Pathophysiology News and Research

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Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

World-first clinical trial offers new hope in the treatment of mild cognitive impairment among older people

Western Sydney University's NICM Health Research Institute has led a world-first clinical trial in Australia that offers new hope in the treatment of mild cognitive impairment (MCI) among older people.

11 Oct 2023

Presidential advisory by the American Heart Association: connecting cardiovascular, kidney, and metabolic health

The interplay among chronic kidney disease, metabolic risk factors, and the cardiovascular system.

11 Oct 2023

International report paves way for precision diabetes medicine breakthrough

Precision medicine for prevention, diagnosis, treatment, and prognosis for Diabetes.

9 Oct 2023

Can discrimination fuel obesity?

Researchers have identified a potential link between experiences of discrimination and increased obesity risk by examining neural responses to food cues and gut metabolites. The study reveals that discrimination may influence unhealthy food choices, potentially disrupting the brain-gut connection, and suggests brain-targeted treatments or dietary changes as potential interventions.

8 Oct 2023

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity.

4 Oct 2023

How lifestyle tweaks could be the new shield against memory loss: U.S. POINTER study dives in

The U.S. POINTER study aims to explore if lifestyle changes like exercise, diet, and social activities can help preserve cognitive function in older Americans at risk for dementia. Modeled after Finland's successful FINGER study and set to complete in 2025, this extensive research will involve 2,000 participants and focus on diverse and culturally informed strategies.

2 Oct 2023

Examining the cardiac pathology in fatal cases of yellow fever

The characteristics of yellow fever (YF)-related myocardial damage.

28 Sep 2023

Vascular risk factors influence cognitive health differently in men and women with Alzheimer's disease

Researchers utilize imaging findings to elucidate how Alzheimer's dementia can present considerable variations depending on the sex of the individual.

27 Sep 2023

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Researchers explore the role of the CaMKK2 signaling pathway in bipolar disorder, suggesting it as a new treatment target. By targeting this enzyme, scientists aim to develop more effective therapies for bipolar symptoms and metabolic dysfunction.

24 Sep 2023

Brain activity changes predict recovery from early PTSD symptoms

After a traumatic experience, most people recover without incident, but some people - between 2% and 10%- develop posttraumatic stress disorder (PTSD), a mental health condition that can cause debilitating symptoms of anxiety due to emotional dysregulation.

21 Sep 2023

Cognitive-behavioral therapy reduces the interfering effects of fibromyalgia pain

In a recent randomized clinical trial of patients with fibromyalgia, cognitive-behavioral therapy (CBT)-;which uses structured techniques to alter distorted thoughts and negative moods-;was superior to a matched education treatment in reducing the interfering effects of pain and other aspects of fibromyalgia on daily living.

20 Sep 2023

New immunoregulatory protein linked to autoimmune disease

Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained.

18 Sep 2023

Single-cell screening of cerebral organoids to identify developmental defects in autism

Researchers develop CRISPR-human organoids-single-cell RNA sequencing system to identify developmental brain defects in autism.

18 Sep 2023

Reviving reservoirs: new findings shake up HIV treatment understanding

Researchers provide insight into the interaction between T lymphocytes and persisting reservoirs of HIV, with repercussions for harnessing effective, long-lasting responses to HIV eradication.

14 Sep 2023

Early sepsis detection: molecular immune markers show limited impact in screening tools

Researchers evaluated the additional predictive value of molecular immune markers with the Predict Sepsis screening tools developed previously by the same research team.

13 Sep 2023

How COVID-19 targets the pancreas revealed

The study uncovers the role of the PLAC8 protein in making the human pancreas vulnerable to SARS-CoV-2 infection, leading to pancreatic injury and complications in severe COVID-19 cases. The findings open up new avenues for understanding how the virus affects multiple organ systems and offer a potential target for future treatments.

12 Sep 2023

SARS-CoV-2 infection can exacerbate production of auto-antibodies relating to auto-immune diseases

An article published in NPJ Aging, a Springer Nature journal, reveals that natural production of auto-antibodies increases with age and that infection by SARS-CoV-2 can exacerbate production of auto-antibodies relating to auto-immune diseases, helping to explain why aging increases the chances of developing severe COVID-19.

12 Sep 2023

Psoriasis vs. atopic dermatitis: New study reveals surprising inflammatory differences in age-specific groups

The hematological parameters and serum biomarkers of inflammation and immunity in patients with atopic dermatitis and psoriasis.

12 Sep 2023

Pathophysiology News and Research

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

World-first clinical trial offers new hope in the treatment of mild cognitive impairment among older people

Presidential advisory by the American Heart Association: connecting cardiovascular, kidney, and metabolic health

International report paves way for precision diabetes medicine breakthrough

Can discrimination fuel obesity?

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

How lifestyle tweaks could be the new shield against memory loss: U.S. POINTER study dives in

Examining the cardiac pathology in fatal cases of yellow fever

Vascular risk factors influence cognitive health differently in men and women with Alzheimer's disease

New model paves way to understanding and preventing SUDEP in familial epilepsy

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Brain activity changes predict recovery from early PTSD symptoms

Cognitive-behavioral therapy reduces the interfering effects of fibromyalgia pain

New immunoregulatory protein linked to autoimmune disease

Single-cell screening of cerebral organoids to identify developmental defects in autism

Reviving reservoirs: new findings shake up HIV treatment understanding

Early sepsis detection: molecular immune markers show limited impact in screening tools

How COVID-19 targets the pancreas revealed

SARS-CoV-2 infection can exacerbate production of auto-antibodies relating to auto-immune diseases

Psoriasis vs. atopic dermatitis: New study reveals surprising inflammatory differences in age-specific groups

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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