Rapamycin News and Research

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Rapamycin is a drug used to prevent the rejection of organ and bone marrow transplants by the body. Rapamycin is an antibiotic that blocks a protein involved in cell division and inhibits the growth and function of certain T cells of the immune system involved in the body's rejection of foreign tissues and organs. It is a type of immunosuppressant and a type of serine/threonine kinase inhibitor. Rapamycin is now called sirolimus.

New, nanotech-based strategy could enable safe, long-term treatment for autoimmune diseases

Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.

1 Dec 2022

Researchers offer new insights into the neurobiological basis of autism spectrum disorders

Findings from a new study published in Cell Reports, involving a collaborative effort between researchers at the Luikart Laboratory at Dartmouth's Geisel School of Medicine and the Weston Laboratory at the University of Vermont, are providing further insight into the neurobiological basis of autism spectrum disorders (ASD) and pointing to possible treatments.

1 Nov 2022

Swine acute diarrhea syndrome coronavirus promotes replication by inducing autophagy

The swine acute diarrhea syndrome coronavirus promotes autophagy to maintain its replication inside host cells.

26 Oct 2022

UArizona researchers discover new protein that is responsible for controlling cell growth in yeasts

Like bacteria, yeasts are found everywhere, even in and around our bodies. And, as with bacteria, you can become infected by yeasts and become ill. Yeasts infect about 150 million people a year and kill about 1.7 million, especially those who are immunocompromised.

28 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Less is more: early short-course rapamycin effective in sustained anti-aging effects

A new study shows that a brief treatment period could have the same anti-aging efficacy and duration of effect but without the potentially serious adverse effects of chronic administration.

1 Sep 2022

The efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell culture

Researchers evaluated the efficacy of honokiol in inhibiting SARS-CoV-2 replication in cell cultures.

2 Aug 2022

Scientists introduce SARS-CoV-2 phenotype screening for identifying novel antiviral drugs

Researchers introduced a phenotypic screening assay for identifying compounds with SARS-CoV-2 inhibition potential based on caspase 3/7 activation.

20 Jul 2022

How does obesity affect the immune system?

A new study summarizes new findings on the immunoregulatory effects of excessive fat stores or malnutrition through Th2 cells.

4 Jul 2022

Oral administration of rapamycin increases β-amyloid buildup in Alzheimer's disease mouse model

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have found that oral administration of rapamycin to an Alzheimer's disease mouse model causes an increase in beta (β)-amyloid protein plaques. β-amyloid buildup is a hallmark of Alzheimer's disease.

7 Jun 2022

A review on the hallmarks of cancer and aging

Dr. Mikhail Blagosklonny published his new review paper in Aging (Aging-US) Volume 14, Issue 9, entitled, "Hallmarks of cancer and hallmarks of aging."

18 May 2022

Novel approach allows islet transplants to survive and control diabetes

In type 1 diabetes, an autoimmune response attacks the pancreas's insulin-producing beta cells, leading to marked fluctuations in blood sugar levels. Lifelong daily insulin treatments are standard for patients, but replacing lost beta cells through transplants of islets, a group of cells in the pancreas, represents an attractive option.

13 May 2022

Artificial proteins as specific and versatile neutralizing binders targeting the spike of SARS-CoV-2

Researchers demonstrated that the biosynthetic proteins called αReps addressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein could be novel SARS-CoV-2 antivirals

13 May 2022

How diet and nutrition impacts lifespan

In a recent study published in the journal Cell, researchers analyzed the association between human longevity to growth and metabolic pathways.

1 May 2022

Researchers uncover a key regulator of pregnancy-associated heart growth

Northwestern Medicine scientists have uncovered a key regulator of pregnancy-associated heart growth, according to a recent study published in the Journal of Clinical Investigation.

18 Apr 2022

The involvement of the skeletal muscles in long COVID-19

Researchers reviewed the mechanisms of muscle tissue injury, aggravating conditions, and associated sequelae in long COVID‐19.

18 Apr 2022

Potential new therapeutic target for pancreatic cancer discovered

Northwestern Medicine investigators have discovered that targeting the G alpha 13 protein in pancreatic tumors promotes tumor growth and progression, according to a study published in Cell Reports.

29 Mar 2022

Insight into oligodendrocytes in the brain could shed light on the causes of neurodegenerative diseases

New research may help scientists locate immature cells in the central nervous system that could shed light on the causes of neurodegenerative diseases like multiple sclerosis-;and autoimmune disease that affects the brain and nervous system-;and allow for the development of better therapeutic treatments.

12 Mar 2022

Diabetes and the mTOR pathway in COVID-19 patients

A new study discusses the possible etiopathogenetic mechanisms associated with diabetes that could enhance the severity of COVID-19.

6 Mar 2022

Study reveals sex-dimorphic immune imprints and in vivo functional impacts of mild COVID-19

Researchers used a systems immunology approach to analyze the immune states of healthy and non-obese subjects who recovered from mild COVID-19 and compared them with age- and sex-matched COVID-19-naive controls.

24 Feb 2022