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Investigational compound inhibits cancer-specific mutations in mice

Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell.

30 May 2017

Gene editing technology can introduce hundreds of unintended mutations, study shows

As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.

29 May 2017

Research suggests potential of stem cells to improve tendon healing

New research published online in The FASEB Journal suggests that tendon stem (TSCs) may be able to significantly improve tendon healing by regulating inflammation, which contributes to scar-like tendon healing and chronic matrix degradation.

23 May 2017

Pulmonary thrombosis-on-a-chip enables unprecedented study of blood responses to organ-level injury

The average human pair of lungs is permeated by a network of about 164 feet of blood vessels (roughly the width of a football field), including microscopic blood capillaries, which facilitate the diffusion of oxygen into the bloodstream in exchange for carbon dioxide.

23 May 2017

Researchers demonstrate multicolor 3D imaging of live mouse using compact Compton camera

Researchers invented a Compton camera of 580g which visualizes gamma rays of arbitrary energies, and succeeded in achieving a high-resolution, multicolor 3D molecular image of a live mouse administered with three different radioactive tracers in just 2 hours.

23 May 2017

Electrical stimulation of the brain may help preserve visual neurons from cell death after injury

Electrical stimulation of the brain by applying current to the eye may help retinal nerve cells to survive injury. While these neurons may not be restored to full function, they are prevented from dying. But to achieve survival, their interconnections, the dendritic tree, needs to disconnect rapidly for the protective action to unfold.

18 May 2017

New research could be first step toward drug to treat Zika infections

New research led by Alexey Terskikh, Ph.D., associate professor at Sanford Burnham Prebys Medical Discovery Institute (SBP), and Alex Strongin, Ph.D., professor at SBP, could be a first step toward a drug to treat Zika infections. Publishing in Antiviral Research, the scientific team discovered a compound that prevents the virus from spreading.

16 May 2017

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti, a technology research institute of CEA Tech, today announced a European Union project to develop a nanotherapy targeting the molecules involved in inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis.

12 May 2017

Researchers discover dual-functional compound that shows potential to combat type 1, type 2 diabetes

According to research published online in The FASEB Journal, scientists have discovered a dual peptide called "PGLP-1" that promotes insulin secretion and inhibits gluconeogenesis.

11 May 2017

Breast cancer drug offers protection against obesity-related metabolic disorders

Tamoxifen, a selective estrogen receptor modulator, is the gold standard for endocrine treatment of estrogen-receptor positive breast cancer.

11 May 2017

Demyelination may not be good indicator of MS progression, study finds

A study by researchers from Queen Mary University of London establishes for the first time the extent of neuronal loss in the brain of a person with MS over their life and finds that demyelination may not be as good an indicator of disease progression as previously thought.

10 May 2017

Study findings suggest how progranulin deficiency causes frontotemporal dementia

In a recent study in Human Molecular Genetics, researchers from VIB and KU Leuven led by prof. Philip Van Damme, reveal a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin D. The results were obtained in collaboration with Prof. Paul Saftig from the University of Kiel.

8 May 2017

Texas A&M researchers aim to develop one drug that treats pain, memory and nicotine addiction

Although pain, memory and nicotine addiction may not seem to be related, they actually share a common player: the nicotinic acetylcholine receptors.

5 May 2017

New technique improves accuracy, reduces costs of real-time assessment of kidney function

A new technique developed by researchers at Lawrence Livermore National Lab promises to improve accuracy and lower costs of real-time assessment of kidney function, reports an article published this week by SPIE, the international society for optics and photonics, in the Journal of Biomedical Optics.

5 May 2017

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia.

4 May 2017

Lethal DNA re-replication may be used to attack cancer cells

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, composition and/or number of chromosomes), and this process gives rise to aberrant cells as those detected in many carcinomas.

4 May 2017

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

10x Genomics, a company focused on enabling the mastery of biology by accelerating genomic discovery, today announced publication of an article in the journal Nature of a collaborative research study with researchers at the Stanford University School of Medicine.

From 10x Genomics, Inc. 4 May 2017

New research on nanodiamond-enhanced MRI

Research by a collaboration of scientists in Australia and the United States demonstrates that using nanodiamonds somewhat like ‘tiny machines’ inside living patients has taken a quantum leap closer to reality.

3 May 2017

Molecular drug imaging likely to benefit children with brain tumors

Brain cancers are difficult to treat, and it can be hard to predict whether a therapy will be effective. When the patient is a child, it's even more important to predict the potential effectiveness of a drug before beginning treatment.

3 May 2017

SyMRI approach provides myelin maps in scan times of only 5 minutes

It has been a long-standing dream in MRI to move from visualizing tissue contrast differences to directly imaging patient tissue properties. Recent developments within quantitative MRI have provided substantial steps forward in measuring the basic physical properties such as T1 and T2 relaxation times or proton density.

2 May 2017

in vivo News and Research

Investigational compound inhibits cancer-specific mutations in mice

Gene editing technology can introduce hundreds of unintended mutations, study shows

Research suggests potential of stem cells to improve tendon healing

Pulmonary thrombosis-on-a-chip enables unprecedented study of blood responses to organ-level injury

Researchers demonstrate multicolor 3D imaging of live mouse using compact Compton camera

Electrical stimulation of the brain may help preserve visual neurons from cell death after injury

New research could be first step toward drug to treat Zika infections

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Researchers discover dual-functional compound that shows potential to combat type 1, type 2 diabetes

Breast cancer drug offers protection against obesity-related metabolic disorders

Demyelination may not be good indicator of MS progression, study finds

Study findings suggest how progranulin deficiency causes frontotemporal dementia

Texas A&M researchers aim to develop one drug that treats pain, memory and nicotine addiction

New technique improves accuracy, reduces costs of real-time assessment of kidney function

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Lethal DNA re-replication may be used to attack cancer cells

New study uses 10x Genomics’ Single Cell 3’ Solution to unravel stem cell self-renewal mechanism

New research on nanodiamond-enhanced MRI

Molecular drug imaging likely to benefit children with brain tumors

SyMRI approach provides myelin maps in scan times of only 5 minutes

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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