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Hox genes control stem cells involved in forming and repairing bone

Genes long known to control the formation of bones before birth also control bone healing later in life, a new study found.

20 Mar 2023

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

15 Mar 2023

Important backup mechanism of human immune cells elucidated

The enzyme TBK1 is an important component of the innate immune system that plays a critical role in the defense against viruses.

10 Mar 2023

First fully human ovarian organoids provide insights about female reproductive health and disease

Despite the fact that we all start out as an egg cell in one of our mother's ovaries, these human reproductive organs are surprisingly under-studied.

21 Feb 2023

Pluripotent stem cells can be a limitless source of transplantable HSPCs

Cells in the blood such as immune cells, red blood cells and other vital cell types are constantly renewed from stem cells, the so-called hematopoietic stem and progenitor cells (HSPCs).

19 Feb 2023

Brain cells may age faster in people with cocaine use disorder

A new study finds evidence from the DNA methylome that the biological age – different from the chronological age – of cells in Brodmann Area 9 of the prefrontal cortex might be greater in people with cocaine use disorder.

16 Feb 2023

Cocaine use disorder leads to changes in the 'methylome' of a brain region

Scientists tend to view substance addiction as primarily a disease of the brain. When we enjoy sex, food, music, or hobbies, regions of our brain within the reward pathway are flooded with pleasure-inducing dopamine.

14 Feb 2023

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

New research may explain why some patients suffer from long-COVID

A review article published in The Journal of Clinical Investigation deciphers the relationship between rare inborn errors of type I interferon immunity and the development of severe coronavirus disease 2019 (COVID-19) pneumonia.

6 Feb 2023

AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off.

26 Jan 2023

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, "The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans."

25 Jan 2023

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

A study published in the journal PNAS reveals that the gut microbiome stabilizes the synchronization between gut and brain circadian rhythms.

24 Jan 2023

Several genes and individual genetic variations associated with atrial fibrillation discovered

In the largest genetic study of heart arrhythmia to date, researchers led by Kazuo Miyazawa and Kaoru Ito at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan report the discovery of several genes and individual genetic variations that are associated with atrial fibrillation.

19 Jan 2023

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Researchers performed age-reversing experiments, in vivo and in vitro, in progeroid mice using gene therapy.

19 Jan 2023

Research explores the utility of epigenetically predicted BMI

DNA methylation is an accurate predictor of current BMI and a poor predictor of future BMI.

18 Jan 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Transcription Factors News and Research

Hox genes control stem cells involved in forming and repairing bone

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Important backup mechanism of human immune cells elucidated

First fully human ovarian organoids provide insights about female reproductive health and disease

Pluripotent stem cells can be a limitless source of transplantable HSPCs

Brain cells may age faster in people with cocaine use disorder

Cocaine use disorder leads to changes in the 'methylome' of a brain region

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

New research may explain why some patients suffer from long-COVID

AI tool promises to accelerate the development of gene therapies on a large scale

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

Several genes and individual genetic variations associated with atrial fibrillation discovered

Partial genetic reprogramming might extend lifespan and reverse aging in old mice

Research explores the utility of epigenetically predicted BMI

Combination of multiple maps uncovers new genetic risk factor for AMD

Can diets reverse or delay aging?

How do fruit, whole grains, and trout-based dietary interventions impact obesity management?

The relationship between metabolic disease and alternations in lipid homeostasis

Researchers discover new role of small RNAs in Salmonella infections

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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