Proteome News and Research

RSS

The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.

Microglia show distinct responses under inflammatory conditions

The NorLux Neuro-Oncology Laboratory at LIH's Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches.

26 Nov 2018

Scientists move closer to gonorrhea vaccine after large-scale proteomic study

In a study of proteins historic in its scope, researchers at Oregon State University have pushed closer both to a vaccine for gonorrhea and toward understanding why the bacteria that cause the disease are so good at fending off antimicrobial drugs.

8 Nov 2018

Integral Molecular wins NIH grant to initiate target discovery program for Alzheimer’s disease

Integral Molecular, the industry leader in membrane protein technologies, was awarded a Small Business Innovation Research grant from the NIH to initiate a target discovery program for Alzheimer's disease.

1 Nov 2018

New project aims to deliver fast, effective treatment for autoimmune rheumatic diseases

Affecting around 2 % of the population, autoimmune rheumatic diseases can have severe symptoms, including painful and swollen joints, fever, rashes, fatigue and sensitivity to the sun, with patients needing regular check-ups.

15 Oct 2018

Researchers obtain understanding of pathomechanisms underlying two age-related eye disorders

Population aging is a global phenomenon with profound medical implications. Tissue dysfunction associated with aging affects all vital organs, including the eyes.

3 Oct 2018

Researchers make discovery about yeast metabolism that could help drug developers

Researchers at the Francis Crick Institute have developed machine learning algorithms that can predict the metabolism of yeast based on its protein content.

6 Sep 2018

Research shows proteomics can be used to predict evolution of triple negative breast cancer

The rarest, but also the most aggressive and hard to treat form of breast cancer, is known as triple negative. For this type of cancer, researchers have so far been unable to identify markers that can classify patients by prognosis or probability of responding to different treatments.

29 Aug 2018

Comprehensive analysis reveals weaknesses to target in common pediatric solid tumor

St. Jude Children's Research Hospital investigators have completed the most comprehensive analysis yet of a common pediatric solid tumor, identifying weaknesses to target and a promising precision medicine that is now in clinical trials.

23 Aug 2018

Spanish Flu viruses induce changes in master cellular regulator, shows research

The 1918 "Spanish Flu" was one of the most devastating pandemics in human history, killing 50-100 million people.

22 Aug 2018

Pungent compound contained in ginger ensures fresh breath

The pungent compound 6-gingerol, a constituent of ginger, stimulates an enzyme contained in saliva - an enzyme which breaks down foul-smelling substances.

30 Jul 2018

Simple saliva test could lead to better prediction and prevention of diabetes

Diabetes assessment currently relies on measurement of blood sugar levels -- but a simple saliva sample could replace this, says new research.

23 Jul 2018

New proteomics studies help gain more insights into Alzheimer's, cancer and listeriosis

The brains of people with Alzheimer's disease contain many protein aggregates outside of cells, known as plaques. These are mainly made of the peptide amyloid-beta, which is released from the plasma membrane when the protease BACE1 cleaves its membrane-anchored precursor protein.

19 Jul 2018

Testosterone effective at fighting cachexia in cancer patients, research shows

Many cancer patients suffer from a loss of body mass known as cachexia. Approximately 20 percent of cancer-related deaths are attributed to the syndrome of cachexia, which in cancer patients is often characterized by a rapid and/or severe loss of fat and skeletal muscle.

13 Jul 2018

Bruker launches innovative iProbe HRMAS for biomolecular, materials and clinical research

At EUROMAR 2018 conference (www.euromar2018.org), Bruker announced the iProbe HRMAS, which now enables full automation of high-resolution magic angle spinning NMR.

From Bruker BioSpin - NMR, EPR and Imaging 10 Jul 2018

New studies on molecular and cellular proteomics

Researchers at the Karolinska Institute were using a proteomic screen to determine the mechanism by which cancer drug candidates killed cells when they realized a potential flaw in the standard experimental design.

21 Jun 2018

Researchers use advanced technology to identify proteomes of Th17 and iTreg cells

T helper 17 (Th17) cells belong to a group of T cells with essential functions in autoimmune diseases and inflammation. Regulatory T cells (iTregs) are T cells with a suppressive function to maintain self-tolerance and prevent autoimmune responses.

20 Jun 2018

Study provides insights into how components of different cells in the brain are altered

Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are.

20 Jun 2018

Staying up all night, sleeping all day can swiftly impact over 100 proteins in the blood

Staying awake all night and sleeping all day for just a few days can disrupt levels and time of day patterns of more than 100 proteins in the blood, including those that influence blood sugar, energy metabolism, and immune function, according to new University of Colorado Boulder research published in the journal PNAS this week.

22 May 2018

Study provides insights into how immune cells kill bacteria with acid

The first line of immune defense against invading pathogens like bacteria are macrophages, immune cells that engulf every foreign object that crosses their way. After enclosing it in intracellular membrane vesicles, a process called phagocytosis, macrophages kill their prey with acid.

17 May 2018

Study validates Xpresys Lung 2 for differential diagnosis of early stage lung cancer

Integrated Diagnostics today announced the e-publication of full results of a large prospective clinical trial validating its Xpresys Lung 2 in the peer-reviewed medical journal CHEST¸ the official journal of the American College of Chest Physicians, titled: Assessment of Plasma Proteomics Biomarker’s Ability to Distinguish Benign From Malignant Lung Nodules: Results of the PANOPTIC trial.

12 Mar 2018