Tumor News and Research

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Lactate's role in driving cancer cachexia uncovered

Study highlights the significant role of lactate in promoting cancer cachexia via activation of the adipose-specific G-protein-coupled receptor 81 (GPR81), suggesting new therapeutic targets for this condition.

20 Mar 2024

Immune cell protein identified as potential target for rare liver cancer treatment

Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein.

20 Mar 2024

Cryoablation could be a new treatment path for breast cancer patients with large tumors

A minimally invasive technique that uses ice to freeze and destroy small, cancerous tumors has now been proven effective for breast cancer patients with large tumors, providing a new treatment path for those who are not candidates for surgery, according to new research to be presented at the Society of Interventional Radiology Annual Scientific Meeting in Salt Lake City.

20 Mar 2024

Tracking circulating tumor DNA could indicate gastroesophageal cancer treatment response

Monitoring levels of DNA shed by tumors and circulating in the bloodstream could help doctors accurately assess how gastroesophageal cancers are responding to treatment, and potentially predict future prognosis, suggests a new study led by researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

19 Mar 2024

Exposure to high heat may increase inflammation and interfere with immune system functions

Short-term exposure to higher heat may increase inflammation and interfere with normal immune system functions in the body, which may, in turn, increase susceptibility to infections and accelerate the progression of cardiovascular disease, according to preliminary research to be presented at the American Heart Association's Epidemiology and Prevention│Lifestyle and Cardiometabolic Scientific Sessions 2024, March 18- 21, in Chicago.

19 Mar 2024

Developing mRNA lipid nanoparticles for treating oral squamous cell carcinoma

A study aiming to develop a Lipid nanoparticles (LNP) platform for treating oral squamous cell carcinoma (OSCC) utilizing p53 mRNA was presented at the 102nd General Session of the IADR, which was held in conjunction with the 53rd Annual Meeting of the American Association for Dental, Oral, and Craniofacial Research and the 48th Annual Meeting of the Canadian Association for Dental Research, on March 13-16, 2024, in New Orleans, LA, USA.

19 Mar 2024

Advancing computational pathology with UNI and CONCH foundation models

Foundation models, advanced artificial intelligence systems trained on large-scale datasets, hold the potential to provide unprecedented advancements for the medical field.

19 Mar 2024

Genetic key to milder COVID: Certain genes slash severity and death risk in older men

Study found that certain genetic variants in the IL1RN gene significantly reduce COVID-19-related inflammation and mortality in patients, with notable improvements observed in older men carrying specific single-nucleotide variants.

19 Mar 2024

Artichoke's health secret, traditional remedy to modern marvel

Study highlights the artichoke's nutritional benefits and its potential to improve cardiovascular health, exhibit neuroprotective effects, and offer antimicrobial properties, emphasizing its value beyond dietary use.

18 Mar 2024

Study uncovers how APOBEC enzymes drive cancer mutations

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

18 Mar 2024

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity.

18 Mar 2024

New insights into upper tract urothelial carcinoma evolution and treatment

Researchers at Weill Cornell Medicine have performed the most comprehensive analysis to date of cancer of the ureters or the urine-collection cavities in the kidney, known as upper tract urothelial carcinoma (UTUC).

18 Mar 2024

Synthetic mucins shed light on cancer biology and tumor formation

During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health.

18 Mar 2024

Clinical trial aims to provide a surgical solution for patients with 'inoperable' pancreatic tumors

A clinical trial from Keck Medicine of USC aims to provide a surgical solution for patients with a form of advanced pancreatic cancer previously considered inoperable.

18 Mar 2024

Scientists aim to understand why T cells do not sustain energy in tumors

T cells are often called "assassins" or "killers" because they can orchestrate and carry out missions to hunt down bacteria, viruses, and cancer cells throughout the body.

15 Mar 2024

BU study reveals key to combating high-risk neuroblastoma

The MYCN oncoprotein (proteins related to the growth of cancer cells) plays a key role in starting, advancing and making it difficult to treat various human cancers.

15 Mar 2024

Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center (DKFZ) and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

15 Mar 2024

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

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Tumor News and Research

Lactate's role in driving cancer cachexia uncovered

Immune cell protein identified as potential target for rare liver cancer treatment

Cryoablation could be a new treatment path for breast cancer patients with large tumors

Tracking circulating tumor DNA could indicate gastroesophageal cancer treatment response

Exposure to high heat may increase inflammation and interfere with immune system functions

Developing mRNA lipid nanoparticles for treating oral squamous cell carcinoma

Advancing computational pathology with UNI and CONCH foundation models

Genetic key to milder COVID: Certain genes slash severity and death risk in older men

Artichoke's health secret, traditional remedy to modern marvel

Study uncovers how APOBEC enzymes drive cancer mutations

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

New insights into upper tract urothelial carcinoma evolution and treatment

Synthetic mucins shed light on cancer biology and tumor formation

Clinical trial aims to provide a surgical solution for patients with 'inoperable' pancreatic tumors

Scientists aim to understand why T cells do not sustain energy in tumors

BU study reveals key to combating high-risk neuroblastoma

Machine learning classifier reduces the time to identify personalized tumor reactive T cell receptors

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Exploring olive oil compounds oleuropein and hydroxytyrosol as potential treatments for neuroblastoma

Innovative CAR T cell therapy targets two proteins to combat aggressive brain tumor growth

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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