Respiratory News and Research

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Chemicals found in common household products increase asthma risk

Commonly-used household products should carry a warning that they increase the risk of asthma, according to a new evidence review.

12 Jul 2021

Review of scientific evidence supports zoonotic origin for SARS-CoV-2 with zero biological evidence for laboratory leak scenario

Recently, an international team of biologists, led by professors from the University of Sydney and the University of Edinburgh, critically reviewed currently available scientific evidence that may throw some light on the origin of the virus that causes COVID-19.

12 Jul 2021

Scientists identify novel entry receptors for SARS-CoV-2

Scientists from the Northeastern University, China, and University of Michigan, USA, have recently identified five potential entry receptors for SARS-CoV-2. These receptors specifically express in SARS-CoV-2-infected cells and have a high binding affinity for the viral spike protein.

12 Jul 2021

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Scientists from the US and Germany have recently evaluated the efficacy of an mRNA-based COVID-19 vaccine candidate, CV07050101, in inducing humoral and cellular immune responses in non-human primates. The study reveals that prime-boost immunization with the vaccine candidate induces only limited immunity against SARS-CoV-2.

12 Jul 2021

Composition and structure of nasopharyngeal microbiome relate to COVID-19 disease severity

Breathing treatments are provided to hospitalized COVID-19 patients. In this study, the researchers examined the community composition in relation to three attributes - COVID-19 status, breathing assistance, and antibiotic use. This study is published in the journal, Applied Microbiology.

12 Jul 2021

What is behind the inconsistent results of COVID-19 clinical trials?

“Most clinical studies of antiviral drugs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have failed to observe a statistically significant effect, which may be due to poor designs of clinical trials.”

12 Jul 2021

SARS-CoV-2 mRNA vaccine efficacy reduced in patients with CD20-B-cell depleting treatment history

Researchers from Switzerland recently investigated humoral and cell-mediated immune responses to mRNA-based vaccines in patients undergoing treatment with CD20-B-cell depleting agents for autoimmune diseases, transplantation, or malignancy.

12 Jul 2021

Socioeconomic inequities and structural racism are neglected pieces of SARS-CoV-2 transmission networks

A recent perspective article published in the prestigious journal Science highlights how the use of network-driven strategies for adequately informing rapidly emergent epidemic responses is not only evidence-based but also an equitable way forward for the current coronavirus disease (COVID-19) pandemic and future respiratory pandemics.

12 Jul 2021

Accelerating the design of minibinder therapeutics resilient to SARS-CoV-2 mutations

Multivalent protein-based minibinders hold great promise as potential prophylactic and treatment agents, as they can retain their activity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. This was revealed in a recent tour-de-force research study currently available on the bioRxiv* preprint server while the article undergoes the peer review process.

11 Jul 2021

Pfizer aims to implement boosters and a new vaccine based on SARS-CoV-2 Delta variant

The drugmaker Pfizer, one of the companies behind the Pfizer-BioNTech vaccine, or BNT162b2, awaits the green light to develop a COVID-19 booster shot that can protect against emerging variants. Pfizer’s COVID-19 vaccine has been shown to be 95% effective in an ongoing large-scale clinical trial against the original SARS-CoV-2 strain.

11 Jul 2021

Pfizer-BioNTech’s COVID-19 vaccine effective and safe for use among cancer patients

Researchers in Israel have conducted a study showing that the use of Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine appears to be safe and effective among patients with cancer.

11 Jul 2021

Novel monoclonal antibody could pave way for future COVID-19 treatments and vaccines

Researchers in the United States have shown that targeting the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike protein could achieve broad neutralization of variants of concern.

11 Jul 2021

SARS-CoV-2 immunity due to prior infection or vaccination is similar, study says

A new study finds that the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection is low following one episode of the infection.

11 Jul 2021

Antigen testing identifies PCR-positive children with live SARS-CoV-2

A recent study finds that antigen-based testing can reliably identify children who are infectious for SARS-CoV-2.

11 Jul 2021

Initial SARS-CoV-2 vaccination response may predict BNT162b2 booster response, but not AZD1222

A new study finds that the antibody titer values prior to the booster dose of the BNT162b2 vaccine can predict the final antibody response after two doses.

11 Jul 2021

Study examines SARS-CoV-2's inactivation across a range of UVC wavelengths

A recent study published on the preprint server medRxiv* describes the disinfection of SARS-CoV-2 using UVC irradiation at different wavelengths.

11 Jul 2021

Can saliva metabolomics predict COVID-19 severity?

New research suggests that saliva metabolomics may be able to help prognosticate disease severity in COVID-19 positive individuals.

9 Jul 2021

Antiviral activity of long-chain polyphosphates against SARS-CoV-2 infection

A new study has been published in Science Signaling that has examined the potential role that long-chain inorganic polyphosphates (polyPs) play against SARS-CoV-2 infection.

9 Jul 2021

New York City SARS-CoV-2 breakthrough cases predominantly Alpha and Iota variants

While Delta (B.1.617.2) has overtaken Alpha (B.1.1.7) as the dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant in the United States, Alpha remained a force to be reckoned with in New York City earlier this year. New research published on the preprint medRxiv* server details breakthrough infections in vaccinated and unvaccinated individuals living in New York City.

9 Jul 2021

Researchers model probability of extinction of SARS-CoV-2 variant in an outbreak

However, it cannot be confirmed for certain that the strain has been eliminated, raising the question of how long a strain must go undetected before being considered, in all probability, extinct.

9 Jul 2021

Respiratory News and Research

Chemicals found in common household products increase asthma risk

Review of scientific evidence supports zoonotic origin for SARS-CoV-2 with zero biological evidence for laboratory leak scenario

Scientists identify novel entry receptors for SARS-CoV-2

mRNA-based COVID-19 vaccine CV07050101 demonstrates limited immunogenicity in non-human primates

Composition and structure of nasopharyngeal microbiome relate to COVID-19 disease severity

What is behind the inconsistent results of COVID-19 clinical trials?

SARS-CoV-2 mRNA vaccine efficacy reduced in patients with CD20-B-cell depleting treatment history

Socioeconomic inequities and structural racism are neglected pieces of SARS-CoV-2 transmission networks

Accelerating the design of minibinder therapeutics resilient to SARS-CoV-2 mutations

Pfizer aims to implement boosters and a new vaccine based on SARS-CoV-2 Delta variant

Pfizer-BioNTech’s COVID-19 vaccine effective and safe for use among cancer patients

Novel monoclonal antibody could pave way for future COVID-19 treatments and vaccines

SARS-CoV-2 immunity due to prior infection or vaccination is similar, study says

Antigen testing identifies PCR-positive children with live SARS-CoV-2

Initial SARS-CoV-2 vaccination response may predict BNT162b2 booster response, but not AZD1222

Study examines SARS-CoV-2's inactivation across a range of UVC wavelengths

Can saliva metabolomics predict COVID-19 severity?

Antiviral activity of long-chain polyphosphates against SARS-CoV-2 infection

New York City SARS-CoV-2 breakthrough cases predominantly Alpha and Iota variants

Researchers model probability of extinction of SARS-CoV-2 variant in an outbreak

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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