Transplant News and Research

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Lab made urinary tube going strong after six years of transplant

In a scientific breakthrough, five boys who were unable to urinate due to pelvic injury were cured for up to six years after getting new lab-grown urethras or urinary tubes that connect with the bladder. This breakthrough comes from Wake Forest University researcher Anthony Atala. It was in 2006 that the team reported the first successful implantation of lab-grown urinary bladders into humans. Today six years after the operation all of the boys continue to do well, with normal or near-normal urinary flow. The boy first treated is now 16 years old and received his lab-grown urethra over six years ago.

8 Mar 2011

Researchers develop new method for DNA sequencing analysis

Up to today, researchers have been limited to running just a few DNA samples at a time, at a cost of SEK 100,000 per run. Now researchers at the Royal Institute of Technology in Stockholm have hit upon a new method that allows 5,000 samples to be run at the same time and at the same price.

8 Mar 2011

First western U.S. hand transplant surgery performed at UCLA Medical Center

Surgeons at Ronald Reagan UCLA Medical Center performed the first hand transplant in the western United States in an operation that began one minute before midnight on Friday, March 4, and was completed 14-and-a-half hours later, on Saturday, March 5.

8 Mar 2011

hUCBs and MenSCs transplant may offer future therapeutic benefit for AD, stroke, ALS

Transplanting stem cells derived from umbilical cord blood cells and menstrual blood cells may offer future therapeutic benefit for those suffering from stroke, Alzheimer's disease, and amyotrophic lateral sclerosis, says a team of neuroscience researchers from the University of South Florida's Department of Neurosurgery and Brain Repair and collaborators from three private-sector research groups, Saneron CCEL Therapeutics, Inc., Tampa, FL, Cryo-Cell International, Inc., Oldsmar, FL, and Cryopraxis, Cell Praxis, BioRio, Rio de Janeiro, Brazil.

8 Mar 2011

State roundup: Mass. effort to manage care for chronically ill; promoting organ donations

For a glimpse of the future of Massachusetts health care as Gov. Deval Patrick envisions it, consider Phyllis Minsky. At 82, Phyllis is complex. Medically, that is. ... Older patients with multiple chronic diseases are the biggest consumers of health care; some 15 percent of Medicare patients make up over 75 percent of health care spending.

8 Mar 2011

First implantable heart transplant using new LVAD performed at University of Utah Hospital

Surgeons at University of Utah Hospital have performed the hospital's first implant of a new-generation left ventricular assist device using the HeartWare HVAD. The tiny, partial artificial heart device is being used as part of a national research study for patients with advanced heart failure who are not candidates for heart transplantation.

5 Mar 2011

Pfizer's ORAL Sync Phase 3 study of tofacitinib in moderate-to-severe RA meets primary endpoints

Pfizer Inc. today announced that the ORAL Sync Phase 3 study of tofacitinib, formerly known as tasocitinib, an investigational, novel, oral JAK inhibitor, being studied in moderate-to-severe rheumatoid arthritis, met its primary endpoints by showing statistically significant changes versus placebo in reducing signs and symptoms of RA, as measured by ACR20 response rates at six months; in improving physical function, as measured by mean change in HAQ DI at three months; and in reaching DAS28-4 <2.6 at six months.

5 Mar 2011

Viewpoints: Gambling on entitlement cuts; 'culture war' over family planning; insurance premium 'gouge' in Calif.

The House Republicans are rolling the political dice. They've pledged that in their budget for next year they will offer detailed proposals for curbing spending on "entitlements" — Social Security, Medicare and Medicaid. When Democrats heard this, their world suddenly brightened. One congressional aide dismissed the Republicans as "suckers".

4 Mar 2011

ThermoGenesis prices offering of 2,250,000 shares of common stock

ThermoGenesis Corp., a leading supplier of innovative products and services that process and store adult stem cells, said today that it has determined the pricing for an offering of shares and warrants.

4 Mar 2011

Sangamo's preclinical ZFN-gene modification studies for HIV/AIDS treatment presented at CROI

Sangamo BioSciences, Inc. announced that data from its programs to develop ZFN-based therapeutic approaches for the treatment of HIV/AIDS were discussed in four oral presentations at the 18th Conference on Retroviruses and Opportunistic Infections, held in Boston from February 27 to March 2, 2011.

4 Mar 2011

Low physical activity increases kidney transplant patients' likelihood of dying early

Low physical activity increases kidney transplant patients' likelihood of dying early, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology. The results suggest that patients need to exercise to fend off an early death.

4 Mar 2011

First artificial bronchus graft in a lung cancer patient successful

In a medical breakthrough French surgeons have grafted an artificial airway to save a lung afflicted by bronchial cancer in a 78-year-old man. The bronchi are the main tubes or airways used for taking air from the trachea to the two sides of the lung.

3 Mar 2011

Racial and ethnic groups less likely to receive kidney transplants than others

Not all racial and ethnic groups have equal access to kidney transplantation, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology. The results indicate that the reasons for these disparities are varied and that more focused efforts are needed to address them.

3 Mar 2011

Organ transplant deaths investigated

Three women died within one week of each other after they received diseased organs in transplant procedures at the Austin and Royal Melbourne hospitals according to an ongoing inquest.

3 Mar 2011

Vical receives EMA Scientific Advice for Phase 3 trial of TransVax therapeutic CMV vaccine

Vical Incorporated announced today the receipt of Scientific Advice from the European Medicines Agency (EMA) recommending practical efficacy endpoints for a Phase 3 trial of the company's TransVax™ therapeutic cytomegalovirus (CMV) vaccine.

3 Mar 2011

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

3 Mar 2011

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a marker for severe HCV-induced graft inflammation, as well as a predictor for unsuccessful treatment. Study findings—the largest to report on the role IL28B variants in a transplant cohort with recurrent HCV—are published in the March issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases.

2 Mar 2011

Mathematical model predicts lifespan of stem cells

When patients receive a bone marrow transplant, they are getting a new population of hematopoietic stem cells. Fresh stem cells are needed when a patient is low on red blood cells, as in anemia, or white blood cells, which can be caused by cancer or even cancer treatments such as irradiation or chemotherapy. The problem is that a bone marrow transplant might not succeed because the transplanted stem cells don't live long enough or because they proliferate too well, leading to leukemia.

2 Mar 2011

European Commission approves BMY's BARACLUDE(r) to treat CHB in adult patients with liver disease

Bristol-Myers Squibb announced today that BARACLUDE(R) has been approved by the European Commission on February 28th 2011 to treat chronic hepatitis B in adult patients with evidence of decompensated liver disease.

1 Mar 2011

New therapeutic strategy improves superior renal function after kidney transplantation

Researchers at Charité - Universitätsmedizin Berlin, together with 16 other transplant centers in Germany and Switzerland successfully tested a new therapeutic strategy that allows for superior renal function after kidney transplantation. The results were published online in the journal "The Lancet".

1 Mar 2011

Transplant News and Research

Lab made urinary tube going strong after six years of transplant

Researchers develop new method for DNA sequencing analysis

First western U.S. hand transplant surgery performed at UCLA Medical Center

hUCBs and MenSCs transplant may offer future therapeutic benefit for AD, stroke, ALS

State roundup: Mass. effort to manage care for chronically ill; promoting organ donations

First implantable heart transplant using new LVAD performed at University of Utah Hospital

Pfizer's ORAL Sync Phase 3 study of tofacitinib in moderate-to-severe RA meets primary endpoints

Viewpoints: Gambling on entitlement cuts; 'culture war' over family planning; insurance premium 'gouge' in Calif.

ThermoGenesis prices offering of 2,250,000 shares of common stock

Sangamo's preclinical ZFN-gene modification studies for HIV/AIDS treatment presented at CROI

Low physical activity increases kidney transplant patients' likelihood of dying early

First artificial bronchus graft in a lung cancer patient successful

Racial and ethnic groups less likely to receive kidney transplants than others

Organ transplant deaths investigated

Vical receives EMA Scientific Advice for Phase 3 trial of TransVax therapeutic CMV vaccine

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

Genetic variants determine severity of HCV-related graft disease and antiviral treatment response

Mathematical model predicts lifespan of stem cells

European Commission approves BMY's BARACLUDE(r) to treat CHB in adult patients with liver disease

New therapeutic strategy improves superior renal function after kidney transplantation

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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