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Implantable sensor provides advanced warning of kidney transplant failure in rats

An implantable sensor provided advanced warning of kidney transplant failure in rats as much as several weeks earlier than commonly used biomarkers of kidney function, researchers report.

8 Sep 2023

CRISPR/sgRNA-SAM therapy: a potential breakthrough for Parkinson's disease?

Researchers utilize the CRISPR-Cas9 system to induce the synthesis of dopamine (DA) in the brains of a rat model for Parkinson’s disease.

11 Aug 2023

UC San Diego team reports new insights on pelvic floor muscle dysfunction

University of California San Diego researchers are leading a team reporting new insights in Science Translational Medicine on pelvic floor muscle (PFM) dysfunction, which is one of the key risk factors for pelvic floor disorders which impact close to a quarter of women in the U.S.

2 Aug 2023

Biomimetic materials pulsed with low-energy blue light can reshape damaged corneas

An injectable biomaterial activated by pulses of low-energy blue light has tremendous potential for on-the-spot repair to the domed outer layer of the eye, a team of University of Ottawa researchers and their collaborators have revealed.

26 Jul 2023

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Insomnia drug shows potential as an effective treatment for opioid use disorder

The insomnia drug suvorexant (Belsomra) might be an effective treatment for opioid use disorder, according to a preclinical study from Scripps Research.

27 Apr 2023

Maternal and early-life exposure to high amounts of fat induce salty taste preference in offspring

We are all aware of the importance of eating healthy food, especially during pregnancy. A high-fat diet has dramatic consequences on the metabolism.

24 Apr 2023

Proper nutrition could boost recovery from traumatic brain injury

In the first few days after a traumatic brain injury (TBI), food is often an afterthought as clinicians focus on minimizing the damage to the brain.

21 Apr 2023

Diabetes drug may help recover from short periods of severe food insecurity or anorexia

New research results suggest that the widely used diabetes drug metformin may be beneficial for recovering from short periods of severe food insecurity or anorexia.

21 Apr 2023

Study sheds light on cardiovascular health of babies exposed to opioids in the womb

A new study sheds light on an understudied aspect of today's opioid crisis: What happens to the cardiovascular health of babies exposed to opioids in the womb.

13 Apr 2023

What is the effect of maternal obesity on the brain development of offspring?

Recently, scientists reviewed the mechanisms associated with the maternal microbiome, breast milk composition, maternal and placental metabolites, altered maternal care, and inflammation, which influences the brain development of the offspring.

22 Mar 2023

Intermittent fasting's impact on bone health

Although several studies have indicated intermittent fasting (IF) promotes weight loss and improves metabolic health, its effect on bone health is unclear. Recently, scientists reviewed existing literature and summarized the effect of varied forms of IF, such as the 5:2 diet, alternate day fasting (ADF), and time-restricted eating/feeding (TRE/TRF), on bone health. This review is available in the British Journal of Nutrition.

7 Mar 2023

Injectable hydrogel composite loaded with stem cells shows success in treating perianal fistulas

In a new study using a rat model of Crohn's disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown significant success in treating perianal fistulas (PAF) — one of the many complications of Crohn's disease.

25 Jan 2023

Yale researchers identify neuronal basis of impaired consciousness in children with absence epilepsy

Imagine slipping in and out of consciousness hundreds of times per day, staying awake the whole time but having no sense of awareness during these lapses.

10 Jan 2023

HU begins human trial for promising treatment to reverse paralysis and language disorder after stroke

Hiroshima University started the human trial for a promising treatment that offers hope in potentially reversing paralysis and language disorder after moderate to severe stroke using therapeutically superior mesenchymal stem cells (MSCs) derived from the cranial bone.

1 Dec 2022

Rehabilitation plus stem cell grafting after spinal cord injury can augment functional outcomes

In recent years, researchers have made measurable progress, using animal models, to promote tissue regeneration in spinal cord injuries (SCI) through implanted neural stem cells or grafts. Other efforts have shown that intensive physical rehabilitation can improve function after SCI by promoting greater or new roles for undamaged or spared cells and neural circuits.

28 Oct 2022

New studies point to a broadly applicable treatment for neurodegenerative diseases

Two new studies from Washington University School of Medicine in St. Louis support development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that serves as the central executioner in the death of axons, the wiring of the nervous system.

26 Oct 2022

Potent antibiotic-loaded bone-cement could be used to treat bone infections

Each year, 700,000 people die due to antibiotic resistance. A growing global population unfortunately generates a growing resistance to established antibiotic treatments -; a threat that has been met with insufficient funding and dwindling inspiration, as commercial incentives for developing new antibiotics have fallen.

13 Oct 2022

OU researcher may have found a way to reduce the number of TBI surgeries to just one

A battered woman. A wounded warrior. A football player. All from completely different worlds. Yet, all are connected by one thing – traumatic brain injury.

20 Sep 2022

Excessive smartphone use may lead to early puberty

Exposure to blue light via regular use of tablets and smartphones may alter hormone levels and increase the risk of earlier puberty, according to data from a rat study presented today at the 60th Annual European Society for Paediatric Endocrinology Meeting.

16 Sep 2022