Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.
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When a biologic aortic valve prosthesis fails, the patient often faces a high risk valve replacement through repeat open heart surgery. A new technique, known as Valve-in-Valve, uses minimally invasive techniques to introduce a collapsible aortic heart valve into the damaged valve in order to restore function.
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People who gain weight are more likely to give in to temptations but also are more thoughtful about their actions, according to a new study published in Psychological Science, a journal of the Association for Psychological Science.
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Researchers at Washington University School of Medicine in St. Louis have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread.
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Teenagers who are highly exposed to violent video games—three or more hours per day—show blunted physical and psychological responses to playing a violent game, reports a study in the May issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society.
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Teenagers with high blood pressure appear to have better psychological adjustment and enjoy higher quality of life than those with normal blood pressure, suggests a study in the May issue of Psychosomatic Medicine: Journal of Biobehavioral Medicine, the official journal of the American Psychosomatic Society.
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A major international study involving a Simon Fraser University scientist has found that sequence differences in a gene crucial to the maintenance of our chromosomes' integrity predispose us to certain cancers.
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In a study using mice, researchers from the University of North Carolina at Chapel Hill found that a hormone, adrenomedullin, plays a crucial role in preventing the pregnancy complication preeclampsia.
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A small survey of U.S. obstetrics and gynecology residents finds that fewer than one in five receives formal training in menopause medicine, and that seven in 10 would like to receive it.
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Long after a hangover, a night of bad decisions might take a bigger toll on the body than previously understood. Described in the current issue of Alcoholism: Clinical & Experimental Research, a study at the University of Missouri has revealed a unique connection between binge drinking and the risk for developing alcoholic liver disease and a variety of other health problems.
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Archimedes, Inc., a healthcare modeling and analytics company, announced today that it has begun collaborating with the United States Department of Health and Human Services and Centers for Medicare & Medicaid Services to provide unprecedented access to synthetic CMS claims data.
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A study in The Journal of General Physiology presents new methods to evaluate how astrocytes contribute to brain function, paving the way for future exploration of these important brain cells at unprecedented levels of detail.
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New research out of the George Washington University Cancer Institute focuses on the difficulties of transitioning to adulthood while dealing with the long-term and late effects of cancer and its treatment.
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A collaborative team of physician-scientists at the Medical College of Wisconsin and Children's Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease.
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A study published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, reports that donor mortality is about 1 in 500 donors with living donor liver transplantation (LDLT).
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During fetal development of the mammalian brain, the cerebral cortex undergoes a marked expansion in surface area in some species, which is accommodated by folding of the tissue in species with most expanded neuron numbers and surface area. Researchers have now identified a key regulator of this crucial process.
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RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes - from development to physiology to stress response.
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A fur trader who suffered an accidental gunshot wound in 1822 and the physician who saw this unfortunate incidence as an opportunity for research are key to much of our early knowledge about the workings of the digestive system, say speakers of an upcoming symposium.
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Researchers have discovered that participation in physical activity of at least moderate intensity is more critical to childhood cardiometabolic health than overall sedentary time.
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The 8th Edition of PULMONARY PHYSIOLOGY by Dr. Michael G. Levitzky, Professor of Physiology, Anesthesiology, and Cardiopulmonary Science at LSU Health Sciences Center New Orleans, was published this month by McGraw-Hill in its Lange Physiology Series.
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