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MSU researchers discover cause of death in children who get malaria

MSU researchers discover cause of death in children who get malaria

Researchers from Michigan State University have uncovered the cause of death in children who die from cerebral malaria. [More]
Study compares HA injections and triamcinolone in improving pain in patients with lumbar ZJT arthropathy

Study compares HA injections and triamcinolone in improving pain in patients with lumbar ZJT arthropathy

A study presented at AAP 2015 San Antonio compares the effectiveness of HA injections to triamcinolone in improving pain and function in patients with lumbar ZJT arthropathy. [More]
Medicine-loaded nanoparticles could help patients achieve corneal transplant success

Medicine-loaded nanoparticles could help patients achieve corneal transplant success

There are about 48,000 corneal transplants done each year in the U.S., compared to approximately 16,000 kidney transplants and 2,100 heart transplants. Out of the 48,000 corneal transplants done, 10 percent of them end up in rejection, largely due to poor medication compliance. This costs the health care system and puts undue strain on clinicians, patients and their families. [More]
Glucocorticoid therapies promote functional recovery of blood-brain barrier after blast injury

Glucocorticoid therapies promote functional recovery of blood-brain barrier after blast injury

Barclay Morrison III, associate professor of biomedical engineering at Columbia Engineering, has led the first study to determine underlying biological mechanisms that promote functional recovery of the blood-brain barrier (BBB) after blast injury. The research demonstrates that treatment with the glucocorticoid, dexamethasone, after primary blast injury promotes rapid recovery of an in vitro model of the BBB, a highly restrictive semi-permeable barrier whose primary function is to maintain the brain's microenvironment and protect it from potentially toxic substances. [More]
BPA exposure may cause tooth enamel abnormality in children

BPA exposure may cause tooth enamel abnormality in children

A tooth enamel abnormality in children, molar incisor hypomineralization (MIH), may result from exposure to the industrial chemical bisphenol A (BPA), authors of a new study conclude after finding similar damage to the dental enamel of rats that received BPA. [More]
Vitamin D, omega-3 fatty acids may optimize brain serotonin concentrations and function

Vitamin D, omega-3 fatty acids may optimize brain serotonin concentrations and function

Although essential marine omega-3 fatty acids and vitamin D have been shown to improve cognitive function and behavior in the context of certain brain disorders, the underlying mechanism has been unclear. In a new paper published in FASEB Journal by Rhonda Patrick, PhD and Bruce Ames, PhD of Children's Hospital Oakland Research Institute, serotonin is explained as the possible missing link tying together why vitamin D and marine omega-3 fatty acids might ameliorate the symptoms associated with a broad array of brain disorders. [More]
Researchers reveal that mosquitoes’ sexual biology may key to malaria transmission

Researchers reveal that mosquitoes’ sexual biology may key to malaria transmission

Sexual biology may be the key to uncovering why Anopheles mosquitoes are unique in their ability to transmit malaria to humans, according to researchers at Harvard T. H. Chan School of Public Health and University of Perugia, Italy. [More]
Virus that causes chicken pox and shingles linked to giant cell arteritis

Virus that causes chicken pox and shingles linked to giant cell arteritis

A new study developed at the University of Colorado School of Medicine at the Anschutz Medical Campus links the virus that causes chicken pox and shingles to a condition that inflames blood vessels on the temples and scalp in the elderly, called giant cell arteritis. [More]
New study links chicken pox and shingles virus to giant cell arteritis in elderly

New study links chicken pox and shingles virus to giant cell arteritis in elderly

A new study links the virus that causes chicken pox and shingles to a condition that inflames blood vessels on the temples and scalp in the elderly, called giant cell arteritis. The study is published in the February 18, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. The condition can cause sudden blindness or stroke and can be life-threatening. [More]
Experts provide suggestions to prevent neurological injuries associated with epidural steroid injections

Experts provide suggestions to prevent neurological injuries associated with epidural steroid injections

Epidural steroid injections are commonly used to treat pain; however, they can in rare situations produce life-threatening neurological injuries such as stroke and paralysis. In the Online First edition of February's Anesthesiology, the official medical journal of the American Society of Anesthesiologists, a panel of experts representing 13 national medical organizations provided 17 suggestions aimed at preventing such injuries and improving patient safety. [More]
Health Canada to review Cipher’s self-adhesive medicated plaster, Beteflam Patch

Health Canada to review Cipher’s self-adhesive medicated plaster, Beteflam Patch

Cipher Pharmaceuticals Inc. (NASDAQ: CPHR; TSX:CPH) ("Cipher" or "the Company") today announced that the Beteflam Patch (previously called the Betesil® Patch) has been accepted for review by Health Canada. [More]
Steroid use associated with five-fold increase of blood clots in IBD patients

Steroid use associated with five-fold increase of blood clots in IBD patients

Compared with biologic therapy, corticosteroid (steroid) use is associated with a nearly five-fold increase of venous thromboembolism in inflammatory bowel disease (IBD) patients, according to a new study1 in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. [More]
Research reveals key protein structure, paves way for better anti-anxiety drugs

Research reveals key protein structure, paves way for better anti-anxiety drugs

When new medicines are invented, the drug may hit the intended target and nullify the symptoms, but nailing a bull's eye - one that produces zero side effects - can be quite elusive. [More]
Study finds no evidence that testosterone replacement therapy increases cardiovascular risk

Study finds no evidence that testosterone replacement therapy increases cardiovascular risk

Fears of a link between testosterone replacement therapy and cardiovascular risk are misplaced, according to a review published in this month's Mayo Clinic Proceedings. The therapy has come under widespread scrutiny in recent months, including by a federal Food and Drug Administration panel convened last fall. [More]
Gedeon Richter, Actavis report positive top line results from cariprazine Phase III trial

Gedeon Richter, Actavis report positive top line results from cariprazine Phase III trial

Gedeon Richter Plc. and Actavis plc today announced positive results from a Phase III trial evaluating the efficacy and safety of cariprazine in the prevention of relapse in patients with schizophrenia. [More]
FDA grants orphan drug status to NBI-77860 for treatment of congenital adrenal hyperplasia

FDA grants orphan drug status to NBI-77860 for treatment of congenital adrenal hyperplasia

Neurocrine Biosciences, Inc. announced today that NBI-77860, a proprietary corticotropin releasing factor 1 (CRF) receptor antagonist, has been granted orphan drug status by the United States Food and Drug Administration (FDA) for the treatment of congenital adrenal hyperplasia (CAH) a disease that affects approximately 20,000-30,000 people in the United States. [More]
Fast HPLC screening methods used to detect steroids

Fast HPLC screening methods used to detect steroids

As the importance of steroids in the regulation of bioprocesses has increased so has the demand for fast screening methods for their detection. HPLC is a highly regarded analytical technique for pharmaceutical applications due to its unrivalled analytical validation characteristics; including accuracy, precision, limit of detection, specificity, linearity and range, and ruggedness. [More]
GSU researchers discover how steroids use a novel 'trick' to suppress inflammation

GSU researchers discover how steroids use a novel 'trick' to suppress inflammation

A new "trick" steroids use to suppress inflammation, which could be used to make new anti-inflammatory drugs without the harmful side effects of steroids, has been discovered by researchers at Georgia State University. [More]
FDA receives Actavis' NDA resubmission for cariprazine

FDA receives Actavis' NDA resubmission for cariprazine

Actavis plc (NYSE: ACT) and Gedeon Richter Plc. today announced that the U.S. Food and Drug Administration (FDA) has acknowledged receipt of Actavis' New Drug Application (NDA) resubmission for its atypical antipsychotic cariprazine, a potent dopamine D3/D2 receptor partial agonist with preferential binding to D3 receptors. [More]
Palatin begins bremelanotide phase 3 study for treatment of female sexual dysfunction

Palatin begins bremelanotide phase 3 study for treatment of female sexual dysfunction

Palatin Technologies, Inc., a biopharmaceutical company developing targeted, receptor-specific peptide therapeutics for the treatment of diseases with significant unmet medical needs and commercial potential, today announced that it has started its bremelanotide pivotal registration program. [More]
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