Ubiquitin News and Research

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Ubiquitin is a small regulatory protein that has been found in almost all cells (''ubiquitously'') with nuclei (eukaryotes). It directs proteins to recycling and other functions.

Arvinas, Merck team up to create new therapeutics using protein degradation technology

Arvinas LLC, a private biotechnology company creating a new class of drugs based on protein degradation, announced a strategic collaboration with Merck, known as MSD outside of the United States and Canada, in which Arvinas' novel PROTAC technology will be used to degrade target proteins, with the goal of creating novel therapeutics.

7 Apr 2015

York U researchers identify how living beings can keep gene expression in check

York University researchers have learned how living beings can keep gene expression in check -- which might partly explain the uncontrolled gene expression found in many cancers.

16 Mar 2015

Vanderbilt researchers find link between the biological clock and Angelman syndrome

Monitoring participants' biological clocks may be the quickest way to determine the effectiveness of experimental drugs currently under development to treat Angelman syndrome: a debilitating genetic disorder that occurs in more than one in every 15,000 live births.

6 Feb 2015

Recipients of The 2015 Protein Society Awards announced

The Protein Society, the premiere international society dedicated to supporting protein research, announces the winners of The 2015 Protein Society Awards. The awards will be conferred at the 29th Annual Symposium of The Protein Society (July 22-25, 2015, Barcelona, Spain).

5 Feb 2015

TUM researchers discover new mechanism for regulating programmed cell death

Programmed cell death is a mechanism that causes defective and potentially harmful cells to destroy themselves. It serves a number of purposes in the body, including the prevention of malignant tumor growth. Now, researchers at Technische Universität München have discovered a previously unknown mechanism for regulating programmed cell death.

18 Dec 2014

FL118 agent shows efficacy as personalized, targeted therapy for certain cancer tumors

A team led by Fengzhi Li, PhD, and Xinjiang Wang, PhD, of Roswell Park Cancer Institute has reported new findings regarding therapeutic targets of the novel anticancer agent FL118. Previous studies from these researchers have showed that FL118 induces cancer cell death, or apoptosis, by inhibiting expression of multiple cell-survival proteins (survivin, Mcl-1, XIAP or cIAP2).

15 Dec 2014

Researchers discover two common genetic variants associated with memory performance

In the largest study of the genetics of memory ever undertaken, an international researcher team including scientists from Boston University School of Medicine, have discovered two common genetic variants that are believed to be associated with memory performance.

25 Nov 2014

Understanding neuron development: an interview with Dr. Brock Grill, The Scripps Research Institute

There’s a big difference between understanding coordination and actually building connectivity. In terms of building connectivity, several molecules have been identified that control this process and a lot has been learned from both genetic and biochemical research in a variety of different systems, particularly studies in the nematode C. elegans, the fruit fly Drosophila and mice.

22 Aug 2014

Using NMR to study protein motion: an interview with Fabien Ferrage, École Normale Supérieure, Paris

Can you give us a brief overview of the work you presented at ENC 2014 (Experimental Nuclear Magnetic Resonance Conference)?

From Bruker BioSpin - NMR, EPR and Imaging 19 Aug 2014

Study shows inactivation of p53 protein promotes cancer progression

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL) and the University of Barcelona have discovered the interaction between HERC2 proteins with another protein called p53 that is inactivated in more than half of human tumors.

22 Jul 2014

UT Southwestern researcher named recipient of ASBMB Merck Award for research on molecular biology

Dr. Zhijian "James" Chen, Professor of Molecular Biology and a Howard Hughes Medical Institute investigator at UT Southwestern Medical Center, has been named the 2015 recipient of the American Society for Biochemistry and Molecular Biology Merck Award, which recognizes outstanding contributions to research in biochemistry and molecular biology.

18 Jul 2014

Research sheds light on key mechanism prevalent in Alzheimer's disease patients

Alzheimer's disease affects approximately 5.2 million people in the United States alone, and it is the nation's sixth leading cause of death.

16 Jul 2014

New study sheds light on role of RPM-1 protein in neuron development

In a new study, scientists from the Florida campus of The Scripps Research Institute have shed new light on these complex processes, showing that a particular protein plays a far more sophisticated role in neuron development than previously thought.

11 Jul 2014

Research uncovers how complex protein pivotal in cancer development is activated

New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated.

10 Jul 2014

Keck Medicine of USC study identifies potential therapeutic target for inflammation

Molecular microbiologists from the Keck School of Medicine of the University of Southern California have discovered that mice lacking a specific component of the immune system are completely resistant to sepsis, a potentially fatal complication of infection.

10 Jul 2014

Scientists find a new strategy for brain cancer treatment

Scientists at the Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre have shown that a member of the protein family known as SUMO (small ubiquitin-like modifier) is a key to why tumour cells multiply uncontrollably, especially in the case of glioblastoma. T

9 Jul 2014

Research reveals key aspect of protein regulation in cells

St. Jude Children's Research Hospital scientists have discovered how an important "on" switch is attached to the machinery that cells rely on to adapt thousands of proteins to meet changing conditions.

20 Jun 2014

Researchers figure out way to disable a part of SARS virus

A Purdue University-led research team has figured out how to disable a part of the SARS virus responsible for hiding it from the immune system; a critical step in developing a vaccine against the deadly disease.

4 Jun 2014

New research shows how misfolded proteins are precisely selected for degradation

It's almost axiomatic that misfolded proteins compromise how cells normally function and cause debilitating human disease, but how these proteins are detected and degraded within the body is not well understood.

30 May 2014

Study of rare childhood neurodegenerative diseases identifies new source of DNA damage

St. Jude Children's Research Hospital scientists studying two rare, inherited childhood neurodegenerative disorders have identified a new, possibly common source of DNA damage that may play a role in other neurodegenerative diseases, cancer and aging.

12 May 2014