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Researchers identify switches that can turn on or off genes associated with colorectal cancer

Two researchers at the Geisel School of Medicine at Dartmouth have helped to identify switches that can turn on or off genes associated with colorectal cancer. The finding offers clues about the development of colorectal cancer and could-potentially-provide targets for new therapies.

4 May 2012

Hypoxia may be a primary cause of uncontrollable tumor growth in cancers

Low oxygen levels in cells may be a primary cause of uncontrollable tumor growth in some cancers, according to a new University of Georgia study. The authors' findings run counter to widely accepted beliefs that genetic mutations are responsible for cancer growth.

4 May 2012

CAPE arrests growth of prostate cancer cells and tumors in mice

An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.

4 May 2012

Reuters examines cancer in Africa

Reuters examines cancer in Africa, writing, "Most of Africa's around 2,000 languages have no word for cancer. The common perception in both developing and developed countries is that it's a disease of the wealthy world, where high-fat, processed-food diets, alcohol, smoking and sedentary lifestyles fuel tumor growth."

3 May 2012

New clues about why immune system fails to kill tumors in mice

A pioneering approach to imaging breast cancer in mice has revealed new clues about why the human immune system often fails to attack tumors and keep cancer in check. This observation, by scientists at the University of California, San Francisco (UCSF), may help to reveal new approaches to cancer immunotherapy.

3 May 2012

Ben & Catherine Ivy Foundation to fund $45,000 pilot internship program at TGen

The Arizona-based Ben & Catherine Ivy Foundation will fund a $45,000 pilot internship program this summer and fall at the Translational Genomics Research Foundation (TGen).

3 May 2012

Math models can be useful tools for study of cancer progression

Using mathematical models, researchers in the Integrated Mathematical Oncology (IMO) program at Moffitt Cancer Center are focusing their research on the interaction between the tumor and its microenvironment and the "selective forces" in that microenvironment that play a role in the growth and evolution of cancer.

3 May 2012

Misleading information about breast brachytherapy

One of the leading experts on radiation therapy for breast cancer says a new study in JAMA -- about breast cancer treatment - has misleading information and may unnecessarily deter women from getting breast brachytherapy, a safe and effective treatment.

2 May 2012

Expression of tyrosine kinases may limit effectiveness of agents against sarcomas

To better understand the signaling pathways active in sarcomas, researchers at Moffitt Cancer Center used state-of-the-art mass spectrometry-based proteomics to characterize a family of protein enzymes that act as "on" or "off" switches important in the biology of cancer. The tyrosine kinases they identified, the researchers said, could act as "drivers" for the growth and survival of sarcomas.

2 May 2012

Lenalidomide and SNS01-T combination effective against multiple myeloma

Senesco Technologies, Inc. announced today that a high level of tumor eradication in a mouse model of human multiple myeloma was achieved with a combination of SNS01-T and lenalidomide.

2 May 2012

APBI, WBI equally effective in preventing local breast cancer recurrence

Accelerated Partial Breast Irradiation (APBI) also known as brachytherapy, is equally effective--if not more effective-- in preventing local breast cancer recurrence than Whole Breast Irradiation (WBI), according to a study to be presented this week at the American Society of Breast Surgeons (ASBrS) Annual Meeting.

2 May 2012

Topline, interim results from Celldex Phase 2b EMERGE study of CDX-011 for advanced breast cancer

Celldex Therapeutics, Inc. today announced that interim, topline results of the Phase 2b EMERGE study of CDX-011 in patients with advanced breast cancer will be presented in a webcast on May 23, 2012. Linda Vahdat, MD, Professor of Medicine, Chief of Solid Tumor Service and Director of the Breast Cancer Research Program at Weill Cornell Medical College and the lead investigator of the EMERGE study, will join Celldex on the webcast to discuss data from the study.

2 May 2012

Accelerated partial breast irradiation therapy increases risk for subsequent mastectomy

Accelerated partial breast irradiation (APBI) brachytherapy, the localized form of radiation therapy growing increasingly popular as a treatment choice for women with early-stage breast cancer, is associated with higher rate of later mastectomy, increased radiation-related toxicities and post-operative complications, compared to traditional whole breast irradiation (WBI), according to researchers from The University of Texas MD Anderson Cancer Center.

2 May 2012

NKCC1 protein may hold clues to how glioblastoma moves and invades

Johns Hopkins researchers have discovered that a protein that transports sodium, potassium and chloride may hold clues to how glioblastoma, the most common and deadliest type of brain cancer, moves and invades nearby healthy brain tissue.

2 May 2012

Cancer genomes in a common database and computation of disease drivers

The emerging field of "personalized" or "precision" medicine holds great promise in the fight against cancer. If scientists can identify the genetic changes that drive each patient's cancer cells, they can use that information to develop targeted treatments. But achieving this goal will require massive amounts of genomic and clinical data and a sophisticated infrastructure to manage and analyze the data.

2 May 2012

Novel technique helps surgeons to remove 'inoperable' abdominal tumors

Abdominal tumors involving both roots of the celiac and superior mesenteric artery (SMA) are deemed unresectable by conventional surgical methods, as removal would cause necrosis of the organs that are supplied by those blood vessels.

2 May 2012

Seed localization improves satisfaction of breast cancer patients

A cutting-edge procedure called seed localization is improving patient satisfaction at The Dubin Breast Center of the Tisch Cancer Institute at The Mount Sinai Medical Center. In patients undergoing lumpectomy for cancers that are small and cannot be felt in the breast, a tiny radioactive seed is guided into the breast and implanted at the site of the tumor.

2 May 2012

High-dose glucocorticoids double risk of bacterial infections in children with JIA

Children with juvenile idiopathic arthritis have higher rates of bacterial infection requiring hospitalization, and use of high-dose steroids significantly increases that risk, according to research from the University of Alabama at Birmingham.

2 May 2012

Tyrosine kinases could act as drivers for growth and survival of sarcomas

2 May 2012

High-dose steroids increase infection risk in children with juvenile idiopathic arthritis

Children with juvenile idiopathic arthritis (JIA) have higher rates of hospitalized bacterial infection than children without JIA according to an observational study appearing in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

2 May 2012