bowel disease

Study shows depression increases disability risk in rheumatoid arthritis sufferers

Decoding long COVID, pathophysiology, epidemiology, diagnosis, and management

LMU medical scientists discover new mechanism of alarmin release

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

Managing menopause: The 2023 toolkit for healthcare practitioners

New bedside cardiac assessment curriculum focuses on patient-centered learning

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Scientists achieve breakthrough in treating 'neglected' polymyalgia rheumatica

Decoding schizophrenia: insights and impacts from genetic discoveries

Linking perinatal events to juvenile idiopathic arthritis-uveitis

Study explores sex-specific effects in Alzheimers disease pathology

Lung chip model offers new insights into how radiation damages the lungs

Are migraines linked to gut health and chronic non-communicable diseases?

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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