Proteomics News and Research

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The term 'proteome' was first coined in 1994, and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.

Difference between human and mouse lung tumor cells explains the discrepancy in cancer drug results

A small but significant metabolic difference between human and mouse lung tumor cells, has been discovered by Weill Cornell Medicine researchers, explaining a discrepancy in previous study results, and pointing toward new strategies for developing cancer treatments.

24 Feb 2023

Study finds protein biomarkers in women with perinatal mood and anxiety disorder symptoms

Cedars-Sinai investigators found that women who developed mood and anxiety disorders associated with pregnancy and childbirth had specific altered proteins circulating in their bloodstream in the third trimester.

23 Feb 2023

When cancer research turns to the immune system – the critical role of peptides and immunopeptidomics

In this interview, AZoM speaks to Rohan Thakur, the President of Life Science Mass Spectrometry at Bruker, about what the opportunities of the market are and how Bruker is planning on rising to the challenge.

From Bruker Life Sciences Mass Spectrometry 22 Feb 2023

Researchers reveal the metabolic reactions upon activating Akt2 enzyme

Takeaki Ozawa and his team from the University of Tokyo reveal the metabolic reactions upon activating an enzyme called Akt2. In doing so, they reveal the inner workings of insulin-regulated metabolism.

21 Feb 2023

In-depth assessment of muscle biopsies in patients with long COVID

Researchers analyzed skeletal muscle biopsies of patients with persistent fatigue and malaise post-exertion to determine the underlying mechanisms of long COVID.

20 Feb 2023

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

15 Feb 2023

New insights into the role of T-cells during long COVID

Researchers characterize the trajectory of long COVID in patients eight months after recovering from infection.

14 Feb 2023

Researchers uncover the cellular basis for sex-specific differences in COVID-19 patients

COVID-19 has had a huge global impact since the initial outbreak in 2019. Men and women show different responses to this disease, with men having a higher risk from infection.

13 Feb 2023

New method provides important insights into the development of epilepsy

In epilepsy research, it has long been assumed that a leaky blood-brain barrier is a cause of inflammation in the brain.

13 Feb 2023

New method for capturing moments during protein translation

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

10 Feb 2023

A machine-learning approach to identify asthma subtypes based on molecular signatures

Researchers determine whether protein expression in nasal fluid samples could assist in the diagnosis of severe asthma subtypes.

31 Jan 2023

Research offers hope for patients affected by rare, hereditary metabolic disease

Methylmalonic aciduria (MMA) is a metabolic disorder that affects approximately one in 90,000 newborns; both parents must carry a genetic predisposition to the disease.

26 Jan 2023

Researchers develop a new multi-omics microsampling method for complete health profiling

Researchers developed a multi-omics-based microsampling workflow for profiling proteins, metabolites, lipids, and specific cytokines and hormones, i.e., multiple analytes, in a single blood sample of 10 μl (microsample).

26 Jan 2023

Scientists reveal how genetic changes lead to differences in the size of cancer cells

Cancer cells can shrink or super-size themselves to survive drug treatment or other challenges within their environment, researchers have discovered.

25 Jan 2023

Study shows SARS-CoV-2 exhibits differential tropism for nasal epithelial cells with age

Researchers explored the relationship between the development of goblet inflammatory cells and the age-related pathophysiology of SARS-CoV-2.

19 Jan 2023

What factors are associated with successful dietary weight loss interventions?

A new study explored the factors governing the success of long- and short-term weight loss interventions.

18 Jan 2023

Study uncovers a new role for Slit2 signaling in stimulating Ewing sarcoma growth

A new research paper was published in Genes & Cancer on December 14, 2022, entitled, "Slit2 signaling stimulates Ewing sarcoma growth."

13 Jan 2023

Evosep receives strategic investment from Novo Holding A/S to accelerate its effort on clinical proteomics

Evosep today announced that Novo Holdings A/S has become a minority shareholder in Evosep Aps with a US$ 40m investment to further Evosep’s technology and application portfolio for clinical proteomics.

From Evosep 10 Jan 2023

New Bruker-Biognosys collaboration aims to deliver advanced proteomics CRO services

Bruker Corporation and Switzerland-based Biognosys AG today announced a strategic partnership, in which Bruker has made a majority-ownership investment in Biognosys. Financial details were not disclosed. J.P.Morgan acted as exclusive financial advisor to Biognosys.

From Bruker BioSpin - NMR, EPR and Imaging 10 Jan 2023

NIH awards eight research grants to advance diagnosis of Multisystem Inflammatory Syndrome in Children

The National Institutes of Health has awarded eight research grants to refine new technologies for early diagnosis of severe illnesses resulting from SARS-CoV-2 infection in children.

9 Jan 2023