Toxoplasmosis News and Research

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Toxoplasmosis is considered to be the third leading cause of death attributed to foodborne illness in the United States. More than 60 million men, women, and children in the U.S. carry the Toxoplasma parasite, but very few have symptoms because the immune system usually keeps the parasite from causing illness. However, women newly infected with Toxoplasma during pregnancy and anyone with a compromised immune system should be aware that toxoplasmosis can have severe consequences for them.

Scientists pinpoint immune-system targets in complex pathogens

Our immune cells have an amazingly intricate recognition system to detect invading pathogens. Often, the intricacies have overwhelmed scientists who want to know exactly what gives an alarm signal to T cells, a class of white blood cells that recognizes invaders.

7 Dec 2008

Parasites that live inside cells use loophole to thwart immune system

St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide.

4 Nov 2008

Parasites that live inside cells use loophole to thwart immune system

St. Jude Children's Research Hospital scientists have discovered a mechanism by which intracellular pathogens can shut down one of the body's key chemical weapons against them: nitric oxide. The researchers found that the microbes block nitric oxide production by subverting the biochemical machinery used by immune cells called macrophages to produce the chemical.

3 Nov 2008

Persistent bacterial infection exploits killing machinery of immune cells

A new study reveals an important and newly discovered pathway used by disease-causing bacteria to evade the host immune system and survive and grow within the very cells meant to destroy them. This discovery may lead to new treatments and vaccines for tuberculosis (TB) and certain other chronic bacterial and parasitic infections.

3 Nov 2008

Discovery of new pathway used by disease-causing bacteria to evade host immune system and survive

2 Nov 2008

Discovery of potential key to better drugs to fight Toxoplasmosis parasite

Discoveries by IU School of Medicine scientists have opened a promising door to new drugs for toxoplasmosis and other parasites that now can evade treatments by turning dormant in the body.

19 Jun 2008

Misoprostol off-label use may have led to deaths

Preliminary U-M studies indicate that oral use of RU-486's companion drug misoprostol is safe, but vaginal use may undermine body's immune responses

16 Jun 2008

New malaria drug also treats toxoplasmosis

A new drug that will soon enter clinical trials for treatment of malaria also appears to be 10 times more effective than the key medicine in the current gold-standard treatment for toxoplasmosis, a disease caused by a related parasite that infects nearly one-third of all humans—more than two billion people worldwide.

6 Mar 2008

Blocking parasites' communication reduces infection

One of the most common human parasites, Toxoplasma gondii, uses a hormone lifted from the plant world to decide when to increase its numbers and when to remain dormant, researchers at Washington University School of Medicine in St. Louis have found.

10 Jan 2008

Hospitalizations for children with HIV drop by nearly two thirds

The number of infants under age 2 with HIV who were hospitalized fell by 64 percent between 1998 and 2005, according to the latest News and Numbers by the Agency for Healthcare Research and Quality.

18 Dec 2007

New guideline recommends when to use CT scans in ER for seizures

A guideline developed by the American Academy of Neurology recommends immediate brain CT scans to screen certain emergency room patients with seizures.

29 Oct 2007

Toxoplasmosis infection trick revealed by scientists

Toxoplasmosis is a parasitic disease, primarily carried by cats.

11 May 2007

Toxoplasma may be affecting human behavior on a mass scale

A common parasite found in cats may be affecting human behavior on a mass scale, according to a scientist based at the University of California, Santa Barbara.

3 Aug 2006

Full year of treatment with pyrimethamine and sulfadiazine helps infants and children with toxoplasmosis

The first long-term study shows that treatment with pyrimethamine and sulfadiazine (two anti-parasitic drugs) during the first year of life leads to a lasting reduction in brain and eye damage for children with congenital toxoplasmosis.

16 May 2006

Link between cat faeces and schizophrenia

Researchers have found stronger evidence for a link between a parasite in cat faeces and undercooked meat and an increased risk of schizophrenia.

18 Jan 2006

Evidence is mounting to link toxoplasmosis with schizophrenia

Keep pet cats inside, stop feeding strays, cook meat sufficiently and reconsider the way the veterinary profession and public health agencies think - and teach - about the zoonotic pathogen Toxoplasma gondii.

18 Oct 2005

Association between maternal exposure to toxoplasmosis and increased risk for developing schizophrenia

Toxoplasmosis is a parasitic infection that can develop from eating undercooked meat and unwashed fruits and vegetables, drinking contaminated water, or not washing one's hands after gardening or changing cat litter boxes. Researchers found a potential link between high maternal toxoplasmosis gondii antibody titers and development of schizophrenia spectrum disorders in the adult offspring.

16 May 2005

Screening for toxoplasmosis for all pregnant women and newborns is necessary

Physicians found that signs, symptoms and identifiable risk factors are absent in more than half of the mothers of infants with congenital toxoplasmosis in a national study of children with this disease.

9 Feb 2005

76 million people get sick in US, 300,000 are hospitalized, and 5,000 die from foodborne illness

Foodborne illnesses have a major public health impact in the United States. It is estimated that each year in the United States, 76 million people get sick, more than 300,000 are hospitalized, and 5,000 die as a result of foodborne illnesses, primarily the very young, elderly, and the immunocompromised.

18 Apr 2004

Cryptosporidium parvum parasite could help to develope new therapies for the disease

Cryptosporidium parvum, an insidious, one-celled, waterborne parasite that lodges in the intestines of infected people and animals and for which there is currently no effective treatment, is missing key structures normally found in similar parasites, say researchers supported by the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. The results of their genome sequencing project, could help scientists home in on new drug targets that may lead to therapies for the disease.

26 Mar 2004